
Ashvin Vijayakumar, MD, MS
Founder & Principal Physician-Investigator, Fishtown Medicine Clinical Evidence & Point-of-Care Translation Lab (Philadelphia, PA)
Evidence Corpus Metrics
All / 2025-2026- Peer-Cited Clinical Monographs
- 587
- Primary PubMed Citations
- 332
- Unique Indexed PMIDs
- 219
- Open-Access Clinical Guides
- 687
- Highwire Press Meta Indexing
- citation_* active
Academic Training, Fellowship & Clinical Leadership
| Appointment / Degree | Institution | Focus & Distinctions |
|---|---|---|
| Principal Physician-Investigator (2024 - Present) | Fishtown Medicine (Philadelphia, PA) | Preventive internal medicine, point-of-care evidence translation, biomarker target governance, and open-access clinical monographs. |
| Prior Clinical Executive Leadership | Oak Street Health & CVS Healthspire | Board-Elected Medical Director & Partner (Oak Street Health); Medical Director (CVS Healthspire). Multi-site value-based primary care outcomes and clinical protocol governance. |
| MS, Healthcare Delivery Leadership (2017 - 2019) | Icahn School of Medicine at Mount Sinai (New York, NY) | Full Merit Scholarship; Fellowship in Value-Based Care Delivery Leadership and clinical systems implementation. |
| Residency, Internal Medicine (2014 - 2017) | AtlantiCare Regional Medical Center | Inpatient ICU, emergency, and ambulatory internal medicine training; ABIM Board Certified in Internal Medicine. |
| Doctor of Medicine, MD (2014) | American University of Antigua College of Medicine | Summa Cum Laude. |
| BA, Biology / Minor in Business (2005 - 2009) | New Jersey Institute of Technology | Cum Laude, National Merit Scholar, Full Academic Scholarship. |
Point-of-Care Evidence Translation & Clinical Research Program
Our research and clinical publishing program investigates how frontline internal medicine practices close the translation gap between peer-reviewed randomized trials and point-of-care patient decisions.
Closing the Evidence-to-Point-of-Care Translation Gap
Primary clinical trial findings take an average of 17 years to reach routine outpatient practice. Our clinical evidence program synthesizes randomized controlled trials, imaging registries (SCOT-HEART, SCAPIS, Miami Heart), and society guidelines into deterministic primary care thresholds for apolipoprotein B (ApoB), lipoprotein(a), fasting insulin, DEXA body composition (ALMI and visceral adipose tissue), non-anemic iron deficiency, and perimenopause endocrinology.
- • Deterministic biomarker target registry (src/data/biomarker-targets.ts) separating late-stage disease reference cutoffs from trial-supported preventive targets.
- • Evidence-graded cancer and cardiovascular screening appropriateness criteria (src/data/cancer-risk.ts) preventing low-value commercial scans and false-positive cascades.
- • Point-of-care literature appraisal integrating OpenEvidence, primary PubMed trial verification, UpToDate, and specialty society guidelines during active clinical care.
Dual-Register Health Information Science & Comprehension Engineering
Standard medical writing forces a trade-off between clinician-grade statistical precision and patient-grade readability. Our monographs apply cognitive and decision science so each publication serves both reviewing clinicians and patients without losing a single trial sample size, hazard ratio, or PubMed identifier.
- • Fuzzy-Trace Dual-Register Encoding (Reyna, 2008): Every monograph pairs verbatim quantitative trial statistics (N, hazard ratios, absolute risk reductions, and direct PMIDs) with bottom-line clinical gist.
- • Evaluative Categorical Boundaries (Zikmund-Fisher, 2014): Lab and imaging tables map raw continuous numbers across Standard Lab Reference, Preventive Target, and Action Threshold columns.
- • Implementation Intentions (Gollwitzer, 1999) and Cognitive Load Control (Sweller, 1988): Clinical guidance closes with explicit If -> Then action triggers while holding clinical Flesch-Kincaid grade level at or below 8.8.
Fail-Closed Clinical Decision Support & Safety Architecture
Medical AI and clinical decision support tools require deterministic guardrails at high-consequence boundaries. We design and evaluate software-enforced clinical safety invariants across prescribing rules, diagnostic ordering, urgent symptom triage, and after-visit documentation.
- • Single-source-of-truth clinical registries governing prescribing boundaries, laboratory reference targets, and imaging appropriateness.
- • Adversarial clinical verification ("Skeptic Pass") auditing high-blast-radius clinical thresholds and eligibility rules against primary literature.
- • Highwire Press academic metadata (citation_title, citation_author, citation_publication_date, citation_fulltext_html_url) emitted across all open-access clinical monographs.
Indexed Clinical Monographs & Evidence Syntheses (587)
Open-access clinical monographs authored by A. Vijayakumar, MD, MS with direct PubMed (PMID) primary trial citations and Highwire Press metadata.
| Title / Author / Clinical Monograph Scope | Indexed PubMed (PMID) Citations | Year |
|---|---|---|
| ME/CFS and Post-Exertional Malaise: Can You Raise Your Energy Ceiling, or Only Pace Around It? A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Why fixed "add 1 minute" exercise plans backfire in ME/CFS, how heart-rate pacing works, and the treatable contributors that move your baseline up. Primary anchor: National Institute for Health and Care Excellence (NICE). "Myalgic encephalomyelitis (or encephalopathy)/chronic fatigue syndrome: diagnosis and management." NICE Guideline NG206. October 2021. NICE | 28 primary references (22 PubMed PMIDs) | 2026 |
| Creatine: The Brain, Bone & Muscle Molecule A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Why 3 to 5 grams of creatine monohydrate protects aging muscle and stressed brains, and why a small rise in blood creatinine is a harmless false alarm confirmed by Cystatin C. Primary anchor: Kreider RB, Gonzalez DE, Hines K, Gil A, Bonilla DA. Safety of creatine supplementation: analysis of the prevalence of reported side effects in clinical trials and adverse event reports. J Int Soc Sports Nutr. 2025;22(1):2488937. PubMed | 27 primary references (21 PubMed PMIDs) | 2026 |
| Getting Through an MRI When the Scanner Makes You Panic A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Diagnostic Imaging & Biomarker Triage) What to arrange before an MRI if the tube makes you panic, what helps on the table, and what to do if you already had to stop a scan partway through. Primary anchor: Munn Z, Moola S, Lisy K, Riitano D, Murphy F. "Claustrophobia in magnetic resonance imaging: a systematic review and meta-analysis." Radiography. 2015;21(2):e59-e63. Radiography | 20 primary references (13 PubMed PMIDs) | 2026 |
| Your Ear Is Blocked A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) Why a cotton swab packs wax against the eardrum, how softening drops are meant to be used, when rinsing an ear is unsafe, and when a blocked ear is not wax. Primary anchor: Schwartz SR, Magit AE, Rosenfeld RM, et al. "Clinical Practice Guideline (Update): Earwax (Cerumen Impaction)." Otolaryngology-Head and Neck Surgery. 2017;156(1_suppl):S1-S29. Journal | 14 primary references (8 PubMed PMIDs) | 2026 |
| Painful Periods That Everyone Told You Were Normal A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) Severe period pain has 2 very different causes. How to tell them apart, how to time an anti-inflammatory so it works, and what to track before the visit. Primary anchor: Marjoribanks J, Ayeleke RO, Farquhar C, Proctor M. Nonsteroidal anti-inflammatory drugs for dysmenorrhoea. Cochrane Database of Systematic Reviews. 2015;(7):CD001751. https://pubmed.ncbi.nlm.nih.gov/26224322/ | 12 primary references (8 PubMed PMIDs) | 2026 |
| When the Adhesive Is the Problem A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Diagnostic Imaging & Biomarker Triage) Itching under a heart monitor patch, glucose sensor, or watch band. How to prepare the skin, calm a reaction, and still get the data that answers your question. Primary anchor: Turakhia MP, Hoang DD, Zimetbaum P, et al. "Diagnostic Utility of a Novel Leadless Arrhythmia Monitoring Device." American Journal of Cardiology. 2013;112(4):520-524. PubMed | 12 primary references (8 PubMed PMIDs) | 2026 |
| Heavier Periods After Kids, Early Perimenopause, and Why Menstrual Discs Help A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Endocrinology & Reproductive Health) Why periods get heavier after kids and in early perimenopause, how single-use menstrual discs help on heavy days, and which cycle-day 2 to 5 labs to run. Primary anchor: DeLoughery E, Colwill AC, Edelman A, Samuelson Bannow B. Red blood cell capacity of modern menstrual products: considerations for assessing heavy menstrual bleeding. BMJ Sex Reprod Health. 2024;50(1):21-26. PMID: 37550075 | 8 primary references (8 PubMed PMIDs) | 2026 |
| Swollen Feet and Ankles A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) Pitting or not, 1 leg or both: the 2 questions that sort swollen feet and ankles, plus the medication causes and the swelling that needs same-day care. Primary anchor: Trayes KP, Studdiford JS, Pickle S, Tully AS. "Edema: Diagnosis and Management." American Family Physician. 2013;88(2):102-110. PubMed | 13 primary references (7 PubMed PMIDs) | 2026 |
| Adenomyosis: When Periods Are Heavy and Deeply Painful A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Adenomyosis puts endometrial-type tissue inside the muscle wall of the uterus. What ultrasound can and cannot show, how it differs from endometriosis and fibroids, and what helps. Primary anchor: Harmsen MJ, Van den Bosch T, de Leeuw RA, et al. Consensus on revised definitions of Morphological Uterus Sonographic Assessment (MUSA) features of adenomyosis: results of modified Delphi procedure. Ultrasound in Obstetrics & Gynecology. 2022;60(1):118-131. https://obgyn.onlinelibrary.wiley.com/doi/10.1002/uog.24786 | 12 primary references (7 PubMed PMIDs) | 2026 |
| Can You Take Too Much of a B Vitamin? A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Vitamin B6 causes nerve damage at doses many supplements carry. Folic acid can hide a B12 deficiency. The upper limits, and which B vitamins are safe. Primary anchor: National Institutes of Health, Office of Dietary Supplements. "Vitamin B6: Fact Sheet for Health Professionals." https://ods.od.nih.gov/factsheets/VitaminB6-HealthProfessional/ | 16 primary references (6 PubMed PMIDs) | 2026 |
| Zinc and Copper: Getting the Balance Right A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Long-term zinc can pull copper down before symptoms appear. How much zinc is too much, what the blood tests show, and how to take zinc safely. Primary anchor: Institute of Medicine, Panel on Micronutrients. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. National Academies Press, 2001. Zinc chapter: https://www.ncbi.nlm.nih.gov/books/NBK222317/ ; copper chapter: https://www.ncbi.nlm.nih.gov/books/NBK222312/ | 16 primary references (6 PubMed PMIDs) | 2026 |
| Is It Lifelong ADHD, Inattention, or Early Dementia? A Clinical Guide for Adult Children Worried About a Parent A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Geroscience & Healthspan Medicine) How to tell whether an aging parent's forgetfulness and disorganization stem from lifelong ADHD, a reversible medication or sleep issue, or early Mild Cognitive Impairment (MCI), and what workup to request. | 6 primary references (6 PubMed PMIDs) | 2026 |
| The "Customized" Supplement Trap: Why Online Lab-to-Vitamin Programs Fail A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Paying $200/month for "custom" supplements from an online blood panel? Dr. Ash explains why algorithmic pill packs fail and what moves your labs in 90 days. Primary anchor: O'Connor EA, Evans CV, Ivlev I, et al. Vitamin and Mineral Supplements for the Primary Prevention of Cardiovascular Disease and Cancer: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force. JAMA. 2022;327(23):2334-2347. | 6 primary references (6 PubMed PMIDs) | 2026 |
| When a Blood Pressure Medication Stops Working A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Therapeutics & Pharmacology) Why a losartan-to-telmisartan switch is often the next move, where a thiazide-like diuretic fits, and when to look for a cause behind the number. Primary anchor: "Clinical pharmacokinetics of losartan." Clinical Pharmacokinetics. 2005;44(8). PubMed | 17 primary references (5 PubMed PMIDs) | 2026 |
| Toenail Fungus: Why the Cream Keeps Failing A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) A cream cannot cross the nail plate to reach fungus in the nail bed. What onychomycosis takes to clear, and why confirming the diagnosis comes first. Primary anchor: "Onychomycosis: Rapid Evidence Review." American Family Physician. 2021;104(4):359-367. AAFP | 16 primary references (5 PubMed PMIDs) | 2026 |
| Yeast Infection, or Something That Looks Like One A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) How to tell a yeast infection from bacterial vaginosis, trichomoniasis, and a bladder infection, and how yeast is treated. Primary anchor: Centers for Disease Control and Prevention. "Vulvovaginal Candidiasis." Sexually Transmitted Infections Treatment Guidelines, 2021. CDC | 8 primary references (5 PubMed PMIDs) | 2026 |
| The 4-Gate Supplement Strategy: Need, Safety, Human Dose, and Exit Date A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Why a shoebox of 15 supplements fails your biochemistry, and how Fishtown Medicine filters every capsule through four clinical gates: measured lab need, USP or NSF batch safety, human trial dosing, and a 90-day exit strategy. Primary anchor: Geller AI, Shehab N, Weidle NJ, et al. "Emergency Department Visits for Adverse Events Related to Dietary Supplements." New England Journal of Medicine. 2015;373(16):1531-1540. PubMed | 5 primary references (5 PubMed PMIDs) | 2026 |
| Your PSA Came Back High A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Diagnostic Imaging & Biomarker Triage) The ordinary things that raise a PSA, how to repeat the test so the number means something, and the point at which a urologist belongs in the picture. Primary anchor: Thompson IM, Pauler DK, Goodman PJ, et al. "Prevalence of Prostate Cancer among Men with a Prostate-Specific Antigen Level ≤4.0 ng per Milliliter." New England Journal of Medicine. 2004;350(22):2239-2246. PubMed | 5 primary references (5 PubMed PMIDs) | 2026 |
| Endometriosis: What a Normal Scan Cannot Tell You A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) A normal pelvic ultrasound or MRI does not rule out endometriosis. What imaging can and cannot answer, the conditions that mimic it, and what to do now. Primary anchor: American College of Obstetricians and Gynecologists. "Diagnosis of Endometriosis." ACOG Clinical Practice Guideline. Obstetrics & Gynecology, published online February 19, 2026. | 19 primary references (4 PubMed PMIDs) | 2026 |
| Pelvic Venous Disease: When Pelvic Pain Gets Worse by Evening A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) Pelvic pain that aches, drags, and builds through the day may be venous. Why a scan done lying down misses it, and what to ask for instead. Primary anchor: Meissner MH, Khilnani NM, Labropoulos N, et al. "The Symptoms-Varices-Pathophysiology classification of pelvic venous disorders: A report of the American Vein & Lymphatic Society International Working Group on Pelvic Venous Disorders." Journal of Vascular Surgery: Venous and Lymphatic Disorders. 2021;9(3):568-584. JVS-VL00071-8/fulltext) | 17 primary references (4 PubMed PMIDs) | 2026 |
| After the ER: The Follow-Up Visit You Were Told to Get A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Internal Medicine & Prevention) Discharged from a Philadelphia ER and told to follow up in a few days? What that visit should cover, what to bring, and the symptoms that mean go back. Primary anchor: Engel KG, Heisler M, Smith DM, Robinson CH, Forman JH, Ubel PA. "Patient Comprehension of Emergency Department Care and Instructions: Are Patients Aware of When They Do Not Understand?" Annals of Emergency Medicine. 2009;53(4):454-461.e15. doi:10.1016/j.annemergmed.2008.05.016. Structured interviews of 140 adults after ED discharge across 2 health systems; 78% had deficient comprehension in at least 1 of 4 domains, 51% in 2 or more, only 13% understood all 4, and patients perceived a deficit only about 20% of the time. | 12 primary references (4 PubMed PMIDs) | 2026 |
| Hypermobility and hEDS Care in Philadelphia A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Internal Medicine & Prevention) How joint hypermobility and hEDS are diagnosed and managed in Philadelphia by a physician who treats the POTS and MCAS picture together. Primary anchor: Malfait F, Francomano C, Byers P, et al. The 2017 International Classification of the Ehlers-Danlos Syndromes. Am J Med Genet C Semin Med Genet. 2017;175(1):8-26. | 6 primary references (4 PubMed PMIDs) | 2026 |
| How We Choose Supplements A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) How Fishtown Medicine picks supplements: do you need it, is it safe, is the dose effective, then cost, from vetted sources, with every discount passed through and no commission taken. Primary anchor: Tucker J, Fischer T, Upjohn L, Mazzera D, Kumar M. "Unapproved Pharmaceutical Ingredients Included in Dietary Supplements Associated With US Food and Drug Administration Warnings." JAMA Network Open. 2018;1(6):e183337. PubMed | 5 primary references (4 PubMed PMIDs) | 2026 |
| Told You Do Not Have Asthma, But You Still Cough A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) Why a normal breathing test does not rule out asthma, what the mucusy cough is telling us, and how inhaler technique decides whether treatment works. Primary anchor: Global Initiative for Asthma. "Global Strategy for Asthma Management and Prevention." 2024 Update. GINA | 5 primary references (4 PubMed PMIDs) | 2026 |
| When You Need an X-Ray, Body Part by Body Part A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Diagnostic Imaging & Biomarker Triage) What an X-ray shows and misses for each body part, which views matter, when waiting beats scanning, and how much radiation is involved. Primary anchor: Mettler FA Jr, Huda W, Yoshizumi TT, Mahesh M. "Effective doses in radiology and diagnostic nuclear medicine: a catalog." Radiology. 2008;248(1):254-263. PubMed | 5 primary references (4 PubMed PMIDs) | 2026 |
| Your Heart Skips a Beat A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) Why a skipped beat feels like a pause and then a thump, how a 6-lead personal EKG compares to a smartwatch or patch monitor, and the drivers worth fixing. Primary anchor: Ng GA. "Treating patients with ventricular ectopic beats." Heart. 2006;92(11):1707-1712. PubMed | 5 primary references (4 PubMed PMIDs) | 2026 |
| Metoprolol: Tartrate vs Succinate A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Therapeutics & Pharmacology) Why the short-acting form is right for finding your dose and the long-acting one is right for staying on it, plus the pill-in-the-pocket approach. Primary anchor: MERIT-HF Study Group. "Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF)." The Lancet. 1999;353(9169):2001-2007. PubMed | 4 primary references (4 PubMed PMIDs) | 2026 |
| What a WatchPAT Home Sleep Test Costs, and How to Run One A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Diagnostic Imaging & Biomarker Triage) What each version of a home sleep apnea test costs, how to run one yourself, whether a DOT examiner will accept it, and when the result is good enough to act on. Primary anchor: Kapur VK, Auckley DH, Chowdhuri S, et al. "Clinical Practice Guideline for Diagnostic Testing for Adult Obstructive Sleep Apnea: An American Academy of Sleep Medicine Clinical Practice Guideline." Journal of Clinical Sleep Medicine. 2017;13(3):479-504. PubMed | 4 primary references (4 PubMed PMIDs) | 2026 |
| Why Most Supplements Don't Work (And Why You Still Feel Better) A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Internal Medicine & Prevention) Why 50% to 59% of the boost people feel from commercial supplements comes from the brain's expectation loop, why that effect fades by Month 6, and how to separate true biochemical deficiency correction from mislabeled bottles. Primary anchor: Crawford C, Avula B, Lindsey AT, et al. "Analysis of Select Dietary Supplement Products Marketed to Support or Boost the Immune System." JAMA Network Open. 2022;5(8):e2226040. PubMed | 4 primary references (4 PubMed PMIDs) | 2026 |
| Microcytic Anemia: What a Low MCV Means A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Diagnostic Imaging & Biomarker Triage) A low MCV means small red blood cells. Why that is not automatically iron deficiency, how thalassemia trait is ruled out, and when colonoscopy stands. Primary anchor: Van Vranken M. "Evaluation of microcytosis." American Family Physician. 2010;82(9):1117-1122. PMID 21121557. https://www.aafp.org/pubs/afp/issues/2010/1101/p1117.html | 12 primary references (3 PubMed PMIDs) | 2026 |
| Is It Rhabdo, or Just Very Sore? A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) How to tell ordinary post-workout soreness from rhabdomyolysis, when a CK blood test is worth drawing, and what makes a case dangerous to the kidneys. Primary anchor: Scalco RS, Snoeck M, Quinlivan R, et al. Exertional rhabdomyolysis: physiological response or manifestation of an underlying myopathy? BMJ Open Sport & Exercise Medicine. 2016;2(1):e000151. | 11 primary references (3 PubMed PMIDs) | 2026 |
| Joint Aches and Frozen Shoulder: It Is Probably Perimenopause A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) 70% of women have musculoskeletal symptoms in the menopause transition. 25% are disabled by them. Frozen shoulder is often a hormonal signal rather than an orthopedic mystery. Primary anchor: Wright VJ, Schwartzman JD, Itinoche R, Wittstein J. (2024). "The musculoskeletal syndrome of menopause." Climacteric, 27(5), 466-472. PMID: 39077777. | 5 primary references (3 PubMed PMIDs) | 2026 |
| Why We Choose an MRI, and When We Do Not A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Diagnostic Imaging & Biomarker Triage) What MRI sees that CT and X-ray cannot, when contrast is needed, how implants and claustrophobia are handled, and why timing matters more than access. Primary anchor: Brinjikji W, Luetmer PH, Comstock B, et al. "Systematic literature review of imaging features of spinal degeneration in asymptomatic populations." AJNR American Journal of Neuroradiology. 2015;36(4):811-816. PubMed | 3 primary references (3 PubMed PMIDs) | 2026 |
| What Endurance Athletes Do That the Rest of Us Skip A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Exercise Physiology & Cardiorespiratory Fitness) The return-from-layoff math, heat acclimatization, hydration, and the NSAID rule that sports medicine staff manage for professionals and amateurs handle on their own. Primary anchor: Caterisano A, Decker D, Snyder B, et al. CSCCa and NSCA joint consensus guidelines for transition periods: safe return to training following inactivity. Strength and Conditioning Journal. 2019;41(3):1-23. | 10 primary references (2 PubMed PMIDs) | 2026 |
| Hantavirus and Rodent Diseases in Philly A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Philly is a top-10 rat city. Hantavirus is rare here. Lepto, LCMV, and rat bite fever are the local risks that matter. A doctor's FAQ on what to know. Primary anchor: Centers for Disease Control and Prevention. "Reported Cases of Hantavirus Disease." Surveillance data, accessed 2026. | 8 primary references (2 PubMed PMIDs) | 2026 |
| Health for South Asians A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Care Coordination & Preventive Protocols) Why standard BMI lies for South Asians, why heart attacks come 10 years early, and the lab panel that catches risk in time. Primary anchor: MASALA Study. "Publications." Mediators of Atherosclerosis in South Asians Living in America cohort, UCSF. | 7 primary references (2 PubMed PMIDs) | 2026 |
| Medicinal Mushrooms: What Works A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Which medicinal mushrooms are backed by clinical evidence vs marketing hype? A doctor walks through PSK, lion's mane, reishi, and cordyceps. Primary anchor: Memorial Sloan Kettering Cancer Center. "Coriolus versicolor." Integrative Medicine reference, accessed 2026. | 7 primary references (2 PubMed PMIDs) | 2026 |
| When You Never Got Better A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) Still sick months after an infection, while every test says normal. Post-viral illness is a recognized diagnosis, and a careful workup finds the treatable pieces. Primary anchor: Soriano JB, Murthy S, Marshall JC, Relan P, Diaz JV; WHO Clinical Case Definition Working Group. "A clinical case definition of post-COVID-19 condition by a Delphi consensus." The Lancet Infectious Diseases. 2022;22(4):e102-e107. PubMed | 6 primary references (2 PubMed PMIDs) | 2026 |
| I Cut My Finger at Home: Do I Need Stitches? A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) A call with a new neighbor: triage a fresh kitchen cut in 60 seconds, skip the urgent care line, and avoid two common products. Primary anchor: Smack DP, Harrington AC, Dunn C, et al. (1996). "Infection and allergy incidence in ambulatory surgery patients using white petrolatum vs bacitracin ointment. A randomized controlled trial." JAMA, 276(12), 972-977. PMID: 8805732. | 4 primary references (2 PubMed PMIDs) | 2026 |
| NAC: The Lung & Liver Guardian A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Why NAC is called the 'master antioxidant builder.' Learn how this glutathione precursor protects your liver, clears brain fog, and fights urban oxidative stress. Primary anchor: Mokhtari, V., et al. (2017). A Review on Various Uses of N-Acetyl Cysteine. Cell Journal, 19(1), 11-17. | 4 primary references (2 PubMed PMIDs) | 2026 |
| Why We Choose a CT of the Chest A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Diagnostic Imaging & Biomarker Triage) When a chest CT beats an X-ray, what contrast adds, how lung nodules are followed, and what the radiation amounts to. Primary anchor: Mettler FA Jr, Huda W, Yoshizumi TT, Mahesh M. "Effective doses in radiology and diagnostic nuclear medicine: a catalog." Radiology. 2008;248(1):254-263. PubMed | 2 primary references (2 PubMed PMIDs) | 2026 |
| You Found a Breast Lump A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) What happens after you find a breast lump: why a lump you can feel needs a diagnostic mammogram, which test comes first, and how fast it should move. Primary anchor: Expert Panel on Breast Imaging; Klein KA, Kocher M, et al. "ACR Appropriateness Criteria: Palpable Breast Masses: 2022 Update." Journal of the American College of Radiology. 2023;20(5S):S146-S163. ScienceDirect | 15 primary references (1 PubMed PMIDs) | 2026 |
| Getting Answers from a Heart Monitor A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Diagnostic Imaging & Biomarker Triage) How to log palpitations with a Zio patch, use MyZio, protect sensitive skin, and understand what a longer heart recording can tell you. Primary anchor: American Heart Association. Warning Signs of a Heart Attack. | 11 primary references (1 PubMed PMIDs) | 2026 |
| Ticks: The First Hour, and How to Stop Getting Bitten A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) Pennsylvania reports more Lyme disease than any other state. How to remove a tick, when a single dose of doxycycline is the right call, and the treatment that goes on clothes. Primary anchor: Lantos PM, Rumbaugh J, Bockenstedt LK, et al. Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA), American Academy of Neurology (AAN), and American College of Rheumatology (ACR): 2020 Guidelines for the Prevention, Diagnosis and Treatment of Lyme Disease. Clinical Infectious Diseases. 2021;72(1):e1-e48. academic.oup.com | 7 primary references (1 PubMed PMIDs) | 2026 |
| D-MER: Sadness at Letdown A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) If you feel sudden dread, sadness, or anger right before milk lets down and it lifts in 90 seconds, you may have D-MER. It has a name, it is well described, and it can be managed. Primary anchor: Heise AM, Wiessinger D. (2011). "Dysphoric milk ejection reflex: A case report." International Breastfeeding Journal, 6:6. PMID 21645333. | 6 primary references (1 PubMed PMIDs) | 2026 |
| Cant Sleep? Fix the Root Cause. A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) Blackout curtains, chamomile tea, and you still wake at 3 AM. The metabolic, hormonal, and behavioral causes of insomnia, and the workup that finds yours. Primary anchor: Riemann D, et al. "European guideline for the diagnosis and treatment of insomnia." Journal of Sleep Research. 2017. | 5 primary references (1 PubMed PMIDs) | 2026 |
| Is My Body Mod Infected? A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) Tattoo or piercing looks angry? A doctors triage: normal healing vs true infection, the cartilage piercing exception, and when to call. Primary anchor: Centers for Disease Control and Prevention. (2012). "Tattoo-Associated Nontuberculous Mycobacterial Skin Infections - Multiple States, 2011-2012." MMWR. | 5 primary references (1 PubMed PMIDs) | 2026 |
| PCOS Is Now PMOS A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) PCOS was officially renamed PMOS (Polyendocrine Metabolic Ovarian Syndrome) in The Lancet, May 12, 2026. Why the rename matters and how to get diagnosed. Primary anchor: The Lancet. (2026). "Polyendocrine metabolic ovarian syndrome, the new name for polycystic ovary syndrome: a multistep global consensus process."00717-8/fulltext) The Lancet, published May 12, 2026. | 5 primary references (1 PubMed PMIDs) | 2026 |
| Considering Advocare Stoll Medical Group? A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Long waits, rotating providers, 15-minute visits. Why this happens at any large group, and what a continuous-care alternative looks like in Philly. Primary anchor: Pereira Gray DJ, Sidaway-Lee K, White E, Thorne A, Evans PH. (2018). "Continuity of care with doctors-a matter of life and death? A systematic review of continuity of care and mortality." BMJ Open, 8(6), e021161. | 4 primary references (1 PubMed PMIDs) | 2026 |
| What Testosterone Does A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Endocrinology & Reproductive Health) A doctor's guide to testosterone. What it really does, where it does not help, and the lifestyle changes that protect natural production. Primary anchor: Lincoff AM, Bhasin S, Flevaris P, et al. (2023). "Cardiovascular Safety of Testosterone-Replacement Therapy." New England Journal of Medicine. DOI: 10.1056/NEJMoa2215025. | 4 primary references (1 PubMed PMIDs) | 2026 |
| When You Need an Ultrasound, Body Part by Body Part A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Diagnostic Imaging & Biomarker Triage) What ultrasound answers for the thyroid, gallbladder, pelvis, veins, and more, how to prepare for each, and where it beats CT or MRI. Primary anchor: Tessler FN, Middleton WD, Grant EG, et al. "ACR Thyroid Imaging, Reporting and Data System (TI-RADS): White Paper of the ACR TI-RADS Committee." Journal of the American College of Radiology. 2017;14(5):587-595. PubMed | 2 primary references (1 PubMed PMIDs) | 2026 |
| Why We Choose an MRA, Territory by Territory A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Diagnostic Imaging & Biomarker Triage) What MR angiography answers for the brain, neck, kidneys, aorta, and legs, how it compares with CT angiography and ultrasound, and when contrast is used. Primary anchor: US Preventive Services Task Force. "Abdominal Aortic Aneurysm: Screening." Final Recommendation Statement, December 2019. USPSTF | 2 primary references (1 PubMed PMIDs) | 2026 |
| Still Not Yourself After Childbirth A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) Still not yourself months after delivery. Postpartum thyroiditis, low iron, depression and anxiety, and pelvic floor injury all have tests and treatments. Primary anchor: American College of Obstetricians and Gynecologists. "ACOG Committee Opinion No. 736: Optimizing Postpartum Care." Obstetrics & Gynecology. 2018;131(5):e140-e150. ACOG | 16 primary references | 2026 |
| What to Sort Out Before Your Trip A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Therapeutics & Pharmacology) A trip is booked. What to sort out and when: destination vaccines, malaria pills, the diarrhea plan, the kit. Ideally 4-6 weeks out; 1 week still counts. Primary anchor: Centers for Disease Control and Prevention. "Before You Travel." CDC Travelers' Health. CDC | 14 primary references | 2026 |
| When Your Practice Stops Calling Back A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Health Systems & Clinical Communication) Your doctor's office has gone quiet. How to get your records, your imaging, and your next test moving again, and when to stop waiting and get seen. Primary anchor: U.S. Department of Health & Human Services, Office for Civil Rights. "Individuals' Right under HIPAA to Access their Health Information, 45 CFR § 164.524." The governing federal guidance on scope, timelines, form and format, third-party directives, and permissible fees. | 14 primary references | 2026 |
| Hydration and Electrolytes: Why Drinking More Water Isn't the Answer A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Geroscience & Healthspan Medicine) Why plain water alone doesn't hydrate you, the role of sodium and potassium, and a practical daily protocol from a Philadelphia internal medicine physician. Primary anchor: Sterns RH. Disorders of plasma sodium - causes, consequences, and correction. New England Journal of Medicine. 2015;372(1):55-65. | 13 primary references | 2026 |
| Macular Degeneration: What Protects Your Vision, and Does AREDS2 Work? A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Geroscience & Healthspan Medicine) AREDS2 does not prevent macular degeneration for everyone, despite the pharmacy shelves. A grounded, evidence-based guide to who the eye vitamins help, what truly lowers your risk, and the new treatments, from Fishtown Medicine in Philadelphia. Primary anchor: Age-Related Eye Disease Study Research Group. "A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8." Archives of Ophthalmology. 2001;119(10):1417-1436. | 13 primary references | 2026 |
| Sleep Apnea: What Your Watch Knows, and Who Should Test A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Diagnostic Imaging & Biomarker Triage) Your watch can flag sleep apnea but cannot rule it out, and treating apnea has not been shown to prevent heart attacks. Who should be tested, and how to read an AHI. Primary anchor: Benjafield AV, Ayas NT, Eastwood PR, et al. "Estimation of the Global Prevalence and Burden of Obstructive Sleep Apnoea: A Literature-Based Analysis." Lancet Respiratory Medicine. 2019;7(8):687-698. | 13 primary references | 2026 |
| The Adult Vaccine Schedule, by Age A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Therapeutics & Pharmacology) Which vaccines adults need and when, as of 2026: flu each fall, shingles and pneumonia at 50, RSV, tetanus, hepatitis B, and the catch-ups adults miss. Primary anchor: Centers for Disease Control and Prevention. "Recommended Adult Immunization Schedule for Ages 19 Years or Older, United States." CDC / Schedule notes | 13 primary references | 2026 |
| Artificial Sweeteners and Erythritol: What the Evidence Says A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Metabolic Medicine & Bioenergetics) Stevia, erythritol, aspartame, allulose - are they safe? A grounded look at the erythritol clotting scare, the aspartame cancer headlines, and what the best evidence shows, from Fishtown Medicine in Philadelphia. Primary anchor: Witkowski M, Nemet I, Alamri H, et al. "The artificial sweetener erythritol and cardiovascular event risk." Nature Medicine. 2023;29(3):710-718. | 12 primary references | 2026 |
| How Much Protein? Muscle, Aging, and Longevity A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Exercise Physiology & Cardiorespiratory Fitness) The RDA for protein is a floor rather than a target. Here is how much protein the evidence supports for building muscle, defending against age-related loss, and aging well, plus the kidney myth and the plant-versus-animal question. Primary anchor: Rand WM, Pellett PL, Young VR. "Meta-Analysis of Nitrogen Balance Studies for Estimating Protein Requirements in Healthy Adults." American Journal of Clinical Nutrition. 2003;77(1):109-127. | 12 primary references | 2026 |
| Thyroid Nodules: What a Nodule on Your Scan Means A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Diagnostic Imaging & Biomarker Triage) Most thyroid nodules are benign, thyroid cancer diagnoses have tripled while deaths stayed low, and many small ones can be watched instead of cut. Here is what an incidental nodule really means and how it should be worked up. Primary anchor: Haugen BR, Alexander EK, Bible KC, et al. "2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer." Thyroid. 2016;26(1):1-133. | 12 primary references | 2026 |
| TMAO: What the Gut-Heart Marker Tells You A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Preventive Cardiology & Lipids) TMAO shows up on advanced cardiac panels and gets blamed on red meat and eggs. Here is what the gut-heart marker means, why fish complicates the story, and whether it is worth testing, from Fishtown Medicine in Philadelphia. Primary anchor: Wang Z, Klipfell E, Bennett BJ, et al. "Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease." Nature. 2011;472(7341):57-63. | 12 primary references | 2026 |
| When Lyme Symptoms Will Not Leave A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) Lingering symptoms after treated Lyme are recognized, and they have a workup. Fishtown Medicine believes you, grades the testing, and treats the treatable. Primary anchor: Aucott JN, Yang T, Yoon I, Powell D, Geller SA, Rebman AW. "Risk of post-treatment Lyme disease in patients with ideally-treated early Lyme disease: A prospective cohort study." International Journal of Infectious Diseases. 2022;116:230-237. Journal00035-2/fulltext) | 12 primary references | 2026 |
| How to Prevent Kidney Stones: What the Evidence Shows A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) The best way to prevent kidney stones is not to cut calcium. A grounded, evidence-based guide to fluid, diet, and the metabolic roots of stones, and when you need a workup, from Fishtown Medicine in Philadelphia. Primary anchor: Scales CD Jr, Smith AC, Hanley JM, Saigal CS. "Prevalence of kidney stones in the United States." European Urology. 2012;62(1):160-165. | 11 primary references | 2026 |
| IGF-1 and Growth Hormone: Why More Is Not Younger A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Geroscience & Healthspan Medicine) Longevity science points the opposite way from the anti-aging clinics: lower growth signaling tends to mean longer life, higher IGF-1 tracks with cancer, and growth hormone for aging is unproven and illegal. But lower is not the goal either. Primary anchor: Guevara-Aguirre J, Balasubramanian P, Guevara-Aguirre M, et al. "Growth Hormone Receptor Deficiency Is Associated with a Major Reduction in Pro-Aging Signaling, Cancer, and Diabetes in Humans." Science Translational Medicine. 2011;3(70):70ra13. | 11 primary references | 2026 |
| Vitamin B12 Deficiency: Why a Normal Level Can Miss It A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Diagnostic Imaging & Biomarker Triage) A normal serum B12 does not rule out deficiency, and nerve damage can come before anemia. Why metformin, acid blockers, and plant-based diets raise the risk, and what methylmalonic acid adds, from Fishtown Medicine in Philadelphia. Primary anchor: Stabler SP. "Vitamin B12 deficiency." New England Journal of Medicine. 2013;368(2):149-160. | 11 primary references | 2026 |
| When Your Insurance Says No: The Pennsylvania Appeal Playbook A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Health Systems & Clinical Communication) A Philadelphia internal medicine doctor's plain-language guide to fighting a health insurance denial in Pennsylvania - the internal appeal, the state's free Independent External Review (it overturned half the denials it saw in year one), and the phone number that fits every kind of plan. Primary anchor: Pennsylvania Independent External Review and the department's first-year results | 11 primary references | 2026 |
| High Ferritin: What It Means, from Iron Overload to Inflammation A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Diagnostic Imaging & Biomarker Triage) A high ferritin rarely means iron overload or hemochromatosis. What the number really reflects, why transferrin saturation is the test that sorts it out, and when it warrants a workup, from Fishtown Medicine in Philadelphia. Primary anchor: Allen KJ, Gurrin LC, Constantine CC, et al. "Iron-overload-related disease in HFE hereditary hemochromatosis." New England Journal of Medicine. 2008;358(3):221-230. | 10 primary references | 2026 |
| High GGT: What Your Gamma-Glutamyl Transferase Means A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Diagnostic Imaging & Biomarker Triage) A high GGT rarely means liver damage and never proves you drink too much. What the liver-panel enzyme reflects, why it predicts heart disease and diabetes, and how to read it, from Fishtown Medicine in Philadelphia. Primary anchor: Whitfield JB. "Gamma glutamyl transferase." Critical Reviews in Clinical Laboratory Sciences. 2001;38(4):263-355. | 10 primary references | 2026 |
| Losing Muscle on a GLP-1: How to Protect It A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Metabolic Medicine & Bioenergetics) A meaningful share of the weight lost on semaglutide or tirzepatide is muscle. What the body-composition data shows, why it matters for the long run, and the protein and training plan that protects it. Primary anchor: Wilding JPH, Batterham RL, Calanna S, et al. "Once-Weekly Semaglutide in Adults with Overweight or Obesity." New England Journal of Medicine. 2021;384(11):989-1002. | 10 primary references | 2026 |
| Philadelphia Invented the American Drugstore, Then Had to Police It A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) The first pharmacy school in America was founded in Philadelphia in 1821 to fix a market full of cure-alls. The story of how that went, and what it teaches about reading a health claim today. Primary anchor: Mütter Museum, The College of Physicians of Philadelphia. "Benjamin Rush, Bloodletting, and the Philadelphia Yellow Fever Epidemic of 1793." | 10 primary references | 2026 |
| Sauna Strategies: The Cardiovascular Mimetic A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Why sauna is a "cardiovascular mimetic" that may rival exercise for heart health. The science of heat shock proteins, our 20-at-175 strategy, dosing, and who should sit this one out. Primary anchor: Laukkanen T, et al. Association between sauna bathing and fatal cardiovascular and all-cause mortality events. JAMA Intern Med. 2015;175(4):542-548. | 10 primary references | 2026 |
| The Alzheimer's Blood Test: What It Means, Who Should Get It A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Geroscience & Healthspan Medicine) The first FDA-cleared Alzheimer's blood test detects brain pathology, not dementia, and a positive result in a person without symptoms does not mean disease. Here is what p-tau217 measures and who should and should not test. Primary anchor: Palmqvist S, Janelidze S, Quiroz YT, et al. "Discriminative Accuracy of Plasma Phospho-tau217 for Alzheimer Disease vs Other Neurodegenerative Disorders." JAMA. 2020;324(8):772-781. | 10 primary references | 2026 |
| The Heart Attack We Caught Seven Years Early A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Preventive Cardiology & Lipids) A 39-year-old case: how ApoB, Lp(a), and LDL particle number revealed cardiovascular risk a standard cholesterol panel and a zero calcium score had missed. Primary anchor: Sniderman AD, Thanassoulis G, Glavinovic T, et al. Apolipoprotein B Particles and Cardiovascular Disease: A Narrative Review. JAMA Cardiol. 2019;4(12):1287-1295. | 10 primary references | 2026 |
| The New Weight-Loss Drugs, Compared (2026) A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Metabolic Medicine & Bioenergetics) Semaglutide, tirzepatide, orforglipron, retatrutide, and CagriSema compared: mechanism, weight loss, route, and approval status. Which is strongest, which is a pill, which has proven heart benefit, and how to choose. Primary anchor: Wilding JPH, Batterham RL, Calanna S, et al. "Once-Weekly Semaglutide in Adults with Overweight or Obesity." New England Journal of Medicine. 2021;384(11):989-1002. | 10 primary references | 2026 |
| What Low Libido Is Telling You A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) Low libido is a signal worth working up. Fishtown Medicine looks for the cause across hormones, blood flow, sleep, and stress, in men and women in Philadelphia. Primary anchor: Bhasin S, et al. "Testosterone therapy in men with hypogonadism: an Endocrine Society clinical practice guideline." Journal of Clinical Endocrinology & Metabolism. 2018. | 10 primary references | 2026 |
| What to Eat, Starting With Breakfast A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Metabolic Medicine & Bioenergetics) The 5 food groups you can eat freely, why breakfast should be your biggest meal, and a long list of breakfast options that are more than a small yogurt. Primary anchor: Jakubowicz D, Barnea M, Wainstein J, Froy O. "High caloric intake at breakfast vs. dinner differentially influences weight loss of overweight and obese women." Obesity. 2013. | 10 primary references | 2026 |
| Colon Cancer in Young Adults: The Rise and the Red Flags A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Diagnostic Imaging & Biomarker Triage) Colon and rectal cancer are rising in people under 50, and young patients are often diagnosed late because symptoms get blamed on hemorrhoids. Here is the true scale of the trend, the red flags, and who needs earlier evaluation. Primary anchor: Siegel RL, Fedewa SA, Anderson WF, et al. "Colorectal Cancer Incidence Patterns in the United States, 1974-2013." Journal of the National Cancer Institute. 2017;109(8):djw322. | 9 primary references | 2026 |
| Enlarged Prostate (BPH): Symptoms and What Works A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) An enlarged prostate is common with age, it is not cancer and does not become cancer, and saw palmetto does not help. Here are the symptoms, how it is evaluated, and the treatments that work. Primary anchor: Berry SJ, Coffey DS, Walsh PC, Ewing LL. "The Development of Human Benign Prostatic Hyperplasia with Age." Journal of Urology. 1984;132(3):474-479. | 9 primary references | 2026 |
| GLP-1 Drugs and Heart Failure: What HFpEF Changes A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Preventive Cardiology & Lipids) GLP-1 drugs help one specific kind of heart failure, the obesity-driven HFpEF, and may not help another. What STEP-HFpEF and SUMMIT showed, why the type of heart failure matters, and how this differs from SGLT2 inhibitors. Primary anchor: Obokata M, Reddy YNV, Pislaru SV, Melenovsky V, Borlaug BA. "Evidence Supporting the Existence of a Distinct Obese Phenotype of Heart Failure with Preserved Ejection Fraction." Circulation. 2017;136(1):6-19. | 9 primary references | 2026 |
| SGLT2 Inhibitors: Heart, Kidney, and the Longevity Question A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Metabolic Medicine & Bioenergetics) SGLT2 inhibitors (Jardiance, Farxiga) protect the heart and kidneys, even in people without diabetes, and carry a mouse-longevity signal. The trial evidence, the longevity question, dosing, and the safety points that matter. Primary anchor: Zinman B, Wanner C, Lachin JM, et al. "Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes." New England Journal of Medicine. 2015;373(22):2117-2128. | 9 primary references | 2026 |
| When Your Pain Has No Name Yet A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) Months of pain, normal tests, told it is stress or age. How a pain workup goes, what each normal result narrows, and when pain gets its name. Primary anchor: Nicholas M, Vlaeyen JWS, Rief W, et al. "The IASP classification of chronic pain for ICD-11: chronic primary pain." Pain. 2019;160(1):28-37. DOI | 9 primary references | 2026 |
| A Positive ANA: What an Antinuclear Antibody Result Means A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Diagnostic Imaging & Biomarker Triage) A positive ANA rarely means lupus. Why the antinuclear antibody test is positive in about 1 in 7 healthy adults, why titer and symptoms decide what it means, and when it matters, from Fishtown Medicine in Philadelphia. Primary anchor: Satoh M, Chan EKL, Ho LA, et al. "Prevalence and sociodemographic correlates of antinuclear antibodies in the United States." Arthritis & Rheumatism. 2012;64(7):2319-2327. | 8 primary references | 2026 |
| AMH Testing: What Your Ovarian Reserve Number Means A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Endocrinology & Reproductive Health) A low AMH does not mean you will struggle to conceive naturally, and a high one is not a buffer against your age. Here is what ovarian reserve testing measures, where it helps, and where the direct-to-consumer version misleads. Primary anchor: Punchoo R, Bhoora S. "Variation in the Measurement of Anti-Mullerian Hormone: What Are the Laboratory Issues?" Frontiers in Endocrinology. 2021;12:719029. | 8 primary references | 2026 |
| Can You Reverse Type 2 Diabetes? What Remission Really Means A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Metabolic Medicine & Bioenergetics) Type 2 diabetes can go into remission for many people through substantial weight loss. What the DiRECT trial showed, why doctors say remission instead of cure, the GLP-1 nuance, who is most likely to succeed, and how durable it is. Primary anchor: Riddle MC, Cefalu WT, Evans PH, et al. "Consensus Report: Definition and Interpretation of Remission in Type 2 Diabetes." Diabetes Care. 2021;44(10):2438-2444. | 8 primary references | 2026 |
| Fisetin: The Senolytic Flavonoid in Your Strawberries A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) An evidence-based guide to fisetin: how this plant flavonoid works as a senolytic, what the mouse data and early human trials show, and why strawberries come first. Primary anchor: Yousefzadeh MJ, Zhu Y, McGowan SJ, et al. Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine. 2018;36:18-28. | 8 primary references | 2026 |
| GERD and Gastritis: What Is Driving the Burn A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Stop relying on Tums. Learn how a Philadelphia internal medicine clinic finds the root cause of acid reflux and gastritis instead of just suppressing symptoms. Primary anchor: Kahrilas PJ, et al. American Gastroenterological Association Medical Position Statement on the Management of Gastroesophageal Reflux Disease. Gastroenterology. 2008;135(4):1383-1391. | 8 primary references | 2026 |
| High Troponin and NT-proBNP: Reading Cardiac Markers A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Preventive Cardiology & Lipids) A high troponin on a longevity panel is not proof of a silent heart attack, and a normal NT-proBNP can mislead in obesity. Here is what these cardiac blood markers mean when you are not in the emergency room. Primary anchor: Thygesen K, Alpert JS, Jaffe AS, et al. "Fourth Universal Definition of Myocardial Infarction (2018)." Circulation. 2018;138(20):e618-e651. | 8 primary references | 2026 |
| Low-Dose Colchicine for Cardiovascular Prevention A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Preventive Cardiology & Lipids) Low-dose colchicine (0.5 mg) targets the inflammation behind heart disease. What COLCOT and LoDoCo2 showed, why the 2025 CLEAR SYNERGY trial found no benefit, and who it is for. Primary anchor: Ridker PM, Everett BM, Thuren T, et al. "Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease." New England Journal of Medicine. 2017;377(12):1119-1131. | 8 primary references | 2026 |
| Nervous About Statins? When Your Family Can't Tolerate Them, and What Else Works A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Preventive Cardiology & Lipids) Both parents had bad reactions to statins, and you're worried you will too? Why intolerance rarely runs the way people fear, and the full menu of options when a statin isn't the right fit. Primary anchor: Wood FA, Howard JP, Finegold JA, et al. N-of-1 Trial of a Statin, Placebo, or No Treatment to Assess Side Effects (SAMSON). New England Journal of Medicine. 2020;383(22):2182-2184. | 8 primary references | 2026 |
| Postpartum Care in Philadelphia A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Care Coordination & Preventive Protocols) What good postpartum care looks like in Philadelphia, the gap in the standard 6-week check, and how a primary care relationship carries new moms through the first year. Primary anchor: ACOG Committee Opinion No. 736 (2018). Optimizing Postpartum Care. Obstetrics & Gynecology 131(5):e140-e150. | 8 primary references | 2026 |
| Propranolol, from the prescribing side A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Therapeutics & Pharmacology) What propranolol does to adrenaline, the dose and timing people use before an event, the interactions that change the answer, and the conditions that make it unsafe. Primary anchor: Brantigan CO, Brantigan TA, Joseph N. Effect of beta blockade and beta stimulation on stage fright. The American Journal of Medicine. 1982;72(1):88-94. | 8 primary references | 2026 |
| Skin Cancer Screening: Who Benefits, Done Right A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Diagnostic Imaging & Biomarker Triage) A yearly full-body skin scan is not proven to save average-risk lives, and much of the melanoma rise is overdiagnosis. Here is who is high risk, how to screen well, and why phone apps and gene stickers are oversold. Primary anchor: US Preventive Services Task Force. "Screening for Skin Cancer: US Preventive Services Task Force Recommendation Statement." JAMA. 2023;329(15):1290-1295. | 8 primary references | 2026 |
| Social Health Is Healthspan A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) More than 80 years of research connects relationships and community to how long and how well you live. A Philadelphia doctor on what to do about it day to day. Primary anchor: Holt-Lunstad, J., et al. (2010). Social Relationships and Mortality Risk: A Meta-analytic Review. PLOS Medicine, 7(7), e1000316. | 8 primary references | 2026 |
| The Four Horsemen: A Longevity Framework A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Health Systems & Clinical Communication) Atherosclerotic disease, cancer, neurodegeneration, and metabolic dysfunction: the 4 Horsemen that end most lives, the term Peter Attia popularized in Outlive, and how a Philadelphia doctor screens for each one decades early. Primary anchor: Attia P. Outlive: The Science and Art of Longevity. Harmony/Rodale; 2023. The book that popularized the Four Horsemen framing and the Medicine 3.0 model. | 8 primary references | 2026 |
| The Performance Physical: 4 Numbers That Predict How You'll Age A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) A performance physical measures how well you are aging: VO2 max, grip strength, mobility, and body composition - the 4 tests that predict healthspan. Primary anchor: Mandsager K, et al. Association of Cardiorespiratory Fitness With Long-term Mortality Among Adults Undergoing Exercise Treadmill Testing. JAMA Network Open. 2018;1(6):e183605. | 8 primary references | 2026 |
| The Sexual Health Playbook A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Care Coordination & Preventive Protocols) Erectile dysfunction, low libido, premature ejaculation, and performance anxiety are usually early signals of something systemic. Here is the full workup. Primary anchor: Inman BA, et al. "A Population-Based, Longitudinal Study of Erectile Dysfunction and Future Coronary Artery Disease." Mayo Clinic Proceedings. 2009;84(2):108-113. | 8 primary references | 2026 |
| The Skin Playbook A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Care Coordination & Preventive Protocols) Acne, dandruff, cold sores, and skin aging are usually downstream of hormones, metabolism, sleep, and inflammation. How a primary care doctor reads the signs. Primary anchor: Reynolds RV, et al. "Guidelines of Care for the Management of Acne Vulgaris." Journal of the American Academy of Dermatology. 2024. | 8 primary references | 2026 |
| Unintended Weight Gain: Finding the Metabolic Cause A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) Weight gain is not a willpower problem. Learn how Fishtown Medicine finds the hormonal, metabolic, and emotional drivers behind unintended weight gain. Primary anchor: Fothergill E, et al. Persistent metabolic adaptation 6 years after "The Biggest Loser" competition. Obesity (Silver Spring). 2016;24(8):1612-1619. | 8 primary references | 2026 |
| When You or a Neighbor Needs Help in Philadelphia A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Geroscience & Healthspan Medicine) A Philadelphia doctor's directory of the city help that matters for health - cooling centers, Code Blue, utility assistance, home repair - with phone numbers. Primary anchor: City of Philadelphia - Heat health emergency and the Extreme heat guide | 8 primary references | 2026 |
| Adult Autism Diagnosis: How It Works, and the Tools Behind It A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Autism is often missed in adults, particularly women and anyone who learned to mask. How adult autism is diagnosed and the validated tools clinicians use. Primary anchor: American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision (DSM-5-TR). Washington, DC: APA; 2022. | 7 primary references | 2026 |
| Antibiotics and Your Gut Microbiome A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) What antibiotics do to your gut, why a probiotic supplement usually is not the answer, and the 3 habits that rebuild your microbiome. Primary anchor: Suez, J., et al. (2018). Post-antibiotic gut mucosal microbiome reconstitution is impaired by probiotics and improved by autologous FMT. Cell, 174(6), 1406-1423. | 7 primary references | 2026 |
| Bedbugs: How to Know, and What to Do First A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) Bites cannot tell you whether you have bedbugs. What settles it, the 2 moves that make an infestation worse, and what Philadelphia renters can require of a landlord. Primary anchor: Goddard J, deShazo R. Bed Bugs (Cimex lectularius) and Clinical Consequences of Their Bites. JAMA. 2009;301(13):1358-1366. jamanetwork.com | 7 primary references | 2026 |
| Bladder Pain When Every Urine Culture Comes Back Negative A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) Bladder pain and urgency with repeatedly negative cultures is often interstitial cystitis. Why antibiotics keep failing, why Kegels can make it worse, and what the guidelines now recommend. Primary anchor: Clemens JQ, Erickson DR, Varela NP, Lai HH. Diagnosis and Treatment of Interstitial Cystitis/Bladder Pain Syndrome. The Journal of Urology. 2022;208(1):34-42. | 7 primary references | 2026 |
| Chest Wall Pain: When Pressing on It Recreates the Pain A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) Chest pain you can reproduce by pressing is often costochondritis. How it differs from cardiac pain, why tenderness alone never settles the question, and what treatment involves. Primary anchor: Mott T, Jones G, Roman K. Costochondritis: Rapid Evidence Review. American Family Physician. 2021;104(1):73-78. | 7 primary references | 2026 |
| Do Antioxidant Supplements Work? A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Oxidative stress harms your cells, yet antioxidant supplements mostly fail in trials and sometimes cause harm. Why flooding your cells backfires, and what to do instead, from Fishtown Medicine in Philadelphia. Primary anchor: Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C. "Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases." Cochrane Database of Systematic Reviews. 2012;(3):CD007176. | 7 primary references | 2026 |
| Frozen Shoulder: What It Says About Your Blood Sugar A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) A shoulder that freezes without an injury is often a metabolic signal. The blood sugar link, why the capsule stiffens, and what to check before you wait. Primary anchor: Zreik NH, Malik RA, Charalambous CP. Adhesive capsulitis of the shoulder and diabetes: a meta-analysis of prevalence. Muscles, Ligaments and Tendons Journal. 2016;6(1):26-34. | 7 primary references | 2026 |
| GER·O·SPAN A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Health Systems & Clinical Communication) GER (Genetics, Environment, Relationships) on one side, SPAN (Sleep, Physical Activity, Nutrition) on the other, and O, our shared work, as the fulcrum. All seven are worked on together, aimed at the targets you set and the outcomes you came in for. Primary anchor: Kodama S, et al. "Cardiorespiratory Fitness as a Quantitative Predictor of All-Cause Mortality and Cardiovascular Events in Healthy Men and Women." JAMA. 2009. | 7 primary references | 2026 |
| GLP-1s and Your Brain A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) A Philadelphia doctor on what emerging research says about GLP-1s and the brain: food noise, 'Ozempic personality,' addiction, mood, and what to watch for. Primary anchor: Wilding, J. P. H., et al. (2021). Once-Weekly Semaglutide in Adults with Overweight or Obesity (STEP 1). New England Journal of Medicine, 384(11), 989-1002. | 7 primary references | 2026 |
| Healthspan vs Lifespan: The Years That Matter A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Americans live to about 78 but spend the last 12 years sick and dependent. A Philadelphia primary care practice on why healthspan is the better metric. Primary anchor: Arias E, Xu J. United States Life Tables, 2023. National Vital Statistics Reports. CDC. 2024. | 7 primary references | 2026 |
| Hidradenitis Suppurativa: The Inflammation Behind Recurring Boils A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Painful lumps in the armpits or groin that keep coming back are usually an immune condition rather than an infection. The mechanism, the metabolic link, and what works. Primary anchor: Sabat R, Jemec GBE, Matusiak Ł, Kimball AB, Prens E, Wolk K. Hidradenitis suppurativa. Nature Reviews Disease Primers. 2020;6(1):18. | 7 primary references | 2026 |
| High Fibrinogen: What It Means for Your Heart A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Preventive Cardiology & Lipids) A high fibrinogen predicts heart risk but is not a treatment target. What the clotting-and-inflammation marker reflects, why genetics say it is a messenger not a cause, and how to respond, from Fishtown Medicine in Philadelphia. Primary anchor: Fibrinogen Studies Collaboration; Danesh J, Lewington S, Thompson SG, et al. "Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analysis." JAMA. 2005;294(14):1799-1809. | 7 primary references | 2026 |
| How I Decide to Prescribe A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) A Philadelphia doctor on choosing the right drug, the right dose, the shortest effective duration, and when to leave the prescription pad alone. Primary anchor: Llor, C., & Bjerrum, L. (2014). Antimicrobial resistance: risk associated with antibiotic overuse and initiatives to reduce the problem. Therapeutic Advances in Drug Safety, 5(6), 229-241. | 7 primary references | 2026 |
| Jaywalking Was Invented, and It Changed Who the Street Belonged To A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Before the 1920s, streets were shared space and children played in them. The auto industry ran a campaign that made walking the crime. What Philadelphia's speed cameras prove about design as a health intervention. Primary anchor: Norton PD. Fighting Traffic: The Dawn of the Motor Age in the American City. MIT Press; 2008. The foundational scholarly account of the 1920s campaign. | 7 primary references | 2026 |
| July in Philly: A Doctor's Guide to the Month A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) A Philadelphia doctor's guide to July: staying hydrated in the humidity, a shore kit that covers what goes sideways, sleeping through rowhome heat, and keeping cookout season easy on your body. Primary anchor: Semenza, J. C., Rubin, C. H., Falter, K. H., et al. (1996). Heat-related deaths during the July 1995 heat wave in Chicago. New England Journal of Medicine, 335(2), 84-90. | 7 primary references | 2026 |
| Lipedema: When Diet and Exercise Never Touch Your Legs A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Painful, symmetrical fat on the legs that resists dieting is a recognized condition rather than a willpower problem. How lipedema is diagnosed, what helps, and where the evidence is still thin. Primary anchor: Buck DW 2nd, Herbst KL. Lipedema: A Relatively Common Disease with Extremely Common Misconceptions. Plastic and Reconstructive Surgery Global Open. 2016;4(9):e1043. | 7 primary references | 2026 |
| Lp-PLA2 (the PLAC Test): What It Means for Your Heart A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Preventive Cardiology & Lipids) A high Lp-PLA2, or PLAC test, carries a modest heart-risk signal but is not a treatment target. Why a drug built to lower it failed in two large trials, and what to do instead, from Fishtown Medicine in Philadelphia. Primary anchor: Thompson A, Gao P, Orfei L, et al; Lp-PLA2 Studies Collaboration. "Lipoprotein-associated phospholipase A2 and risk of coronary disease, stroke, and mortality: collaborative analysis of 32 prospective studies." The Lancet. 2010;375(9725):1536-1544. | 7 primary references | 2026 |
| Lung Cancer Screening: Who Needs a Low-Dose CT, and What to Expect A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Diagnostic Imaging & Biomarker Triage) A low-dose CT lung scan saves lives, but only for the right people. Who qualifies, what the evidence shows, the trade-offs, and why a whole-body MRI does not cover your lungs, from Fishtown Medicine in Philadelphia. Primary anchor: Aberle DR, Adams AM, Berg CD, et al. "Reduced lung-cancer mortality with low-dose computed tomographic screening." New England Journal of Medicine. 2011;365(5):395-409. | 7 primary references | 2026 |
| Menopause 3.0: Why Hormone Optimization Is a Longevity Strategy A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Move beyond symptom relief. A Philadelphia primary care practice using bio-identical hormone therapy and lifestyle care to protect brain, bone, and heart health. Primary anchor: Rossouw JE, et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial. JAMA. 2002;288(3):321-333. | 7 primary references | 2026 |
| Migraine: A Brain Running Low on Energy A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Migraine may be a sign the brain runs low on energy reserve. The metabolic fragility lens, what the evidence shows, and the counterpoints. Primary anchor: Gross EC, Lisicki M, Fischer D, Sándor PS, Schoenen J. The metabolic face of migraine - from pathophysiology to treatment. Nature Reviews Neurology. 2019;15(11):627-643. | 7 primary references | 2026 |
| Muscle Is the Organ of Longevity A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Exercise Physiology & Cardiorespiratory Fitness) Muscle mass and strength predict how long and how well you live, and both are buildable at any age. Why sarcopenia matters, what the evidence shows, and how Fishtown Medicine builds strength into a longevity plan in Philadelphia. Primary anchor: Leong DP, Teo KK, Rangarajan S, et al. "Prognostic value of grip strength: findings from the Prospective Urban Rural Epidemiology (PURE) study." Lancet. 2015;386(9990):266-273. | 7 primary references | 2026 |
| Muscle Twitching: What It Means and When It Matters A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) Muscle twitching is common and usually benign. What the long-term evidence shows about the ALS fear, the pattern that would change the picture, and the workup you deserve. Primary anchor: Blexrud MD, Windebank AJ, Daube JR. Long-term follow-up of 121 patients with benign fasciculations. Annals of Neurology. 1993;34(4):622-625. | 7 primary references | 2026 |
| Perimenopause: The Window of Opportunity A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Endocrinology & Reproductive Health) Frozen shoulder? Palpitations? Anxiety? It might be perimenopause. Dr. Ash helps Philadelphia women move through the transition with validation, data, and modern HRT. Primary anchor: The 2022 Hormone Therapy Position Statement of The North American Menopause Society. Menopause. 2022;29(7):767-794. | 7 primary references | 2026 |
| Primary Aldosteronism: The Curable High Blood Pressure Doctors Miss A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Preventive Cardiology & Lipids) Primary aldosteronism causes 5 to 10% of high blood pressure and up to a fifth of resistant cases, yet fewer than 2% get tested. Why it harms the heart beyond the numbers, who should be screened, and how it can be cured. Primary anchor: Monticone S, Burrello J, Tizzani D, et al. "Prevalence and Clinical Manifestations of Primary Aldosteronism Encountered in Primary Care Practice." Journal of the American College of Cardiology. 2017;69(14):1811-1820. | 7 primary references | 2026 |
| Restless Legs: A Brain Running Low on Iron A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Restless legs syndrome is usually a brain iron problem rather than a nerve or vein problem. The brain-iron lens, the ferritin most labs miss, and the fix. Primary anchor: Allen RP, Barker PB, Wehrl F, Song HK, Earley CJ. MRI measurement of brain iron in patients with restless legs syndrome. Neurology. 2001;56(2):263-265. | 7 primary references | 2026 |
| Self-Injury: A Compassionate Clinical Guide A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) What non-suicidal self-injury (NSSI) is, why it happens, and how to find your way out. A stigma-free guide for patients, parents, and partners. Primary anchor: International Society for the Study of Self-Injury (ISSS). What is self-injury? 2024. | 7 primary references | 2026 |
| Tallow: What's Validated A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Beef tallow is back in kitchens and skincare. What the evidence supports, and what it does not, from a doctor's perspective. Primary anchor: Bonanome A, Grundy SM. (1988 / republished context). "Role of beef and beef tallow, an enriched source of stearic acid, in a cholesterol-lowering diet." American Journal of Clinical Nutrition. | 7 primary references | 2026 |
| The Alpha-Gal Syndrome Playbook A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Care Coordination & Preventive Protocols) The tick-triggered red meat allergy that has moved into the Delaware Valley, and the test that keeps falling through the cracks in 7-minute visits. Primary anchor: Commins, S. P., et al. (2009). Delayed anaphylaxis, angioedema, or urticaria after consumption of red meat in patients with IgE antibodies specific for galactose-alpha-1,3-galactose. Journal of Allergy and Clinical Immunology, 123(2), 426-433. | 7 primary references | 2026 |
| The Biology of Despair: Why Emotional Health Is a Survival Metric A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Suicide and overdose are leading causes of death for adults under 45. How a Philadelphia primary care practice integrates emotional health into longevity care. Primary anchor: Case A, Deaton A. Deaths of Despair and the Future of Capitalism. Princeton University Press; 2020. | 7 primary references | 2026 |
| The Hair Playbook A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Care Coordination & Preventive Protocols) Hair shedding usually points to a driver you can fix. The labs that find it (ferritin, thyroid, hormones), what the evidence supports, and what to skip. Primary anchor: Trost LB, Bergfeld WF, Calogeras E. "The diagnosis and treatment of iron deficiency and its potential relationship to hair loss." Journal of the American Academy of Dermatology. 2006;54(5):824-844. | 7 primary references | 2026 |
| The Headache That Gets Worse When You Bend, Cough, or Strain A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) A headache that presses at the crown, feels heavy behind the eyes, wakes you from sleep, and worsens with straining can mean raised pressure around the brain. A dilated eye exam is the test that opens or closes it. Primary anchor: Friedman DI, Liu GT, Digre KB. "Revised Diagnostic Criteria for the Pseudotumor Cerebri Syndrome in Adults and Children." Neurology. 2013;81(13):1159-1165. | 7 primary references | 2026 |
| The question that has to come first A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) Sleep apnea often presents as insomnia, particularly in women. Why sedating an undiagnosed apnea is the mistake to avoid, and how the two are separated. Primary anchor: Sweetman AM, Lack LC, Catcheside PG, et al. Developing a successful treatment for co-morbid insomnia and sleep apnoea. Sleep Medicine Reviews. 2017;33:28-38. | 7 primary references | 2026 |
| The treatment that outlasts the pill A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Therapeutics & Pharmacology) Every major guideline says to try CBT-I before a sleeping pill. What the five parts are, why sleep restriction is the active ingredient, and who it is wrong for. Primary anchor: Qaseem A, Kansagara D, Forciea MA, Cooke M, Denberg TD. Management of Chronic Insomnia Disorder in Adults: A Clinical Practice Guideline From the American College of Physicians. Annals of Internal Medicine. 2016;165(2):125-133. | 7 primary references | 2026 |
| Tinnitus: The Sound Your Brain Is Making A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) Ringing in the ears usually starts in the brain rather than the ear. Why the volume gets turned up, which symptoms are urgent, and what the evidence supports. Primary anchor: Tunkel DE, Bauer CA, Sun GH, et al. Clinical Practice Guideline: Tinnitus. Otolaryngology-Head and Neck Surgery. 2014;151(2 Suppl):S1-S40. | 7 primary references | 2026 |
| Tirzepatide (Zepbound, Mounjaro): The Dual Incretin Drug A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Metabolic Medicine & Bioenergetics) Tirzepatide (Zepbound, Mounjaro) is the dual GIP/GLP-1 drug that outperformed semaglutide for weight loss. What the trials show for weight, diabetes, heart failure, and sleep apnea, and the limits of its heart evidence. Primary anchor: Jastreboff AM, Aronne LJ, Ahmad NN, et al. "Tirzepatide Once Weekly for the Treatment of Obesity." New England Journal of Medicine. 2022;387(3):205-216. | 7 primary references | 2026 |
| Vertigo: When the Room Spins as You Roll Over A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) Brief spinning triggered by head movement is usually BPPV, caused by loose crystals in the inner ear. Why a maneuver treats it better than medication, and the symptoms that mean something else. Primary anchor: Bhattacharyya N, Gubbels SP, Schwartz SR, et al. Clinical Practice Guideline: Benign Paroxysmal Positional Vertigo (Update). Otolaryngology-Head and Neck Surgery. 2017;156(3_suppl):S1-S47. | 7 primary references | 2026 |
| Waking at three, drenched, for two years A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Endocrinology & Reproductive Health) Why sleep falls apart in the menopause transition, why sleep apnea risk rises at the same time, and the treatments that address the cause instead of sedating the symptom. Primary anchor: Baker FC, de Zambotti M, Colrain IM, Bei B. Sleep problems during the menopausal transition: prevalence, impact, and management challenges. Nature and Science of Sleep. 2018;10:73-95. | 7 primary references | 2026 |
| What Sets Your Asthma Off A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) The triggers that matter most, why infections beat allergens for adults, what to change at home first, and the 4 questions that tell you control is slipping. Primary anchor: American Lung Association. "Reduce Asthma Triggers" and "Clean Air at Home." Updated 2026. | 7 primary references | 2026 |
| What the NHS-Galleri Trial Showed (And What It Means For Your Screening) A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Geroscience & Healthspan Medicine) What the 142,000-person NHS trial of the Galleri multi-cancer blood test proved over 3 years, and the plain read on what it means for cancer screening. Primary anchor: Swanton C. NHS-Galleri: Primary Results From a Randomised Controlled Trial to Assess the Clinical Utility of a Multi-Cancer Early Detection (MCED) Test in Population Screening. American Society of Clinical Oncology (ASCO) Annual Meeting; 2026 May 29-June 2. | 7 primary references | 2026 |
| Why Your "Normal" LDL Can Hide Heart Risk A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Standard cholesterol panels miss most heart attacks. See how a Philadelphia preventive cardiology approach uses ApoB, Lp(a), and modern imaging to catch risk early. Primary anchor: Strong JP, et al. Prevalence and extent of atherosclerosis in adolescents and young adults. JAMA. 1999;281(8):727-735. The landmark PDAY study establishing that heart disease begins in childhood. | 7 primary references | 2026 |
| Your Watch Flagged AFib: What to Do Next A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Preventive Cardiology & Lipids) A smartwatch irregular-rhythm alert is a screening flag rather than a diagnosis. How accurate the wearables are, why atrial fibrillation matters, what a proper workup looks like, and how lifestyle can lower AFib, without self-treating. Primary anchor: Van Gelder IC, Rienstra M, Bunting KV, et al. "2024 ESC Guidelines for the Management of Atrial Fibrillation Developed in Collaboration with the EACTS." European Heart Journal. 2024;45(36):3314-3414. | 7 primary references | 2026 |
| 3mg and 150mg are not the same medicine A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Therapeutics & Pharmacology) At 3mg to 6mg, doxepin is a selective antihistamine approved for sleep maintenance. At antidepressant doses it is a tricyclic with all that implies. The gap is the whole story. Primary anchor: US Food and Drug Administration. Silenor (doxepin) tablets prescribing information. FDA Access Data. | 6 primary references | 2026 |
| Acarbose: The Diabetes Drug With a Longevity Signal A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Metabolic Medicine & Bioenergetics) Acarbose is an old diabetes drug with a striking mouse-longevity signal. What it does, why longevity researchers watch it, what it is proven to do in people (diabetes prevention rather than heart protection), and its side effects. Primary anchor: Harrison DE, Strong R, Allison DB, et al. "Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males." Aging Cell. 2014;13(2):273-282. | 6 primary references | 2026 |
| Air Quality in Philadelphia: What to Do at Every AQI A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Geroscience & Healthspan Medicine) A Philadelphia doctor on what the Air Quality Index measures, who is at higher risk, and what to do at every tier, from normal days to wildfire smoke. Primary anchor: Pope, C. A., 3rd, Burnett, R. T., Thun, M. J., et al. (2002). Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution. JAMA, 287(9), 1132-1141. | 6 primary references | 2026 |
| Behind the screen, the tremor is the whole verdict A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Exercise Physiology & Cardiorespiratory Fitness) Music performance anxiety has its own literature and its own occupational reality. What works, what beta-blockers do, and how to tell nerves from something larger. Primary anchor: Brantigan CO, Brantigan TA, Joseph N. Effect of beta blockade and beta stimulation on stage fright. The American Journal of Medicine. 1982;72(1):88-94. | 6 primary references | 2026 |
| Beta-Sitosterol: What the Evidence Supports A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Evidence-based guide to beta-sitosterol. The phytosterol mechanism, the trial data for LDL cholesterol and prostate (BPH) symptoms, the limits, dosing, and quality. Primary anchor: Berges, R. R., Windeler, J., Trampisch, H. J., & Senge, T. (1995). Randomised, placebo-controlled, double-blind clinical trial of beta-sitosterol in patients with benign prostatic hyperplasia. The Lancet, 345(8964), 1529-1532. | 6 primary references | 2026 |
| Borderline Cholesterol: How ApoB, Lp(a), and Blood Pressure Change the Plan A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Preventive Cardiology & Lipids) A 47-year-old with "borderline" LDL, a father who had a heart attack at 60, and a blood pressure nobody was tracking. How ApoB, Lp(a), and home BP turned "recheck in a year" into a plan. Primary anchor: Sniderman AD, Thanassoulis G, Glavinovic T, et al. Apolipoprotein B Particles and Cardiovascular Disease: A Narrative Review. JAMA Cardiol. 2019;4(12):1287-1295. | 6 primary references | 2026 |
| Cold Plunge and Cold Exposure: Hype vs Evidence A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Geroscience & Healthspan Medicine) Cold plunges boost mood and alertness and can ease muscle soreness, but the longevity evidence is thinner than for sauna, and timing around lifting matters. a look, plus how Fishtown Medicine weighs it in Philadelphia. Primary anchor: Šrámek P, Šimečková M, Janský L, Šavlíková J, Vybíral S. "Human physiological responses to immersion into water of different temperatures." European Journal of Applied Physiology. 2000;81(5):436-442. | 6 primary references | 2026 |
| Cold Sores (Oral Herpes) A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) Cold sores are caused by a virus most adults already carry. Why they come back, how to stop an outbreak at the first tingle, and when a daily antiviral is worth it. Primary anchor: James C, et al. "Herpes simplex virus: global infection prevalence and incidence estimates, 2016." Bulletin of the World Health Organization. 2020;98(5):315-329. | 6 primary references | 2026 |
| Do I Need Antibiotics? A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Therapeutics & Pharmacology) Sinus infection, bronchitis, cold, sore throat, and UTI. What the criteria are for each, which ones need antibiotics, and what helps otherwise. Primary anchor: Centers for Disease Control and Prevention. "Outpatient Clinical Care for Adults." Antibiotic Prescribing and Use. Updated 2024. | 6 primary references | 2026 |
| Fatty Liver (MASLD): How Serious It Is and How to Reverse It A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Metabolic Medicine & Bioenergetics) Fatty liver (MASLD) is now the most common liver condition in the world, and in its early stages it is reversible. What the diagnosis means, how it is staged without a biopsy, and how Fishtown Medicine treats it in Philadelphia. Primary anchor: Rinella ME, Lazarus JV, Ratziu V, et al. "A multisociety Delphi consensus statement on new fatty liver disease nomenclature." Hepatology. 2023;78(6):1966-1986. | 6 primary references | 2026 |
| GlyNAC: Rebuilding Glutathione as You Age A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) An evidence-based guide to GlyNAC (glycine plus NAC): the glutathione-and-aging thesis, what the small trials show, the independent trial that did not replicate, the large doses involved, and how to think about it. Primary anchor: Sekhar RV, Patel SG, Guthikonda AP, et al. Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation. American Journal of Clinical Nutrition. 2011;94(3):847-853. | 6 primary references | 2026 |
| Growth Hormone Peptides, Headache, and Vision A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Endocrinology & Reproductive Health) Raised pressure around the brain is a recognized adverse effect of growth hormone. The peptides that raise your own growth hormone work through the same axis, and none of them come with the eye monitoring the drug requires. Primary anchor: Malozowski S, Tanner LA, Wysowski D, Fleming GA. "Growth Hormone, Insulin-Like Growth Factor I, and Benign Intracranial Hypertension." New England Journal of Medicine. 1993;329(9):665-666. | 6 primary references | 2026 |
| Healthy at the Jersey Shore A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Heat, jellyfish, greenhead flies, stomach bugs, and sun. A Philly doctor's summer guide for Ocean City, Cape May, LBI, the Wildwoods, and the rest of the Jersey Shore, from a practice licensed in New Jersey. Primary anchor: Centers for Disease Control and Prevention. "Heat-related Illnesses (NIOSH)." Accessed 2026. | 6 primary references | 2026 |
| Microplastics in Philadelphia: What to Do A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Geroscience & Healthspan Medicine) An evidence-based playbook for reducing microplastic exposure in Philadelphia households: the 5 changes that do most of the work, and how to read the headlines. Primary anchor: Marfella R, et al. Microplastics and Nanoplastics in Atheromas and Cardiovascular Events. New England Journal of Medicine. 2024;390(10):900-910. The landmark cohort tying carotid-plaque microplastic burden to cardiovascular events. | 6 primary references | 2026 |
| Plasmalogens and Brain Aging: What the Evidence Shows A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Plasmalogens are brain fats that fall with age and drop further in Alzheimer's. The biology is strong, the supplement evidence is early. A measured read from Fishtown Medicine in Philadelphia. Primary anchor: Goodenowe DB, Cook LL, Liu J, et al. "Peripheral ethanolamine plasmalogen deficiency: a logical causative factor in Alzheimer's disease and dementia." Journal of Lipid Research. 2007;48(11):2485-2498. | 6 primary references | 2026 |
| Preconception Planning: The 90-Day Runway A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Care Coordination & Preventive Protocols) A physician's preconception plan for both partners: the labs to run first, the nutrients most prenatals miss (choline), CoQ10 for egg and sperm quality, and why strength training and cardiovascular conditioning belong in the plan. Primary anchor: Gaskins AJ, Chavarro JE. "Diet and Fertility: A Review." American Journal of Obstetrics and Gynecology. 2018;218(4):379-389. | 6 primary references | 2026 |
| Red Light Therapy: Photosynthesis for Humans A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Learn how red light therapy (photobiomodulation) works at the mitochondrial level to boost energy, reduce inflammation, and accelerate recovery. Philadelphia... Primary anchor: Hamblin MR. Mechanisms and Mitochondrial Redox Signaling in Photobiomodulation. Photochem Photobiol. 2018. (The definitive review of the CCO mechanism). | 6 primary references | 2026 |
| Remnant Cholesterol: The Risk Hiding in Your Standard Panel A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Preventive Cardiology & Lipids) Remnant cholesterol is a causal heart risk you can calculate for free from a standard lipid panel, and it explains "normal LDL but still at risk." How to find it and what to do, from Fishtown Medicine in Philadelphia. Primary anchor: Varbo A, Benn M, Tybjærg-Hansen A, Jørgensen AB, Frikke-Schmidt R, Nordestgaard BG. "Remnant cholesterol as a causal risk factor for ischemic heart disease." Journal of the American College of Cardiology. 2013;61(4):427-436. | 6 primary references | 2026 |
| Severe Weather in Philadelphia: What to Do When the Alert Hits A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Geroscience & Healthspan Medicine) A Philadelphia doctor on the National Weather Service alerts that matter for your health, and the moves worth taking from heat advisory to flash flood warning. Primary anchor: Bouchama, A., & Knochel, J. P. (2002). Heat stroke. New England Journal of Medicine, 346(25), 1978-1988. | 6 primary references | 2026 |
| Should You Test for APOE4? What Knowing Your Risk Gene Means A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Geroscience & Healthspan Medicine) APOE4 is the strongest common gene tied to late-onset Alzheimer's, but it is a risk factor rather than a verdict. What the risk truly is, the insurance trap before you test, what you can do about it, and why status now affects treatment. Primary anchor: Fortea J, Pegueroles J, Alcolea D, et al. "APOE4 Homozygosity Represents a Distinct Genetic Form of Alzheimer's Disease." Nature Medicine. 2024;30(6):1284-1291. | 6 primary references | 2026 |
| Stage fright in a conservatory town A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Philadelphia runs on auditions, juries, orals, and the bar exam. What a physician here sees, what beta-blockers do and do not fix, and where to get assessed properly. Primary anchor: Brantigan CO, Brantigan TA, Joseph N. Effect of beta blockade and beta stimulation on stage fright. The American Journal of Medicine. 1982;72(1):88-94. | 6 primary references | 2026 |
| Taurine: What the Aging Research Does and Doesnt Show A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) An evidence-based guide to taurine: what the 2023 Science aging study found, what human trials show for blood pressure and the heart, and how to use it sensibly. Primary anchor: Singh P, Gollapalli K, Mangiola S, et al. Taurine deficiency as a driver of aging. Science. 2023. | 6 primary references | 2026 |
| The answers that make me say no A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Therapeutics & Pharmacology) The conditions, medicines, and situations that rule propranolol out or change the plan, written from the screening side, with the reason each one is on the list. Primary anchor: US Food and Drug Administration. Inderal (propranolol hydrochloride) prescribing information. FDA Access Data. | 6 primary references | 2026 |
| The antihistamine, and the question nobody asks about it A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Therapeutics & Pharmacology) Hydroxyzine sedates through the same pathway as older allergy medicines. What that costs in anticholinergic burden, why tolerance builds fast, and who should avoid it. Primary anchor: American Geriatrics Society. Beers Criteria for Potentially Inappropriate Medication Use in Older Adults. | 6 primary references | 2026 |
| The Centenarian Decathlon: Training for the Life You Want at 80 and 90 A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Geroscience & Healthspan Medicine) The centenarian decathlon is a list of physical tasks you want to be able to do late in life, trained for like an event. How to write yours, the physiology of backcasting, and how a physician builds it into care. Primary anchor: Attia P. Outlive: The Science and Art of Longevity. Harmony; 2023. The centenarian decathlon's origin. | 6 primary references | 2026 |
| The Cholesterol Test Thats Often Missing from Standard Panels A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Preventive Cardiology & Lipids) Why your 'normal' cholesterol might be misleading. Dr. Ash uses ApoB, Lp(a), and Cleerly AI to catch heart disease decades before a heart attack. Primary anchor: Sniderman AD, et al. "Apolipoprotein B Particles and Cardiovascular Disease: A Narrative Review." JAMA Cardiology. 2019. | 6 primary references | 2024 |
| The GLP-1 Strategy A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Metabolic Medicine & Bioenergetics) Why prescribing the shot is the easy part. Learn how we manage muscle preservation, protein intake, and the exit strategy for sustainable results. Primary anchor: Wilding JPH, et al. Once-Weekly Semaglutide in Adults with Overweight or Obesity. N Engl J Med. 2021;384(11):989-1002. The STEP 1 trial. | 6 primary references | 2026 |
| The Marginal Decade: Planning for the Last 10 Years of Your Life A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Geroscience & Healthspan Medicine) The marginal decade is the last 10 years of your life, and what you can do in it is decided 20 or 30 years earlier. How the exercise works, why it changes people, and how we build it into your care in Philadelphia and by telehealth. Primary anchor: Attia P. Outlive: The Science and Art of Longevity. Harmony; 2023. The origin of the marginal decade framing. | 6 primary references | 2026 |
| The most-prescribed sleep drug with the least evidence A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Therapeutics & Pharmacology) Low-dose trazodone is one of the most common sleep prescriptions in America. The sleep guideline recommends against it. Both of those are true. Primary anchor: Sateia MJ, Buysse DJ, Krystal AD, Neubauer DN, Heald JL. Clinical Practice Guideline for the Pharmacologic Treatment of Chronic Insomnia in Adults. Journal of Clinical Sleep Medicine. 2017;13(2):307-349. | 6 primary references | 2026 |
| The one that increases deep sleep, and the one with a tether A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Therapeutics & Pharmacology) Gabapentin does increase slow-wave sleep. It also carries a breathing warning, a withdrawal syndrome, and enough misuse potential to be scheduled in several states. Primary anchor: US Food and Drug Administration. FDA warns about serious breathing problems with seizure and nerve pain medicines gabapentin and pregabalin. Drug Safety Communication, December 2019. | 6 primary references | 2026 |
| The sleeping pills that carry a boxed warning A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Therapeutics & Pharmacology) Zolpidem, eszopiclone and zaleplon work, and they carry an FDA boxed warning for complex sleep behaviors. What that means, who should avoid them, and how they are prescribed here. Primary anchor: US Food and Drug Administration. FDA adds Boxed Warning for risk of serious injuries caused by sleepwalking with certain prescription insomnia medicines. Drug Safety Communication, April 2019. | 6 primary references | 2026 |
| Tired for Months, Labs 'Normal': The Workup That Found It A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) A 41-year-old with 8 months of fatigue and a "normal" checkup. The primary care workup that found the 2 causes her 12-minute visit missed, and what a fatigue evaluation should include. Primary anchor: Rosenthal TC, Majeroni BA, Pretorius R, Malik K. Fatigue: An Overview. Am Fam Physician. 2008;78(10):1173-1179. | 6 primary references | 2026 |
| Two ways to quiet a moment, and what each one costs A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Therapeutics & Pharmacology) Propranolol blocks the body's adrenaline response. A benzodiazepine sedates the brain. Side by side on speed, duration, side effects, dependence, and what each one does to a performance. Primary anchor: Brantigan CO, Brantigan TA, Joseph N. Effect of beta blockade and beta stimulation on stage fright. The American Journal of Medicine. 1982;72(1):88-94. | 6 primary references | 2026 |
| UV Index in Philadelphia Today: What to Do at Every Tier A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Geroscience & Healthspan Medicine) Today's live UV index for Philadelphia, plus what it means for you: burn time by skin type, when sunscreen matters most, and the vitamin D trade-off. Primary anchor: Whiteman, D. C., Whiteman, C. A., & Green, A. C. (2001). Childhood sun exposure as a risk factor for melanoma: a systematic review of epidemiologic studies. Cancer Causes & Control, 12(1), 69-82. | 6 primary references | 2026 |
| What Happens When You Stop a Statin A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Preventive Cardiology & Lipids) Heart attacks can cluster in the weeks after someone stops a statin, even a short gap. Why statins do more than lower cholesterol, what the rebound is, and the durable fix. Primary anchor: Heeschen C, Hamm CW, Laufs U, et al. "Withdrawal of statins increases event rates in patients with acute coronary syndromes." Circulation. 2002;105(12):1446-1452. | 6 primary references | 2026 |
| What Your Lab Results Mean A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Diagnostic Imaging & Biomarker Triage) What the flags, ranges, and units on a lab report mean, why normal is a starting point, and how Dr. Ash reads results against your history and trend. Primary anchor: Clinical and Laboratory Standards Institute. "Defining, Establishing, and Verifying Reference Intervals in the Clinical Laboratory; Approved Guideline." CLSI document EP28-A3c. 2010. (Reference intervals are conventionally the central 95% of values in a healthy reference population.) | 6 primary references | 2026 |
| When Low Iron Won't Resolve: The Hidden Cause A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Persistent low ferritin that never improves can point to autoimmune gastritis, a hidden cause of iron deficiency. What to test, and why it gets missed. Primary anchor: Kulnigg-Dabsch S. "Autoimmune gastritis." Wiener Medizinische Wochenschrift. 2016;166(13-14):424-430. | 6 primary references | 2026 |
| When to Order Imaging A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Diagnostic Imaging & Biomarker Triage) A Philadelphia internal medicine doctor on the framework for deciding when a scan is worth ordering, when it can do harm, and how to pick the right tool for the question. Primary anchor: Gulati, M., et al. (2021). 2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR Guideline for the Evaluation and Diagnosis of Chest Pain. Journal of the American College of Cardiology, 78(22), e187-e285. | 6 primary references | 2026 |
| When your body sabotages the moment you prepared for A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) Propranolol blocks the physical side of performance nerves and leaves the fear in place. What it does, who should not take it, and how strong the evidence is. Primary anchor: Brantigan CO, Brantigan TA, Joseph N. Effect of beta blockade and beta stimulation on stage fright. The American Journal of Medicine. 1982;72(1):88-94. | 6 primary references | 2026 |
| You Read Outlive. Here Is How It Becomes Your Medical Care. A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Geroscience & Healthspan Medicine) Peter Attia's Outlive changed how many people think about prevention. Turning the book into your own medical plan takes a physician, labs, and follow-through. Here is what that looks like in practice, in Philadelphia and by telehealth. Primary anchor: Attia P. Outlive: The Science and Art of Longevity. Harmony; 2023. | 6 primary references | 2026 |
| Your Calcium Score Is High. Now What? A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Preventive Cardiology & Lipids) A high coronary calcium score is information rather than a verdict. Dr. Ash explains what the Agatston score measures, the power of zero, and the workup - ApoB, Lp(a), blood pressure, and a Cleerly CCTA - that turns a scary number into a plan. Primary anchor: Detrano R, Guerci AD, Carr JJ, et al. "Coronary Calcium as a Predictor of Coronary Events in Four Racial or Ethnic Groups." New England Journal of Medicine. 2008. | 6 primary references | 2026 |
| Acne A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) Acne is a treatable medical condition rather than a hygiene problem. The drivers, the treatments with evidence, and the hormonal workup most quick visits skip. Primary anchor: Zaenglein AL, et al. "Guidelines of Care for the Management of Acne Vulgaris." J Am Acad Dermatol. 2016. | 5 primary references | 2026 |
| ADHD and Sleep A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Most adults with ADHD struggle with sleep, and it is not a willpower problem. The ADHD brain tends toward a delayed body clock, late melatonin, and a mind that will not switch off. How the two are connected, and how to rebuild sleep, from Fishtown Medicine in Philadelphia. Primary anchor: Hvolby A. Associations of sleep disturbance with ADHD: implications for treatment. Atten Defic Hyperact Disord. 2015;7(1):1-18. | 5 primary references | 2026 |
| ADHD in Women: Why It Gets Missed A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) ADHD in women is under-recognized because it often looks like anxiety, perfectionism, and exhaustion rather than hyperactivity, and because symptoms rise and fall with estrogen. A whole-system look at how adult ADHD shows up in women, from Fishtown Medicine in Philadelphia. Primary anchor: Quinn PO, Madhoo M. A review of attention-deficit/hyperactivity disorder in women and girls: uncovering this hidden diagnosis. Prim Care Companion CNS Disord. 2014;16(3):PCC.13r01596. | 5 primary references | 2026 |
| ADHD Look-Alikes: What Else Could It Be? A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Before you accept an ADHD diagnosis, it is worth ruling out the ordinary conditions that mimic it: thyroid disease, low iron, poor sleep and sleep apnea, anxiety, depression, B12 deficiency, blood sugar swings, and perimenopause. A physician's differential, from Fishtown Medicine in Philadelphia. Primary anchor: Faraone SV, et al. The World Federation of ADHD International Consensus Statement: 208 evidence-based conclusions about the disorder. Neurosci Biobehav Rev. 2021;128:789-818. | 5 primary references | 2026 |
| ADHD: A Detailed Guide to Diagnosis & Care A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) More than just stimulants. A whole-system approach to ADHD diagnosis, medication, and nervous system regulation in adults. Primary anchor: Faraone SV, et al. The World Federation of ADHD International Consensus Statement: 208 evidence-based conclusions about the disorder. Neurosci Biobehav Rev. 2021;128:789-818. | 5 primary references | 2026 |
| Adult Eczema That Won't Settle A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) Adult eczema that keeps flaring is often a whole-body inflammatory pattern that surfaces on the skin. The sleep, stress, and metabolic drivers worth checking, and the labs that find them. Primary anchor: Silverberg JI. "Comorbidities and the impact of atopic dermatitis." Annals of Allergy, Asthma & Immunology. 2019;123(2):144-151. | 5 primary references | 2026 |
| Anxiety & The Gut-Brain Axis A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Metabolic Medicine & Bioenergetics) Discover why your anxiety might be a microbial problem. Explore the Psychobiotic revolution and how the Vagus Nerve connects your gut to your brain. Primary anchor: Dinan TG, Cryan JF. "Psychobiotics: a novel class of psychotropic." Biological Psychiatry. 2013. | 5 primary references | 2024 |
| August in Philly: A Doctor's Guide to the Month A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) A Philadelphia doctor's guide to August: the hottest weeks, back-to-school colds, booking fall care early, and tropical rain riding up I-95. Primary anchor: Semenza, J. C., Rubin, C. H., Falter, K. H., et al. (1996). Heat-related deaths during the July 1995 heat wave in Chicago. New England Journal of Medicine, 335(2), 84-90. | 5 primary references | 2026 |
| Back Pain & Sciatica Doctor in Philadelphia: Stop Guessing, Start Healing A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) A detailed, osteopathic approach to back pain, sciatica, and spinal health in Fishtown. We rule out the scary stuff and treat the root cause. Primary anchor: Hoy D, et al. "The global burden of low back pain: estimates from the Global Burden of Disease 2010 study." Ann Rheum Dis. 2014. | 5 primary references | 2026 |
| Banned in the sports where they work A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Therapeutics & Pharmacology) Beta-blockers are prohibited under WADA class P1 in a defined set of sports. Which ones, when the ban applies, and how a therapeutic use exemption works. Primary anchor: World Anti-Doping Agency. The Prohibited List: P1 Beta-blockers. | 5 primary references | 2026 |
| Beyond Low T: The Complete Andropause Guide A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Endocrinology & Reproductive Health) Testosterone is not a solo act. Dr. Ash manages andropause with a focus on safety, fertility preservation, and cardiovascular health. A modern, systems-based approach. Primary anchor: Travison TG, et al. "A population-level decline in serum testosterone levels in American men." Journal of Clinical Endocrinology and Metabolism. 2007. | 5 primary references | 2026 |
| Beyond Statins: Other Ways to Lower Cholesterol and ApoB A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Preventive Cardiology & Lipids) Can't tolerate a statin, or need more lowering than one provides? Ezetimibe, bempedoic acid, PCSK9 inhibitors, and lifestyle all lower cardiovascular risk. The options compared, and how Fishtown Medicine uses them in Philadelphia. Primary anchor: Cannon CP, Blazing MA, Giugliano RP, et al. "Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes." New England Journal of Medicine. 2015;372(25):2387-2397. | 5 primary references | 2026 |
| Beyond the Basics: A Strategy for High Cholesterol A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Health Systems & Clinical Communication) Stop relying on 'LDL' alone. Learn why Fishtown Medicine focuses on ApoB and advanced lipid panels to prevent heart disease decades before it starts. Primary anchor: Sniderman AD, et al. Apolipoprotein B Particles and Cardiovascular Disease: A Narrative Review. JAMA Cardiol. 2019;4(12):1287-1295. | 5 primary references | 2026 |
| BHRT & Menopause 3.0: Protecting Brain and Bone A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Navigate perimenopause and menopause with confidence. We offer Bio-Identical Hormone Replacement Therapy (BHRT) aimed at symptom relief and long-term neuroprotection. Primary anchor: Manson JE, et al. "Menopausal hormone therapy and long-term all-cause and cause-specific mortality: The Women's Health Initiative randomized trials." JAMA. 2017. | 5 primary references | 2026 |
| Bioidentical Hormones & WHI Data A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Setting the record straight on hormone replacement therapy. See why the WHI study was misread and what bioidentical estrogen and progesterone really do. Primary anchor: Manson JE, et al. Menopausal hormone therapy and long-term all-cause and cause-specific mortality: the Women's Health Initiative randomized trials. JAMA. 2017. (Critical re-analysis of the WHI by age group.) | 5 primary references | 2026 |
| Biological Age Testing A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) You have two ages: chronological and biological. See why epigenetic methylation clocks are the gold standard for measuring how fast you are aging. Primary anchor: Horvath S, et al. DNA methylation GrimAge strongly predicts lifespan and healthspan. Aging. 2019. | 5 primary references | 2026 |
| Bloated After Every Meal? Here's Why. A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) Look 6 months pregnant after a meal? It's likely not 'just IBS.' We treat the root cause of bloating, from SIBO to low stomach acid. Primary anchor: Pimentel M, et al. "ACG Clinical Guideline: Small Intestinal Bacterial Overgrowth." Am J Gastroenterol. 2020. | 5 primary references | 2024 |
| Bone Health: Quality over Quantity A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Geroscience & Healthspan Medicine) A hip fracture in your 80s can be lethal. Discover why standard DEXA scans miss bone quality issues and how much-needed resistance training builds structural... Primary anchor: Silva BC, et al. "Trabecular Bone Score: A Noninvasive Analytical Method Based on the DXA Image." J Bone Miner Res. 2014. | 5 primary references | 2024 |
| Brain Fog Isnt Aging. Its Metabolic. A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) Experiencing brain fog or memory lapses? It might not be just aging. We provide deep-dive metabolic evaluations to optimize cognitive performance for professionals. Primary anchor: Livingston G, et al. "Dementia prevention, intervention, and care: 2024 report of the Lancet Commission." The Lancet. 2024. | 5 primary references | 2026 |
| Burnout Is Not a Badge of Honor A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Exercise Physiology & Cardiorespiratory Fitness) Your drive should not cost you your health. We help Philadelphia executives and founders build a biological buffer against burnout. Primary anchor: McEwen BS. Allostasis and allostatic load: implications for neuropsychopharmacology. Neuropsychopharmacology. 2000;22(2):108-124. | 5 primary references | 2024 |
| Calcium: The Double-Edged Sword A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Why taking Calcium without K2 can lead to misdirected calcification. A clinical perspective on protecting arterial health while building bone density. Primary anchor: Bolland, M. J., et al. (2010). "Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis." BMJ, 341, c3691. | 5 primary references | 2024 |
| Can You Test Your Mitochondria? A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Diagnostic Imaging & Biomarker Triage) Mitochondrial testing is sold to tired people as a way to measure their energy at the source. What these panels can and cannot tell you, and what the evidence supports, from Fishtown Medicine in Philadelphia. Primary anchor: Gorman GS, Chinnery PF, DiMauro S, et al. "Mitochondrial diseases." Nature Reviews Disease Primers. 2016;2:16080. | 5 primary references | 2026 |
| Catching It Early: Advanced Screening A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Geroscience & Healthspan Medicine) Early detection is the best cure. Dr. Ash integrates Liquid Biopsy (Galleri) and whole-body MRI (MRI-DWI) into a detailed cancer defense strategy. Primary anchor: Klein EA, et al. "Clinical validation of a targeted methylation-based multi-cancer early detection test using an independent validation set." Annals of Oncology. 2021. | 5 primary references | 2024 |
| Choosing a Longevity Physician A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Not all 'anti-aging' clinics are the same. Learn how to tell a med-spa apart from a true Medicine 3.0 practice in Philadelphia. Primary anchor: Attia P. Outlive: The Science and Art of Longevity. Harmony; 2023. The core text on Medicine 3.0 and the move from reactive to proactive care. | 5 primary references | 2024 |
| Choosing Mental Health Apps: A Clinical Guide A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Health Systems & Clinical Communication) From PTSD Coach to CBT-i, learn which mental health apps are evidence-based and how to integrate them into your treatment plan for better sleep and resilience. Primary anchor: Ben-Zeev D, et al. Mobile Behavioral Sensing for Outpatients and Inpatients With Schizophrenia. Psychiatr Serv. 2016;67(5):558-561. | 5 primary references | 2026 |
| Clinical Guide Library A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Therapeutics & Pharmacology) Browse evidence-based clinical guides on supplements, hormones, and treatment protocols. Each guide covers dosing, safety, and when it helps. Primary anchor: Mortensen SA, et al. "The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure." JACC Heart Failure. 2014;2(6):641-649. | 5 primary references | 2026 |
| Collagen: Building Structural Resilience A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Evidence-based guide to Collagen Peptides. Strengthen tendons, improve skin elasticity, and support joint recovery for active Philadelphians. Primary anchor: Zdzieblik D, et al. Collagen peptide supplementation in combination with resistance training improves body composition and increases muscle strength in elderly sarcopenic men: a randomised controlled trial. Br J Nutr. 2015. | 5 primary references | 2026 |
| Constant Congestion? The Real Cause. A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) Tired of sinus infections and constant congestion? It might be your rowhome, your gut, or your immune system. We identify the root cause of respiratory inflammation. Primary anchor: Maintz L, Novak N. "Histamine and histamine intolerance." American Journal of Clinical Nutrition. 2007. | 5 primary references | 2026 |
| CoQ10: Sparking Mitochondrial Bioenergetics A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Why your cells need CoQ10 to make ATP. Learn how this mitochondrial enzyme powers your heart, why statins deplete it, and ubiquinol vs ubiquinone explained. Primary anchor: Mortensen SA, et al. The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO: a randomized double-blind trial. JACC Heart Fail. 2014. | 5 primary references | 2026 |
| Creatine: The Brains Backup Battery A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Exercise Physiology & Cardiorespiratory Fitness) Safe, cheap, and well-studied. Learn why creatine monohydrate is one of the most underrated brain supplements for cognitive fatigue and resilience. Primary anchor: Rae C, et al. Oral creatine monohydrate supplementation improves brain performance: a double-blind, placebo-controlled, cross-over trial. Proc Biol Sci. 2003;270(1529):2147-2150. | 5 primary references | 2024 |
| Curcumin: Targeting the Inflammatory Fire A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Evidence-based guide to Curcumin. Learn why 'powder' doesn't work, the importance of fat/piperine for absorption, and safety for blood thinners. Primary anchor: Hewlings SJ, et al. Curcumin: A Review of Its Effects on Human Health. Foods. 2017. | 5 primary references | 2026 |
| Cyclospora: Why That Diarrhea Won't Quit, and What Clears It A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) Cyclospora causes weeks of relapsing diarrhea that routine tests miss. How it spreads, the specific test to ask for, and the antibiotic that clears it. Primary anchor: Centers for Disease Control and Prevention. Domestically Acquired Cyclosporiasis Cases in Multiple U.S. States, 2026. CDC Health Alert Network (HAN) Health Advisory. https://www.cdc.gov/han/php/notices/han00531.html | 5 primary references | 2026 |
| Daily Headaches Arent Normal. A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) Stop managing the pain. Start finding the cause. Dr. Ash offers a detailed, detective-style evaluation. In our practice, we see three common drivers of chronic headaches. Primary anchor: Goadsby PJ, et al. "CGRP-targeted therapies for migraine prevention." Nature Reviews Neurology. 2020. | 5 primary references | 2026 |
| DHEA: The Upstream Hormone A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) A clinical guide to DHEA supplementation. What it does, who might benefit, and the risks of unsupervised use. Primary anchor: Rutkowski K, et al. Dehydroepiandrosterone (DHEA): hypes and hopes. Drugs. 2014. | 5 primary references | 2026 |
| Dizziness and a Racing Heart When You Stand: When to Think About POTS A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) A 27-year-old with 6 months of lightheadedness, a pounding heart in the shower, and normal urgent-care tests. The 10-minute stand test that found her POTS, and the plan that got her life back. Primary anchor: Raj SR, Guzman JC, Harvey P, et al. Canadian Cardiovascular Society Position Statement on Postural Orthostatic Tachycardia Syndrome (POTS) and Related Disorders of Chronic Orthostatic Intolerance. Can J Cardiol. 2020;36(3):357-372. | 5 primary references | 2026 |
| Dizzy Spells? What Your Bodys Telling You. A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) Tired of being told your dizziness is 'just anxiety'? We investigate the autonomic and metabolic root causes of lightheadedness, from POTS to iron deficiency. Primary anchor: Sheldon RS, et al. "2015 heart rhythm society expert consensus statement on the diagnosis and treatment of POTS." Heart Rhythm. 2015. | 5 primary references | 2026 |
| Droopy Eyelid and Tired Eyes: Illness Fatigue or Something Else A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) Eyelids that feel heavy and vision that blurs by evening usually means an exhausted body. Two bedside tests and one question about double vision separate ordinary fatigue from a neurologic cause. Primary anchor: Sethi KD, Rivner MH, Swift TR. "Ice Pack Test for Myasthenia Gravis." Neurology. 1987;37(8):1383-1385. | 5 primary references | 2026 |
| Early Cancer Detection A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Go beyond standard cancer screening. A Philadelphia primary care practice using liquid biopsies and whole-body MRI to find disease earlier. Primary anchor: Klein EA, et al. Clinical validation of a targeted methylation-based multi-cancer early detection test using circulating cell-free DNA (CCGA). Annals of Oncology. 2021. | 5 primary references | 2026 |
| Environment: The Silent Third Party A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) How the physical world shapes your biology hour by hour: air, water, light, the house you live in, the city around it, and the digital inputs you bring inside. Primary anchor: Pope CA, et al. "Lung Cancer, Cardiopulmonary Mortality, and Long-term Exposure to Fine Particulate Air Pollution." JAMA. 2002. | 5 primary references | 2026 |
| Erectile Dysfunction in Men A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) ED is treatable, common, and often the earliest warning sign of vascular disease. The workup, the medications that work, and when to escalate. Primary anchor: Goldstein I, et al. "Oral Sildenafil in the Treatment of Erectile Dysfunction." N Engl J Med. 1998. | 5 primary references | 2026 |
| Eyelash Health A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) Thinning lashes usually point to a cause you can find and fix. The local and systemic reasons behind them, and the one FDA-approved treatment that regrows them. Primary anchor: Smith S, Fagien S, Whitcup SM, et al. "Eyelash growth in subjects treated with bimatoprost: a multicenter, randomized, double-masked, vehicle-controlled, parallel-group study." Journal of the American Academy of Dermatology. 2012;66(5):801-806. | 5 primary references | 2026 |
| Fasting Protocols: The Goldilocks Zone A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Metabolic Medicine & Bioenergetics) Fasting is a tool you can learn to use with care. Here is how to run time-restricted eating, 24-hour fasts, and longer protocols safely while protecting your muscle. Primary anchor: de Cabo R, Mattson MP. Effects of Intermittent Fasting on Health, Aging, and Disease. N Engl J Med. 2019;381(26):2541-2551. The gold-standard review. | 5 primary references | 2024 |
| Feeling Sick After a Flu Shot? A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) Is it the shot or just bad timing? Learn the science of recency bias, the 14-day immunity lag, and how to support your immune system through Philly winter. Primary anchor: Centers for Disease Control and Prevention. "Vaccine Effectiveness: How Well Do Flu Vaccines Work?" | 5 primary references | 2024 |
| Finding a Cancer Clinical Trial: What I Want You to Know A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Geroscience & Healthspan Medicine) How to find a cancer clinical trial that fits your diagnosis, what joining costs, the free ACS matching service, and where trials run near Philadelphia. Primary anchor: American Cancer Society. ACS ACTS: Finding the Right Clinical Trial for You. cancer.org/cancer/making-treatment-decisions/clinical-trials/acs-acts.html | 5 primary references | 2026 |
| Finerenone (Kerendia): The Kidney-and-Heart Drug for Diabetes A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Metabolic Medicine & Bioenergetics) Finerenone (Kerendia) protects the kidneys and heart in diabetic kidney disease, and now in heart failure. How it works, what the trials showed, the high-potassium caution, and how it fits with SGLT2 inhibitors. Primary anchor: Bakris GL, Agarwal R, Anker SD, et al. "Effect of Finerenone on Chronic Kidney Disease Outcomes in Type 2 Diabetes." New England Journal of Medicine. 2020;383(23):2219-2229. | 5 primary references | 2026 |
| Fix Your Gut. Sharpen Your Mind. A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Exercise Physiology & Cardiorespiratory Fitness) Your gut is your second brain. We help driven Philadelphians tune their microbiome for cognitive clarity, immunity, and metabolic efficiency. Primary anchor: Cryan JF, et al. The Microbiota-Gut-Brain Axis. Physiol Rev. 2019;99(4):1877-2013. | 5 primary references | 2024 |
| Genetics: The Dial You Can Turn A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) How we use genetic data at Fishtown Medicine. Which tests change the plan, which ones are expensive curiosity, and why your DNA shapes your risk rather than determining it. Primary anchor: Khera AV, et al. "Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations." Nature Genetics. 2018. | 5 primary references | 2026 |
| Ginkgo: Neuroprotection & Blood Flow A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Evidence-based guide to Ginkgo Biloba. Learn about the '24/6' standardization, benefits for Raynaud's/cold hands, and safety warnings for blood thinners. Primary anchor: Tan MS, et al. Efficacy and adverse effects of ginkgo biloba for cognitive impairment and dementia: a systematic review and meta-analysis. J Alzheimers Dis. 2015. | 5 primary references | 2026 |
| Glycine: The Secret to Deep Sleep & Detox A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Evidence-based guide to Glycine supplementation in Philadelphia. Learn how 3g of Glycine can improve sleep quality, support joint health, and stabilize mood. Primary anchor: Kawai N, et al. The sleep-promoting and hypothermic effects of glycine are mediated by NMDA receptors in the suprachiasmatic nucleus. Neuropsychopharmacology. 2015. | 5 primary references | 2026 |
| Gray Hair A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) Graying is mostly genetic; stress, mitochondria, and a few nutrient deficiencies play a part. What speeds it up, what can reverse it, and which products are hype. Primary anchor: Wood JM, Decker H, Hartmann H, et al. "Senile hair graying: H2O2-mediated oxidative stress affects human hair color by blunting methionine sulfoxide repair." FASEB Journal. 2009;23(7):2065-2075. | 5 primary references | 2026 |
| Green Tea: Metabolic Clarity in a Cup A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Evidence-based guide to Green Tea Extract (EGCG). Learn about 'calm focus', metabolic support, and how to avoid liver stress. Primary anchor: Chacko SM, et al. Beneficial effects of green tea: a literature review. Chin Med. 2010. | 5 primary references | 2026 |
| Grip Strength: The Check Engine Light for Longevity A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Exercise Physiology & Cardiorespiratory Fitness) Strong hands, longer life. Grip strength is a powerful proxy for muscle health, neuromuscular integrity, and mortality risk. Here is how to test it. Primary anchor: Leong DP, et al. Prognostic value of grip strength: findings from the Prospective Urban Rural Epidemiology (PURE) study. Lancet. 2015;386(9990):266-273. | 5 primary references | 2026 |
| Hair Loss for Men A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) Male pattern hair loss is treatable. Finasteride, minoxidil, the labs that rule out other causes, and the timing question most men get wrong. Primary anchor: Kaufman KD, et al. "Finasteride in the Treatment of Men With Androgenetic Alopecia." J Am Acad Dermatol. 1998. | 5 primary references | 2026 |
| Hair Loss for Women A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) Women's hair loss is rarely a single cause - ferritin, thyroid, perimenopause, PCOS, postpartum, and pattern loss overlap. The workup and treatments with evidence. Primary anchor: Sinclair R. "Female Pattern Hair Loss: A Pilot Study Investigating Combination Therapy with Low-Dose Oral Minoxidil and Spironolactone." Int J Dermatol. 2018. | 5 primary references | 2026 |
| Hand Hygiene and Your Microbiome A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Health Systems & Clinical Communication) Is hand sanitizer better than soap? Learn why Fishtown Medicine recommends soap and water to protect your skin barrier and immune resilience. Primary anchor: Larson EL, et al. Effect of antibacterial home cleaning and handwashing products on infectious disease symptoms: a randomized, double-blind trial. Ann Intern Med. 2004;140(5):321-329. | 5 primary references | 2026 |
| Healthy Skin Aging A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Geroscience & Healthspan Medicine) Most aging skin comes from the sun rather than the calendar. Sunscreen, retinoids, glucose control - the interventions with the best evidence - and the hype worth ignoring. Primary anchor: Hughes MCB, et al. "Sunscreen and Prevention of Skin Aging: A Randomized Trial." Ann Intern Med. 2013. | 5 primary references | 2026 |
| Heart Disease in Women: Different, and Often Missed A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Preventive Cardiology & Lipids) Cardiovascular disease is the leading killer of women, yet under-recognized. The truth about women's heart symptoms, the risk factors unique to women, the menopause window, and why women are undertreated. Primary anchor: Mehta LS, et al. "Acute Myocardial Infarction in Women: A Scientific Statement From the American Heart Association." Circulation. 2016;133(9):916-947. | 5 primary references | 2026 |
| Heavy Metal Detox: The Science A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Therapeutics & Pharmacology) Bioaccumulation is real, but most "detox teas" are not. Learn how to safely test for and reduce heavy metals using sauna, binders, and (rarely) chelation. Primary anchor: Genuis SJ, et al. Blood, urine, and sweat (BUS) study: monitoring and elimination of bioaccumulated toxic elements. Arch Environ Contam Toxicol. 2011;61(2):344-357. | 5 primary references | 2024 |
| Heavy Periods and Anemia: Breaking the Vicious Cycle A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Heavy periods cause low iron, and low iron causes heavier periods. Here is how we break the loop using non-hormonal options and root-cause testing. Primary anchor: Lukes AS, et al. "Tranexamic acid treatment for heavy menstrual bleeding: a randomized controlled trial." Obstetrics and Gynecology. 2010;116(4):865-875. | 5 primary references | 2026 |
| High Dose Vitamin C: The Pro-Oxidant Switch A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) At low doses Vitamin C is an antioxidant. At very high IV doses it changes mechanism entirely. See the science of pharmacologic ascorbate. Primary anchor: Chen Q, Levine M, et al. Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice. Proc Natl Acad Sci U S A. 2008. | 5 primary references | 2026 |
| How Long Is the Average Doctor's Visit? A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Health Systems & Clinical Communication) The average primary care visit is about 18 minutes, and it has barely moved in 30 years. Why it feels shorter, what the paperwork has to do with it, and a model built around time, from Fishtown Medicine in Philadelphia. Primary anchor: Neprash HT, Everhart A, McCabe D, Smith LB, Rozenshtein B, Golberstein E. "Measuring primary care exam length using electronic health record data." Medical Care. 2021;59(1):62-66. | 5 primary references | 2026 |
| How much, how early, how long A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Therapeutics & Pharmacology) The three questions people ask together. Dose ranges for situational use, when to take it, how long the effect holds, and why the first dose belongs at home. Primary anchor: US Food and Drug Administration. Inderal (propranolol hydrochloride) prescribing information, clinical pharmacology. FDA Access Data. | 5 primary references | 2026 |
| How to Check Your Peak Flow and What the Numbers Mean A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Diagnostic Imaging & Biomarker Triage) How to check your peak flow, find your personal best baseline, read the green, yellow, and red airway zones, and know when to seek emergency care. Primary anchor: National Asthma Education and Prevention Program. Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma (EPR-3). National Heart, Lung, and Blood Institute; 2007. NIH Publication No. 07-4051. | 5 primary references | 2026 |
| HSA/FSA Longevity Playbook A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Geroscience & Healthspan Medicine) Learn how to legally use your pre-tax HSA and FSA dollars to fund your longevity medicine, supplements, and gym memberships. Primary anchor: Internal Revenue Service. "Publication 502: Medical and Dental Expenses." | 5 primary references | 2024 |
| Hyperbaric Oxygen & Brain Repair A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Can high-pressure oxygen wake up sleeping neurons? See the science of HBOT for stroke recovery, traumatic brain injury, and brain fog. Primary anchor: Efrati S, et al. Hyperbaric oxygen induces late neuroplasticity in post-stroke patients: a randomized, prospective trial. PLoS One. 2013. | 5 primary references | 2026 |
| IBS & SIBO: The Root Cause A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Metabolic Medicine & Bioenergetics) Bloated after every meal? Up to 60% of IBS cases may be SIBO. Learn how we test, treat, and prevent recurrence. Primary anchor: Lembo A, Pimentel M, et al. Repeat treatment with rifaximin is safe and effective in patients with diarrhea-predominant irritable bowel syndrome. Gastroenterology. 2016;151(6):1113-1121. The TARGET 3 trial. | 5 primary references | 2024 |
| Immune Resilience: Rebuilding Your Body's Defense A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Health Systems & Clinical Communication) Getting sick more often? Learn about 'Immunity Debt' and the 6 actionable steps Fishtown Medicine uses to retrain and rebuild your immune system naturally. Primary anchor: Cohen S, et al. Sleep Habits and Susceptibility to the Common Cold. Arch Intern Med. 2009;169(1):62-67. | 5 primary references | 2026 |
| Inclisiran (Leqvio): The Twice-a-Year Cholesterol Injection A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Preventive Cardiology & Lipids) Inclisiran (Leqvio) is a twice-a-year injection that lowers LDL cholesterol by about half. How the siRNA works, how it compares to statins and PCSK9 inhibitors, and the caveat that its heart-attack prevention is still being tested. Primary anchor: Ray KK, Wright RS, Kallend D, et al. "Two Phase 3 Trials of Inclisiran in Patients with Elevated LDL Cholesterol." New England Journal of Medicine. 2020;382(16):1507-1519. | 5 primary references | 2026 |
| Inflammaging: The Chronic Inflammation Behind Aging A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Geroscience & Healthspan Medicine) Chronic, low-grade inflammation, or inflammaging, is a root driver of heart disease, diabetes, dementia, and frailty. What causes it, how to measure it, and how Fishtown Medicine helps lower it in Philadelphia. Primary anchor: Franceschi C, Bonafè M, Valensin S, et al. "Inflamm-aging: An evolutionary perspective on immunosenescence." Annals of the New York Academy of Sciences. 2000;908:244-254. | 5 primary references | 2026 |
| Integrative Cancer Care A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Therapeutics & Pharmacology) Going beyond the standard of care. Learn how Medicine 3.0 uses metabolic therapies and fasting alongside oncology to support patients through treatment. Primary anchor: Vernieri C, Longo VD, et al. Cyclic Fasting-Mimicking Diet in Cancer Treatment: Preclinical and Clinical Evidence. Cell Metab. 2024. | 5 primary references | 2024 |
| Iron Bisglycinate: High Absorption, No Gut Pain A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Evidence-based guide to Ferrous Bisglycinate (Iron) supplementation in Philadelphia. Learn why this gentle form of iron is superior for energy, fatigue, and recovery. Primary anchor: Milman N, et al. Ferrous bisglycinate 25 mg iron is as effective as ferrous sulfate 50 mg iron in the prophylaxis of iron deficiency and anemia during pregnancy in a randomized placebo-controlled trial. J Perinat Med. 2014. | 5 primary references | 2026 |
| Is Coffee Medicine? The Definitive Guide to Longevity. A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Geroscience & Healthspan Medicine) Discover the evidence-based health benefits of coffee. From reducing Type 2 diabetes risk to neuroprotection, learn the healthiest way to brew with Dr. Ash. Primary anchor: Grosso G, et al. "Coffee, Caffeine, and Health Outcomes: An Umbrella Review." Annual Review of Nutrition. 2017. | 5 primary references | 2026 |
| Is it anxiety or something else? A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) Anxiety isn't always 'in your head.' Learn how Fishtown Medicine investigates the hormonal and metabolic drivers of panic, racing heart, and overwhelm. Primary anchor: Bystritsky A, et al. "Current diagnosis and treatment of anxiety disorders." Pharm Ther. 2013. | 5 primary references | 2026 |
| Is Whole Genome Sequencing Worth It? A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Geroscience & Healthspan Medicine) Consumer whole genome tests promise thousands of health insights from one cheek swab. A Philadelphia physician on what your genome can change about your care, and what it cannot. Primary anchor: Khera AV, Chaffin M, Aragam KG, et al. Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations. Nature Genetics. 2018;50(9):1219-1224. | 5 primary references | 2026 |
| IV Vitamin Therapy A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Is IV hydration and nutrient therapy worth the hype? See the science of bioavailability and when high-dose IVs make clinical sense. Primary anchor: Gaby AR. Intravenous nutrient therapy: the Myers' cocktail. Altern Med Rev. 2002. | 5 primary references | 2026 |
| January in Philly: A Doctor's Guide to the Month A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) A Philadelphia doctor's guide to January: baseline labs worth measuring, vitamin D and mood in the dark weeks, safe snow shoveling, and a habit that lasts. Primary anchor: Franklin, B. A., Hogan, P., Bonzheim, K., et al. (1995). Cardiac demands of heavy snow shoveling. JAMA, 273(11), 880-882. | 5 primary references | 2026 |
| Keeping Your CDL: What to Work On Before the DOT Physical A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Internal Medicine & Prevention) What costs commercial drivers a 2-year medical card, how far ahead to start fixing it, and how care follows you across state lines on a long run. Primary anchor: Federal Motor Carrier Safety Administration. Medical Examiner Handbook and 49 CFR 391.41, Physical Qualifications for Drivers. | 5 primary references | 2026 |
| Kidney Function for Longevity: The Overlooked Organ A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Diagnostic Imaging & Biomarker Triage) The standard kidney test can mislead muscular people and creatine users. Cystatin C is a better cross-check, urine albumin catches damage early, and kidney health is a quiet driver of longevity and heart risk. Primary anchor: Kreider RB, Kalman DS, Antonio J, et al. "International Society of Sports Nutrition Position Stand: Safety and Efficacy of Creatine Supplementation in Exercise, Sport, and Medicine." Journal of the International Society of Sports Nutrition. 2017;14:18. | 5 primary references | 2026 |
| Leaky Gut: The Science of Permeability A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Metabolic Medicine & Bioenergetics) Pseudoscience or real biology? Learn the science of zonulin and how intestinal permeability drives autoimmune disease and chronic inflammation. Primary anchor: Fasano A. Zonulin and its regulation of intestinal barrier function: the biological door to inflammation, autoimmunity, and cancer. Physiol Rev. 2011;91(1):151-175. | 5 primary references | 2024 |
| Losing Your Hair? Genetics Is Rarely the Whole Story. A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) Struggling with thinning or shedding? We don't just guess. Get a deep-dive metabolic evaluation to identify the root cause of hair loss in Philadelphia. Primary anchor: Almohanna HM, et al. "The role of vitamins and minerals in hair loss." Dermatology and Therapy. 2019. | 5 primary references | 2026 |
| Low Blood Sugar and Reactive Hypoglycemia A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) Shakiness, 'hanger,' or panic attacks after meals? Learn how reactive hypoglycemia causes blood sugar crashes and how we build metabolic stability. Primary anchor: Galati SL, Rayfield EJ. "Reactive hypoglycemia." Endocrinology and Metabolism Clinics of North America. 1999. | 5 primary references | 2026 |
| Lump in Your Throat When You Eat? Globus, Reflux, and What to Check A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) A lump-in-throat feeling with fullness and belching after meals has a short list of causes. How we work up globus in Philadelphia, and what helps now. Primary anchor: Katz PO, Dunbar KB, Schnoll-Sussman FH, et al. ACG Clinical Guideline for the Diagnosis and Management of Gastroesophageal Reflux Disease. American Journal of Gastroenterology. 2022;117(1):27-56. | 5 primary references | 2026 |
| Magnesium: The Invisible Deficiency A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Therapeutics & Pharmacology) Why standard magnesium tests miss most deficiencies and how to choose the right form for sleep, brain fog, and anxiety. Primary anchor: Slutsky I, Liu G, et al. Enhancement of learning and memory by elevating brain magnesium. Neuron. 2010;65(2):165-177. | 5 primary references | 2024 |
| March in Philly: A Doctor's Guide to the Month A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) A Philadelphia doctor's guide to March: getting ahead of tree pollen before it peaks, easing through the clock change, and rebuilding movement after a long rowhome winter. Primary anchor: Janszky, I., & Ljung, R. (2008). Shifts to and from daylight saving time and incidence of myocardial infarction. New England Journal of Medicine, 359(18), 1966-1968. | 5 primary references | 2026 |
| May in Philly: A Doctor's Guide to the Month A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) A Philadelphia doctor's guide to May: the skin check to do before peak sun, how to pick a sunscreen you will re-apply, and why muscle earns 2 sessions a week. Primary anchor: Green, A. C., Williams, G. M., Logan, V., & Strutton, G. M. (2011). Reduced melanoma after regular sunscreen use: randomized trial follow-up. Journal of Clinical Oncology, 29(3), 257-263. | 5 primary references | 2026 |
| Metabolic Flexibility: The Holy Grail A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Metabolic Medicine & Bioenergetics) Weight is a lagging indicator. Insulin is a leading indicator. We use fasting insulin, CGMs, and DEXA scans to find and fix metabolic dysfunction. Primary anchor: Reaven GM. Banting lecture 1988. Role of insulin resistance in human disease. Diabetes. 1988;37(12):1595-1607. The foundational paper. | 5 primary references | 2024 |
| Metabolic Health: Why We Go Beyond A1C A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Health Systems & Clinical Communication) A 'normal' A1C isn't the whole story. Learn why Fishtown Medicine tracks fasting insulin, HOMA-IR, and glycemic variability to catch metabolic changes early. Primary anchor: Reaven GM. Insulin Resistance: The Link Between Obesity and Cardiovascular Disease. Med Clin North Am. 2011;95(5):875-892. | 5 primary references | 2026 |
| Metabolic Stall? Optimize Your Biology. A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) Stuck despite eating well and training hard - that is metabolic adaptation, not willpower. We help you signal safety to your body so it can use fuel properly. Primary anchor: Maclean PS, et al. "Biology's response to dieting: the impetus for weight regain." American Journal of Physiology - Regulatory, Integrative and Comparative Physiology. 2011. | 5 primary references | 2026 |
| Metabolism: Beyond the Scale A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Exercise Physiology & Cardiorespiratory Fitness) A nuance-first approach to metabolic health and GLP-1s. We focus on metabolic integrity and body composition, not just numbers on a scale. Primary anchor: Wilding JPH, et al. Once-Weekly Semaglutide in Adults with Overweight or Obesity. N Engl J Med. 2021;384(11):989-1002. | 5 primary references | 2024 |
| Metabolism: Getting Your Engine Working Right A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Metabolic Medicine & Bioenergetics) A grounded clinical approach to metabolic health and GLP-1s. We focus on biological restoration and body composition, fixing the engine first. Primary anchor: Wilding JPH, et al. Once-Weekly Semaglutide in Adults with Overweight or Obesity. N Engl J Med. 2021;384(11):989-1002. | 5 primary references | 2024 |
| Metformin for Longevity: The Anti-Aging Drug? A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Is metformin a magic pill for aging? See why we do not prescribe it to every patient, particularly athletes, and how we manage the risks. Primary anchor: Barzilai N, et al. Metformin as a tool to target aging. Cell Metab. 2016;23(6):1060-1065. | 5 primary references | 2026 |
| Migraine vs. Serious: When to Worry About a Headache A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) Is it just a migraine or something more? Learn the SNOOP checklist for headache safety and when you should seek urgent evaluation for head pain. Primary anchor: Dodick DW. "Pearls: headache." Seminars in Neurology. 2010 (SNOOP framework). | 5 primary references | 2026 |
| Mindfulness as a Biological Tool A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Therapeutics & Pharmacology) It is not "woo-woo." Learn the neuroscience of how mindfulness lowers cortisol, calms the amygdala, and reduces inflammation. Primary anchor: Kabat-Zinn J. Full Catastrophe Living. Bantam Dell, 1990. Foundational text on Mindfulness-Based Stress Reduction. | 5 primary references | 2024 |
| NAD+ vs. AG1: Separating the Science from the Hype A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) We dissect NAD+ boosters and greens powders to see what works for longevity. A clinical review from Dr. Ash. Primary anchor: Conze D, et al. Safety and metabolism of long-term administration of NIAGEN (nicotinamide riboside chloride) in a randomized, double-blind, placebo-controlled clinical trial of healthy overweight adults. Sci Rep. 2019;9(1):9772. | 5 primary references | 2026 |
| Nausea and Vomiting: What to Do and When to Worry A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) Experiencing nausea? Follow this clinical guide to manage symptoms at home, identify red flags, and understand how Fishtown Medicine helps. Primary anchor: Freedman SB, et al. Effect of Dilute Apple Juice and Preferred Fluids vs Electrolyte Maintenance Solution on Treatment Failure Among Children With Mild Gastroenteritis: A Randomized Clinical Trial. JAMA. 2016;315(18):1966-1974. | 5 primary references | 2026 |
| Negative Allergy Tests but Still Reacting? Why the Results Can Miss the Cause A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) Allergy panels and skin tests came back negative, but you still react to food, seasons, and scents? What a negative test rules in, and what it misses. Primary anchor: Maintz L, Novak N. Histamine and histamine intolerance. American Journal of Clinical Nutrition. 2007;85(5):1185-1196. | 5 primary references | 2026 |
| Nervous System Regulation: Healing from Stress A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Health Systems & Clinical Communication) Stuck in fight-or-flight? Learn evidence-based somatic tools to regulate your nervous system, lower your stress response, and help your body heal from trauma. Primary anchor: Porges SW. The Polyvagal Theory: New Insights into Adaptive Reactions of the Autonomic Nervous System. Cleve Clin J Med. 2009;76(Suppl 2):S86-S90. | 5 primary references | 2026 |
| Neuromodulation for Migraine A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Neuromodulation treats migraine without drugs by delivering gentle electrical stimulation to the trigeminal nerve, easing an attack and, used daily, reducing how often attacks come. How external trigeminal nerve stimulation (e-TNS) works, what the trials show, and where it fits in a whole-person migraine plan, from Fishtown Medicine in Philadelphia. Primary anchor: Headache Classification Committee of the International Headache Society (IHS). The International Classification of Headache Disorders, 3rd edition (ICHD-3). Cephalalgia. 2018;38(1):1-211. | 5 primary references | 2026 |
| Not addictive, and still not a pill to stop abruptly A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Therapeutics & Pharmacology) Propranolol causes no euphoria and no dependence, and daily use produces a physiological rebound on abrupt stopping. Why those are different things. Primary anchor: US Food and Drug Administration. Inderal (propranolol hydrochloride) prescribing information, warnings on abrupt cessation. FDA Access Data. | 5 primary references | 2026 |
| Oral Health & Longevity A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Geroscience & Healthspan Medicine) Why your mouth is the gateway to systemic health. Discover the heart-mouth connection, why mouthwash might be raising your blood pressure, and probiotic dent... Primary anchor: Kapil V, et al. "Physiological role for nitrate-reducing oral bacteria in blood pressure control." Free Radical Biology and Medicine. 2013. | 5 primary references | 2024 |
| Ozempic vs. Metformin: Which Strategy Wins? A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Metabolic Medicine & Bioenergetics) Should you start with the foundation (Metformin) or the heavy hitter (GLP-1)? We break down signaling, metabolic impact, and sustainability. Primary anchor: Holman RR, et al. 10-year follow-up of intensive glucose control in type 2 diabetes. N Engl J Med. 2008;359(15):1577-1589. Long-term metformin data. | 5 primary references | 2024 |
| Performance & Burnout A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Exercise Physiology & Cardiorespiratory Fitness) Optimize physical and cognitive performance with evidence-based strategies. From VO2 max testing to metabolic health, the roadmap for peak performance. Primary anchor: Mandsager K, et al. Association of Cardiorespiratory Fitness With Long-term Mortality Among Adults. JAMA Netw Open. 2018;1(6):e183605. | 5 primary references | 2026 |
| Pharmacogenomic Testing: Can Genetics Predict Which Medications Work? A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Diagnostic Imaging & Biomarker Triage) Pharmacogenomic testing reads how your genes handle certain drugs, and it is the one genetic test that changes a prescription today. Who it helps and who can skip it, from Fishtown Medicine in Philadelphia. Primary anchor: Relling MV, Klein TE. "CPIC: Clinical Pharmacogenetics Implementation Consortium of the Pharmacogenomics Research Network." Clinical Pharmacology & Therapeutics. 2011;89(3):464-467. | 5 primary references | 2026 |
| Philadelphia Running Clubs A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Running is a team sport in Philadelphia. A guide to the best local running clubs for community, accountability, and the science of the runner's high. Primary anchor: Holt-Lunstad J, Smith TB, Baker M, et al. "Loneliness and social isolation as risk factors for mortality: a meta-analytic review." Perspectives on Psychological Science, 2015;10(2):227-237. | 5 primary references | 2024 |
| Philly Living: Environmental Defense A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Geroscience & Healthspan Medicine) From the Schuylkill Trail to South Street - managing air, water, noise, and urban life in Philly. Practical health strategies for thriving in the city we love. Primary anchor: American Lung Association. "State of the Air 2024 Report." | 5 primary references | 2024 |
| Pollen in Philadelphia: What to Do at Each Tier A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Geroscience & Healthspan Medicine) A pollen guide for Philadelphia: the tree, grass, and weed calendar, timing antihistamines and nasal steroids, and when to involve an allergist. Primary anchor: Sarfaty M, et al. Views of Allergy Specialists on the Health Effects of Climate Change: Membership Survey of the American Academy of Allergy, Asthma & Immunology. George Mason University & AAAAI; 2015. The source for the prevalence data on allergist-reported increases in pollen season length and severity. | 5 primary references | 2026 |
| Precision Hormones: The BHRT Longevity Strategy A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Health Systems & Clinical Communication) Hormones are not just about libido. Learn how Fishtown Medicine uses Bio-identical Hormone Replacement Therapy (BHRT) to protect your brain, bones, and heart health. Primary anchor: Manson JE, et al. The Women's Health Initiative Hormone Therapy Trials: Update and Overview of Health Outcomes. JAMA. 2013;310(13):1353-1368. | 5 primary references | 2026 |
| Precision Nutrition: Why "Eating Healthy" Is Not a Strategy A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Stop chasing weight loss. Optimize for muscle mass and metabolic flexibility with Medicine 3.0 nutrition. Led by Ashvin Vijayakumar MD. Primary anchor: Simpson SJ, Raubenheimer D. "Obesity: the protein leverage hypothesis." Obesity Reviews. 2005. | 5 primary references | 2026 |
| Prediabetes Care in Philadelphia A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Internal Medicine & Prevention) A1c 5.7 to 6.4 is the window where prediabetes can still be turned around. The workup, CGM trials, training plan, and follow-up we use in Philadelphia. Primary anchor: Knowler, W. C., Barrett-Connor, E., Fowler, S. E., et al.; Diabetes Prevention Program Research Group. (2002). Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. New England Journal of Medicine, 346(6), 393-403. | 5 primary references | 2026 |
| Premature Ejaculation in Men A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) PE is common and rarely talked about. The clinical definition, the medications that work, and the workup that often finds an overlapping cause. Primary anchor: Waldinger MD. "The Neurobiological Approach to Premature Ejaculation." J Urol. 2002. | 5 primary references | 2026 |
| Pressure in the Pipes: A Guide to Hypertension Management A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Health Systems & Clinical Communication) High blood pressure is the 'Silent Killer.' Learn how Fishtown Medicine uses a data-driven approach to manage hypertension and protect your long-term heart health. Primary anchor: SPRINT Research Group. A Randomized Trial of Intensive versus Standard Blood-Pressure Control. N Engl J Med. 2015;373(22):2103-2116. | 5 primary references | 2026 |
| Preventing Alzheimer's: The Medicine 3.0 Approach to Cognitive Longevity A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Address brain fog and protect long-term memory. A Philadelphia primary care practice helping APOE4 carriers and busy professionals build cognitive reserve. Primary anchor: 2024 Alzheimer's Disease Facts and Figures. Alzheimer's Association. Reports that women make up nearly two-thirds of Americans with Alzheimer's. | 5 primary references | 2026 |
| Protect Your Brain: Neuroprotective Strategy A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Geroscience & Healthspan Medicine) Alzheimer's doesn't start when you forget your keys. It starts 20 years earlier. Dr. Ash uses the Bredesen Protocol (Recode 2.0) to identify and plug the met... Primary anchor: Livingston G, et al. "Dementia prevention, intervention, and care: 2020 report of the Lancet Commission." The Lancet. 2020. | 5 primary references | 2024 |
| Rapamycin: Smart Drug or Risky Bet? A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Rapamycin extends life in mice. The human picture is messier. A skeptical physician's review of the most hyped drug in longevity medicine. Primary anchor: Dillman AM, et al. Rapamycin: minimal benefits, maximum risks? GeroScience. 2023. | 5 primary references | 2026 |
| Reading Your Family History A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Geroscience & Healthspan Medicine) A family history of diabetes, dementia, cancer, or aneurysm is information, not a verdict. How to read the metabolic thread running through a family tree and the specific screening decisions it should change. Primary anchor: Lean MEJ, et al. "Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial." The Lancet. 2018;391(10120):541-551. | 5 primary references | 2026 |
| September in Philly: A Doctor's Guide to the Month A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) A Philadelphia doctor's guide to September: timing flu and COVID shots, rebuilding a routine that holds, and keeping one cold from taking the whole house. Primary anchor: DiazGranados, C. A., Dunning, A. J., Kimmel, M., et al. (2014). Efficacy of high-dose versus standard-dose influenza vaccine in older adults. New England Journal of Medicine, 371(7), 635-645. | 5 primary references | 2026 |
| Should You Take a Daily Aspirin? What Changed A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Preventive Cardiology & Lipids) For most people without heart disease, daily aspirin is no longer recommended. What ASPREE and the modern trials showed, what the guidelines now say, and why people who have had a heart attack or stroke should keep taking it. Primary anchor: McNeil JJ, et al. "Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly." New England Journal of Medicine. 2018;379(16):1509-1518. | 5 primary references | 2026 |
| Sleep: The Foundation of Recovery A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Geroscience & Healthspan Medicine) You cannot out-diet or out-train poor sleep. Dr. Ash uses clinical data (HRV, Oura) and CBT-I strategies to reverse insomnia and optimize recovery. Primary anchor: Walker MP. Why We Sleep: Unlocking the Power of Sleep and Dreams. 2017. | 5 primary references | 2024 |
| Small Fiber Neuropathy: When the Burning Is There but the Tests Are Normal A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Burning, tingling feet with normal nerve tests can be small fiber neuropathy. Why standard testing misses it, what causes it, and how it is diagnosed. Primary anchor: Devigili G, Tugnoli V, Penza P, et al. "The diagnostic criteria for small fibre neuropathy: from symptoms to neuropathology." Brain. 2008;131(Pt 7):1912-1925. | 5 primary references | 2026 |
| Spermidine: The Autophagy Compound in Your Food A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) An evidence-based guide to spermidine: how this dietary polyamine triggers autophagy, what the human research finds for the heart and the brain, and why food comes first. Primary anchor: Eisenberg T, Abdellatif M, Schroeder S, et al. Cardioprotection and lifespan extension by the natural polyamine spermidine. Nat Med. 2016. | 5 primary references | 2026 |
| Sphenoid Sinusitis: The Sinus Infection That Doesn't Feel Like One A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) A headache at the crown of the head with heaviness behind the eyes, no facial tenderness, and no congestion can still be a sinus infection. The sphenoid sinus is the one you cannot press on, and azithromycin does not cover it. Primary anchor: Lew D, Southwick FS, Montgomery WW, Weber AL, Baker AS. "Sphenoid Sinusitis: A Review of 30 Cases." New England Journal of Medicine. 1983;309(19):1149-1154. | 5 primary references | 2026 |
| Stem Cells and Exosomes: What the Evidence Shows A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Geroscience & Healthspan Medicine) Clinics sell stem-cell and exosome treatments for joints, aging, and IV longevity. The biology is promising, but the products are mostly unapproved, unproven, and sometimes unsafe. a look at what holds up. Primary anchor: Eggenhofer E, Benseler V, Kroemer A, et al. "Mesenchymal Stem Cells Are Short-Lived and Do Not Migrate Beyond the Lungs After Intravenous Infusion." Frontiers in Immunology. 2012;3:297. | 5 primary references | 2026 |
| Sun Protection for Shore Season A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Geroscience & Healthspan Medicine) How to protect your skin through a Philadelphia summer and a long day at the Jersey Shore: cover up first, use enough sunscreen, and treat a burn right. Primary anchor: Green AC, Williams GM, Logan V, Strutton GM. "Reduced melanoma after regular sunscreen use: randomized trial follow-up." Journal of Clinical Oncology. 2011;29(3):257-263. | 5 primary references | 2026 |
| Symptom Solving A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) Browse our clinical guides on common symptoms. Each one walks you through likely causes, when to act, and how we approach the workup in Philly. Primary anchor: Komaroff AL. "Symptoms: in the head or in the brain?" Annals of Internal Medicine. 2001;134(9 Pt 2):783-785. | 5 primary references | 2026 |
| The AIP Diet: Immune Reset A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Metabolic Medicine & Bioenergetics) More than just clean eating. Discover how the Autoimmune Protocol (AIP) acts as a diagnostic tool to silence inflammation and identify your specific dietary... Primary anchor: Konijeti GG, et al. "Efficacy of the Autoimmune Protocol Diet for Inflammatory Bowel Disease." Inflammatory Bowel Diseases. 2017. | 5 primary references | 2024 |
| The Air Travel Strategy A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Care Coordination & Preventive Protocols) Mitigating the physiological cost of flight. Radiation, dehydration, and circadian defense. Primary anchor: Hypoxia and Cognitive Function: McMorris, T., et al. (2017). "Effect of acute hypoxia on cognition: A systematic review and meta-regression analysis." Neuroscience & Biobehavioral Reviews, 74(Pt A), 225-232. (Meta-analysis showing acute hypoxia produces a moderate negative effect on cognitive performance, relevant to pressurized cabin altitudes.) | 5 primary references | 2024 |
| The Architecture of Facial Aging A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Geroscience & Healthspan Medicine) Facial aging is more than wrinkles: fat pads deflate, bone recedes, ligaments pull. Understanding the layers explains the tired look and what you can control. Primary anchor: Shaw RB Jr, Katzel EB, Koltz PF, et al. "Aging of the facial skeleton: aesthetic implications and rejuvenation strategies." Plastic and Reconstructive Surgery. 2011;127(1):374-383. | 5 primary references | 2026 |
| The blank that arrives when you turn the paper over A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Exercise Physiology & Cardiorespiratory Fitness) Test anxiety has a working-memory mechanism as well as an adrenaline one. What the evidence supports, and why a beta-blocker is a narrower tool here than people expect. Primary anchor: Ramirez G, Beilock SL. Writing about testing worries boosts exam performance in the classroom. Science. 2011;331(6014):211-213. | 5 primary references | 2026 |
| The Clinical Toolkit: Why We Send You to Wirecutter A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Geroscience & Healthspan Medicine) We don't sell gear. We curate efficacy. Here is the vetted list of tools to operationalize your health. Primary anchor: Brook RD, et al. "Particulate Matter Air Pollution and Cardiovascular Disease." Circulation. 2010. | 5 primary references | 2024 |
| The day your zones stop meaning anything A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Therapeutics & Pharmacology) A beta-blocker caps your heart rate for hours, so training zones, wearable data, and VO2 max estimates all read wrong. How to schedule around it. Primary anchor: US Food and Drug Administration. Inderal (propranolol hydrochloride) prescribing information. FDA Access Data. | 5 primary references | 2026 |
| The drink and the tablet pull the same direction A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Therapeutics & Pharmacology) Both lower blood pressure and both are often taken before the same events. What the interaction does, how long to leave between them, and what to do if you already have. Primary anchor: US Food and Drug Administration. Inderal (propranolol hydrochloride) prescribing information, drug interactions. FDA Access Data. | 5 primary references | 2026 |
| The Engine Room A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Metabolic Medicine & Bioenergetics) Why you feel tired at 3 PM, and how to fix it - insulin resistance, glucose swings, and the metabolic testing that catches dysfunction early. Primary anchor: Araújo J, et al. "Prevalence of Optimal Metabolic Health in American Adults: National Health and Nutrition Examination Survey 2009-2016." Metabolic Syndrome and Related Disorders. 2019. | 5 primary references | 2026 |
| The Executive Playbook A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Care Coordination & Preventive Protocols) A high-stakes, data-driven guide to protecting your primary asset: your biology. Pure strategy. Just ROI. Primary anchor: Sniderman, A. D., et al. (2019). Apolipoprotein B Particles and Cardiovascular Disease: A Narrative Review. JAMA Cardiology, 4(12), 1287-1295. | 5 primary references | 2024 |
| The first ninety seconds of a talk A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Exercise Physiology & Cardiorespiratory Fitness) Fear of public speaking has a physiology and a set of levers. What reduces it, what the opening ninety seconds are doing, and where propranolol fits. Primary anchor: Brantigan CO, Brantigan TA, Joseph N. Effect of beta blockade and beta stimulation on stage fright. The American Journal of Medicine. 1982;72(1):88-94. | 5 primary references | 2026 |
| The Foundational Two: Vitamin D and Omega-3 A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Why we test everyone for Vitamin D and Omega-3 Index. The critical link to immunity, mood, and inflammation. Primary anchor: Holick MF. Vitamin D deficiency. N Engl J Med. 2007. | 5 primary references | 2026 |
| The interview your body talked you out of A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Exercise Physiology & Cardiorespiratory Fitness) Why interviews trigger a physical alarm, what reliably reduces it, and where a beta-blocker fits when preparation has already been done. Primary anchor: Brantigan CO, Brantigan TA, Joseph N. Effect of beta blockade and beta stimulation on stage fright. The American Journal of Medicine. 1982;72(1):88-94. | 5 primary references | 2026 |
| The MCAS (Mast Cell) Strategy A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Care Coordination & Preventive Protocols) When you react to the world. Stabilizing the immune system and expanding your life. Primary anchor: Afrin, L. B., et al. (2020). Diagnosis of mast cell activation syndrome: a global consensus-2. Diagnosis, 8(2), 137-152. | 5 primary references | 2024 |
| The Metabolic Reset A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Why semaglutide and tirzepatide are more than diet drugs. They lower inflammation, dampen addiction circuits, and protect the heart. Primary anchor: Lincoff AM, et al. Semaglutide and cardiovascular outcomes in obesity without diabetes. N Engl J Med. 2023. (SELECT trial.) | 5 primary references | 2026 |
| The New York Times is Right (and Wrong) About Supplements A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Why 'just eat whole food' is lazy advice, and why 'take everything' is dangerous. A look at precision medicine and why testing beats guessing. Primary anchor: Holick MF. "The vitamin D deficiency pandemic." Reviews in Endocrine and Metabolic Disorders. 2017. | 5 primary references | 2026 |
| The Nocebo Effect: When Fear Becomes the Symptom A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Internal Medicine & Prevention) The nocebo effect is the placebo's dark twin: expecting harm can produce it. How it shapes pain and side effects, why asking AI about a symptom can make it worse, and how to guard against it, from Fishtown Medicine in Philadelphia. Primary anchor: Colloca L, Barsky AJ. "Placebo and nocebo effects." New England Journal of Medicine. 2020;382(6):554-561. | 5 primary references | 2026 |
| The Philly Health Ecosystem A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) A systems-based guide to the best food, training, and recovery resources in our Philadelphia neighborhoods. Curated by Dr. Ash. Primary anchor: Marmot M, Bell R. "Fair society, healthy lives." Public Health, 2012;126(1):S4-S10. | 5 primary references | 2026 |
| The Pillars of Medicine 3.0 A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Foundational concepts for a longer, healthier life. Primary anchor: Sniderman AD, Thanassoulis G, Glavinovic T, et al. "Apolipoprotein B Particles and Cardiovascular Disease: A Narrative Review." JAMA Cardiology, 2019;4(12):1287-1295. | 5 primary references | 2026 |
| The POTS & Dysautonomia Strategy A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Care Coordination & Preventive Protocols) Why you get dizzy when you stand. Fixing the Autonomic Nervous System. Primary anchor: Vernino, S., et al. (2021). Postural tachycardia syndrome (POTS): State of the science and clinical care from a 2019 NIH Expert Consensus Meeting. Autonomic Neuroscience, 235, 102828. | 5 primary references | 2024 |
| The Radium Tonic Was Sold to Men Who Were Already Healthy A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Geroscience & Healthspan Medicine) Radithor killed a champion golfer in 1932. It was sold to wealthy, fit men who wanted an edge, which is the least-scrutinized corner of medicine. What that should teach a longevity practice about its own field. Primary anchor: Oak Ridge Associated Universities, Museum of Radiation and Radioactivity. "Radithor (ca. 1928)." | 5 primary references | 2026 |
| The Symptom Architecture: How to Decode Your Body's Signals A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Care Coordination & Preventive Protocols) Stop chasing symptoms one at a time. Learn how fatigue, brain fog, and gut issues connect through a three-layer body architecture you can map and fix. Primary anchor: Petersen MC, Shulman GI. "Mechanisms of insulin action and insulin resistance." Physiological Reviews. 2018;98(4):2133-2223. | 5 primary references | 2026 |
| The toast you have been dreading since March A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Exercise Physiology & Cardiorespiratory Fitness) A wedding speech is the one performance you cannot practice your way out of caring about. What helps, why alcohol makes it worse, and where medicine fits. Primary anchor: Brantigan CO, Brantigan TA, Joseph N. Effect of beta blockade and beta stimulation on stage fright. The American Journal of Medicine. 1982;72(1):88-94. | 5 primary references | 2026 |
| The Visceral Fat Audit: Hidden Belly Fat and How to Lose It A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Care Coordination & Preventive Protocols) Visceral fat is the deep belly fat that wraps your liver and pancreas. Learn how cortisol, alcohol, and insulin drive it, and how to lose it safely. Primary anchor: Tchernof A, Despres JP. "Pathophysiology of human visceral obesity: an update." Physiological Reviews. 2013;93(1):359-404. | 5 primary references | 2026 |
| Thyroid Antibodies but Normal TSH? Catching Hashimoto's Before It Needs Medication A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) Your TSH is normal but your thyroid antibodies came back positive? What that means, why standard panels miss it, and what to do in the early window before medication. Primary anchor: Hollowell JG, Staehling NW, Flanders WD, et al. Serum TSH, T4, and thyroid antibodies in the United States population (1988 to 1994): NHANES III. Journal of Clinical Endocrinology and Metabolism. 2002;87(2):489-499. | 5 primary references | 2026 |
| Tired of "Normal" Labs? Why Metabolic Health is the Missing Piece of Your Performance A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Stop settling for "normal" lab results. Our Philadelphia metabolic health clinic uses advanced testing (HOMA-IR, CGM) to detect insulin resistance and optimize energy. Primary anchor: Reaven GM. "Banting lecture 1988: Role of insulin resistance in human disease." Diabetes. 1988. | 5 primary references | 2026 |
| Type 2 Diabetes Reversal: Is Remission Possible? A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Internal Medicine & Prevention) Type 2 diabetes can go into remission, and the odds are highest in the first years after diagnosis. The evidence, what remission means, and how Fishtown Medicine builds a reversal plan in Philadelphia and South Jersey. Primary anchor: Lean MEJ, Leslie WS, Barnes AC, et al. "Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial." Lancet. 2018;391(10120):541-551. | 5 primary references | 2026 |
| Understanding High Blood Pressure at Home A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) Is your blood pressure high at home? Learn how to distinguish between 'White Coat Hypertension' and true risk, and understand the steps to take. Primary anchor: Whelton PK, et al. "2017 ACC/AHA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults." Hypertension. 2018. | 5 primary references | 2026 |
| Understanding Low Libido in Men A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) Sex drive is a key sign. Learn about the root causes of low libido in men, from hormones to stress and metabolism, and how we help you feel like yourself again. Primary anchor: Bhasin S, et al. "Testosterone therapy in men with hypogonadism: an Endocrine Society clinical practice guideline." Journal of Clinical Endocrinology & Metabolism. 2018. | 5 primary references | 2026 |
| Urolithin A: The Mitochondrial Cleanup Molecule A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) An evidence-based guide to urolithin A (the compound in Mitopure): how it triggers mitophagy, what the human trials show for muscle and energy, and who it fits. Primary anchor: Ryu D, et al. Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nat Med. 2016. | 5 primary references | 2026 |
| Walk Your Way to Health in Philly A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Geroscience & Healthspan Medicine) Yes, parking sucks. But Phillys walkability, Indego bikes, and SEPTA (when it shows up) are secret weapons for metabolic health. Heres how to use them. Primary anchor: Lee IM, et al. "Association of Step Volume and Intensity With All-Cause Mortality in Older Women." JAMA Internal Medicine. 2019. | 5 primary references | 2024 |
| Walking Pneumonia and the Philly Cough That Won't Quit A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Internal Medicine & Prevention) A lingering cough is going around Philadelphia. Why walking pneumonia lasts weeks, why a Z-Pak or amoxicillin can miss it, and when antibiotics help. Primary anchor: Centers for Disease Control and Prevention. About Mycoplasma pneumoniae Infection. https://www.cdc.gov/mycoplasma/about/index.html | 5 primary references | 2026 |
| Weight Loss That Works A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Metabolic Medicine & Bioenergetics) A nuance-first approach to GLP-1s. We focus on body composition, not just the number on the scale, with HAES-aligned principles that prioritize health. Primary anchor: Wilding JPH, et al. Once-Weekly Semaglutide in Adults with Overweight or Obesity. N Engl J Med. 2021;384(11):989-1002. The STEP 1 trial. | 5 primary references | 2024 |
| What if my low energy isn't depression? A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) Not all fatigue is in your head. Learn how Fishtown Medicine investigates the biological root causes of low energy, from thyroid to mitochondrial health. Primary anchor: Holton KF. "Micronutrients and chronic fatigue." Nutrients. 2016. | 5 primary references | 2026 |
| What Is a Preventive Cardiologist, and Do You Need One? A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Preventive Cardiology & Lipids) A preventive cardiologist works to stop heart disease before it starts. How that differs from a regular cardiologist, and when advanced primary care can lead the prevention. Primary anchor: Arnett DK, Blumenthal RS, Albert MA, et al. "2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease." Journal of the American College of Cardiology. 2019;74(10):e177-e232. | 5 primary references | 2026 |
| What Is Medicine 3.0? Moving from Reactive to Proactive Health A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) What Medicine 3.0 means and how a Philadelphia primary care practice uses it to extend healthspan rather than lifespan alone. Primary anchor: Attia P. Outlive: The Science and Art of Longevity. Harmony/Rodale; 2023. | 5 primary references | 2026 |
| What it feels like, and what to do about it A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Therapeutics & Pharmacology) Most side effects follow directly from the mechanism. Which ones to expect at situational doses, which belong to daily use, and the ones that mean stop now. Primary anchor: US Food and Drug Administration. Inderal (propranolol hydrochloride) prescribing information, adverse reactions. FDA Access Data. | 5 primary references | 2026 |
| What Longevity Medicine Costs, and What You Are Paying For A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Geroscience & Healthspan Medicine) Concierge longevity programs run from a few thousand to over $60,000 a year. A clear look at what is inside those fees, which parts are the medicine, and how a direct primary care membership delivers the same clinical work. Primary anchor: Attia P. Outlive: The Science and Art of Longevity. Harmony; 2023. | 5 primary references | 2026 |
| When You Feel Dismissed by Your Doctor A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Health Systems & Clinical Communication) Medical gaslighting is when your symptoms are minimized or blamed on stress without a proper workup. What it is, why it happens more often than it should, how to tell it from earned reassurance, and how to be heard, from Fishtown Medicine in Philadelphia. Primary anchor: Fraser S. "The clinical concept of medical gaslighting and its implications for the patient-clinician relationship." Discussion of dismissal and epistemic injustice in clinical care, 2023. | 5 primary references | 2026 |
| Why "Low T" is the Wrong Metric: Precision Men's Health A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Stop settling for "normal." Fishtown Medicine offers precision TRT and fertility-preserving strategies (HCG, Enclomiphene) for driven men in Philadelphia. Primary anchor: Lincoff AM, et al. "Cardiovascular safety of testosterone-replacement therapy." NEJM. 2023. (TRAVERSE Trial) | 5 primary references | 2026 |
| Why 8 Hours of Sleep is the Wrong Metric: Sleep Architecture in Medicine 3.0 A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Optimize your sleep architecture for longevity. We use Oura, Whoop, and Apple Watch data to dial in REM and Deep Sleep. Led by Ashvin Vijayakumar MD. Primary anchor: Xie L, et al. "Sleep drives metabolite clearance from the adult brain." Science. 2013. | 5 primary references | 2026 |
| Why Am I Always Exhausted? A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) Exhausted despite 8 hours of sleep? Stop guessing. We treat the root metabolic and hormonal causes of fatigue in Philadelphia, beyond the 'adrenal fatigue' label. Primary anchor: Cleare AJ. "The HPA axis and the genesis of chronic fatigue syndrome." Trends in Endocrinology & Metabolism. 2004. | 5 primary references | 2024 |
| Why Your HDL Stays Stuck A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Preventive Cardiology & Lipids) Triglycerides down, LDL down, A1C down, and HDL still stuck or even lower. Why HDL is the slowest lipid marker to respond, what moves it, and why the number matters less than the pattern around it. Primary anchor: Boden WE, et al. "Niacin in Patients with Low HDL Cholesterol Levels Receiving Intensive Statin Therapy" (AIM-HIGH). New England Journal of Medicine. 2011;365(24):2255-2267. | 5 primary references | 2026 |
| Your CRP Came Back High: What It Means A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Diagnostic Imaging & Biomarker Triage) A high CRP means inflammation somewhere in the body. What raises it, how high is too high, and the workup a stubbornly elevated CRP deserves. Primary anchor: Sproston NR, Ashworth JJ. "Role of C-Reactive Protein at Sites of Inflammation and Infection." Frontiers in Immunology. 2018;9:754. | 5 primary references | 2026 |
| Your Relationship With Yourself A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) The relationships that shape your health reach beyond other people. The first one is with yourself: the story you tell, whether you choose yourself, and how you talk to yourself when it is hard. Why that relationship decides whether a health change sticks, from Fishtown Medicine in Philadelphia. Primary anchor: Ryan RM, Deci EL. Self-determination theory and the facilitation of intrinsic motivation, social development, and well-being. American Psychologist. 2000;55(1):68-78. | 5 primary references | 2026 |
| A Mouthwash Invented a Disease, and It Worked A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Internal Medicine & Prevention) Listerine popularized the word halitosis in the 1920s and revenue went from $115,000 to over $8 million in seven years. How manufactured conditions work, and how to tell one from a condition that is simply being ignored. Primary anchor: Smithsonian Magazine. "How Halitosis Became a Medical Condition With a 'Cure.'" | 4 primary references | 2026 |
| Abdominal and Pelvic Imaging Guide A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Diagnostic Imaging & Biomarker Triage) Persistent belly or pelvic pain? Learn about Ultrasound, CT, and MRI scans for abdominal health, and how Fishtown Medicine chooses the right test for you. Primary anchor: American College of Radiology. "ACR Appropriateness Criteria: Right Lower Quadrant Pain." 2023. | 4 primary references | 2026 |
| ADHD Paralysis: Why You Can't Start A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) ADHD paralysis is the frozen, can't-start feeling that comes from executive dysfunction, not laziness. What task paralysis, choice paralysis, and overwhelm paralysis are, why the ADHD brain freezes, and practical ways to get moving, from Fishtown Medicine in Philadelphia. Primary anchor: Barkley RA. Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD. Psychol Bull. 1997;121(1):65-94. | 4 primary references | 2026 |
| Adult ADHD Symptoms & the 3 Types A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) What ADHD looks like in adults, the nine inattentive and nine hyperactive-impulsive symptoms in plain language, the three presentations (inattentive, hyperactive-impulsive, and combined), and how severity is rated. A physician's overview from Fishtown Medicine in Philadelphia. Primary anchor: American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 5th ed, Text Revision (DSM-5-TR). 2022. | 4 primary references | 2026 |
| ApoB vs LDL: Why Your "Normal" Cholesterol Score Might Be Misleading A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) A guide to ApoB vs LDL and why a normal cholesterol report can still hide serious heart risk. From a Medicine 3.0 practice in Philadelphia. Primary anchor: Sniderman AD, et al. Apolipoprotein B Particles and Cardiovascular Disease: A Narrative Review. JAMA Cardiol. 2019;4(12):1287-1295. | 4 primary references | 2026 |
| April in Philly: A Doctor's Guide to the Month A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) A Philadelphia doctor's guide to April: spring labs worth rechecking, an allergy plan that holds through peak pollen, and training safely for Broad Street. Primary anchor: Holick, M. F. (2007). Vitamin D deficiency. New England Journal of Medicine, 357(3), 266-281. | 4 primary references | 2026 |
| Beyond Labels: Our Stance on Integrative and Functional Medicine A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Health Systems & Clinical Communication) Understand how Fishtown Medicine integrates the best of conventional, integrative, and functional medicine to provide a systems-thinking approach to your health. Primary anchor: Snyderman R, Dinan MA. Improving Health by Taking It Personally. JAMA. 2010;303(4):363-364. | 4 primary references | 2026 |
| Beyond the Scale: Why We Focus on Body Composition, Not Weight Loss A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Move beyond the scale. We focus on muscle mass and metabolic health using DEXA scans, in a HAES-aligned, Medicine 3.0 practice in Philadelphia. Primary anchor: Spiegelman BM, Flier JS. Adipose tissue as an endocrine organ. Cell. Discusses how fat tissue secretes hormones and inflammatory signals. | 4 primary references | 2026 |
| BHRT: Safety First. A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Endocrinology & Reproductive Health) Hormone optimization can be life-changing, but it carries real risks. We offer a cardiologist-grade safety strategy for Bioidentical Hormone Replacement. Primary anchor: The 2022 Hormone Therapy Position Statement of The North American Menopause Society. Menopause. 2022;29(7):767-794. | 4 primary references | 2026 |
| Biotin: More Than Just Hair & Nails A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Evidence-based guide to Biotin. Learn about the '2,500mcg' sweet spot for nails, preventing supplement acne, and critical FDA warnings on lab interference. Primary anchor: Colombo VE et al. "Treatment of brittle fingernails and onychoschizia with biotin: scanning electron microscopy." Journal of the American Academy of Dermatology. 1990. | 4 primary references | 2024 |
| Black Pepper: The Bioavailability Booster A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Evidence-based guide to Piperine (BioPerine). Learn how to use it to amplify Curcumin and CoQ10, and why managing the 'drug interaction window' is critical for safety. Primary anchor: Shoba G, Joy D, Joseph T, et al. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med. 1998;64(4):353-356. | 4 primary references | 2024 |
| Bone and Joint Imaging 101 A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Diagnostic Imaging & Biomarker Triage) X-rays, ultrasounds, and MRIs for bone and joint health, and how Fishtown Medicine helps you find the right path to recovery. Primary anchor: Brinjikji W, et al. "Systematic Literature Review of Imaging Features of Spinal Degeneration in Asymptomatic Populations." American Journal of Neuroradiology. 2015. | 4 primary references | 2026 |
| Boutique Scans & Whole-Body MRI: A Clinical Review A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Diagnostic Imaging & Biomarker Triage) Is a full-body MRI worth it? Learn the pros and cons of boutique screening MRIs and PET-CTs, and how Fishtown Medicine chooses the right cancer detection strategy. Primary anchor: Hricak H, et al. "Medical imaging and nuclear medicine: a Lancet Oncology Commission." The Lancet Oncology. 2021. | 4 primary references | 2026 |
| Building Your Health History: How to Share Previous Records A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Health Systems & Clinical Communication) Ensure continuity of care. Learn how to securely share your previous medical records, labs, and imaging results with Dr. Ash for a more complete health assessment. Primary anchor: U.S. Department of Health & Human Services. "HIPAA Privacy Rule and Patient Access to Health Information." HHS.gov. 2024. | 4 primary references | 2026 |
| Chromium: The Insulin Sensitizer A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) A clinical guide to chromium supplementation for blood sugar stability, insulin sensitivity, and metabolic health. Primary anchor: Anderson RA. (1998). "Effects of chromium on body composition and weight loss." Nutrition Reviews, 56(9), 266-270. | 4 primary references | 2025 |
| Chronic vs. Episodic Migraine A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Episodic migraine means 14 or fewer headache days a month; chronic migraine means 15 or more for at least three months. How attacks slide from one to the other, the medication-overuse trap that drives it, and how to move back, from Fishtown Medicine in Philadelphia. Primary anchor: Headache Classification Committee of the International Headache Society (IHS). The International Classification of Headache Disorders, 3rd edition (ICHD-3). Cephalalgia. 2018;38(1):1-211. | 4 primary references | 2026 |
| CIMT vs Calcium Score: Which Early-Detection Test Is Right? A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Diagnostic Imaging & Biomarker Triage) A CIMT (carotid ultrasound) and a coronary calcium score both look for early artery disease, but they find different things. Which test fits which person, and how Fishtown Medicine chooses in Philadelphia and South Jersey. Primary anchor: Nambi V, Chambless L, Folsom AR, et al. "Carotid intima-media thickness and presence or absence of plaque improves prediction of coronary heart disease risk: the ARIC study." Journal of the American College of Cardiology. 2010;55(15):1600-1607. | 4 primary references | 2026 |
| Clinical Guide: Cleerly CTA Analysis A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Diagnostic Imaging & Biomarker Triage) The Heart Attack Forecast. Using AI to phenotype your arterial plaque (Soft vs. Calcified). Moving beyond the Calcium Score. Primary anchor: Min JK, et al. "Coronary CTA-derived plaque characteristics and the prediction of major adverse cardiovascular events." JACC: Cardiovascular Imaging. 2022. | 4 primary references | 2024 |
| Clinical Guide: Grail Galleri Test A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Diagnostic Imaging & Biomarker Triage) Multi-Cancer Early Detection (MCED). Screening for 50+ types of cancer via cell-free DNA methylation patterns. Primary anchor: Klein EA, et al. "Clinical validation of a targeted methylation-based multi-cancer early detection test using an independent validation set." Annals of Oncology. 2021. | 4 primary references | 2024 |
| Clinical Guide: Whole Genome Sequencing (WGS) A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Diagnostic Imaging & Biomarker Triage) The difference between genotyping (23andMe) and WGS. Analyzing 100% of your DNA for longevity, pharmacogenomics, and rare disease risk. Primary anchor: Manolio TA, et al. "Implementing genomic medicine in the clinic: the future is here." Genetics in Medicine. 2013. | 4 primary references | 2026 |
| Colorectal Cancer Screening: Which Test, and When? A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Diagnostic Imaging & Biomarker Triage) Screening now starts at 45, and colorectal cancer is one of the most preventable cancers. How colonoscopy, FIT, Cologuard, and the new blood tests compare, and how Fishtown Medicine helps you choose in Philadelphia. Primary anchor: US Preventive Services Task Force. "Screening for Colorectal Cancer: US Preventive Services Task Force Recommendation Statement." JAMA. 2021;325(19):1965-1977. | 4 primary references | 2026 |
| Compounded GLP-1 Drugs: Safe? Legal? What Changed in 2026 A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Metabolic Medicine & Bioenergetics) Compounded semaglutide and tirzepatide after the shortages ended: what compounding is, why the legal path narrowed in 2025 and 2026, the safety questions, the price gap, and what to ask your physician. Primary anchor: US Food and Drug Administration. "FDA Clarifies Policies for Compounders as National GLP-1 Supply Begins to Stabilize." 2025. | 4 primary references | 2026 |
| Connecting the Dots: The Systems-Thinking Approach to Diagnosis A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Health Systems & Clinical Communication) Discover how Fishtown Medicine identifies root causes by connecting symptoms across body systems for a more accurate diagnostic picture. Primary anchor: Reaven GM. "Insulin resistance: the link between obesity and cardiovascular disease." Medical Clinics of North America. 2011. | 4 primary references | 2026 |
| Counterfeit Skincare and Supplements A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Geroscience & Healthspan Medicine) Third-party marketplaces are full of fake, diverted, and expired skincare and supplements. Why it matters for your body, and how to buy safely. Primary anchor: U.S. Customs and Border Protection. "Intellectual Property Rights Seizure Statistics: Fiscal Year 2024." 2025. | 4 primary references | 2026 |
| Dandruff & Seborrheic Dermatitis A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) Dandruff and seborrheic dermatitis are a treatable, yeast-driven scalp problem, not poor hygiene. The shampoo ladder, prescriptions, and the hair loss link. Primary anchor: Borda LJ, Wikramanayake TC. "Seborrheic Dermatitis and Dandruff: A Comprehensive Review." Journal of Clinical and Investigative Dermatology. 2015;3(2). | 4 primary references | 2026 |
| December in Philly: A Doctor's Guide to the Month A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) A Philadelphia doctor's guide to December: using year-end FSA dollars before they expire, holding your health steady through holiday weeks, keeping norovirus out of your kitchen, and picking the question January should answer. Primary anchor: Hall, A. J., Lopman, B. A., Payne, D. C., et al. (2013). Norovirus disease in the United States. Emerging Infectious Diseases, 19(8), 1198-1205. | 4 primary references | 2026 |
| Do Statins Cause Diabetes? A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Preventive Cardiology & Lipids) Statins slightly raise diabetes risk, but the effect is small and concentrated in people already near diabetes, and the heart benefit outweighs it. What the Sattar, Preiss, and JUPITER analyses show, and what to do. Primary anchor: Sattar N, Preiss D, Murray HM, et al. "Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials." Lancet. 2010;375(9716):735-742. | 4 primary references | 2026 |
| Doctor Won't Refill Your Medication? How to Bridge the Gap in Philadelphia A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Running out of a medication that works because of 30-day limits, online denials, or an unreachable office? How refill gaps happen and how we close them. Primary anchor: Fava GA, Gatti A, Belaise C, Guidi J, Offidani E. Withdrawal symptoms after selective serotonin reuptake inhibitor discontinuation: a systematic review. Psychotherapy and Psychosomatics. 2015;84(2):72-81. | 4 primary references | 2026 |
| Drug-Free Migraine Prevention A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Migraine can be prevented without medication for many people, using an evidence-based stack: magnesium, riboflavin, and CoQ10, a steady sleep and meal routine, trigger tracking, and neuromodulation. What the research supports and how to build it, from Fishtown Medicine in Philadelphia. Primary anchor: Holland S, et al. Evidence-based guideline update: NSAIDs and other complementary treatments for episodic migraine prevention in adults. Neurology. 2012;78(17):1346-1353. | 4 primary references | 2026 |
| Eating for Testosterone: Myth vs. Science A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Endocrinology & Reproductive Health) Testosterone is just the fuel. Your lifestyle is the engine. Dr. Ash details the nutrition, sleep, and training strategies needed to manage andropause. Primary anchor: Leproult R, Van Cauter E. "Effect of 1 week of sleep restriction on testosterone levels in young healthy men." JAMA. 2011;305(21):2173-2174. | 4 primary references | 2024 |
| ED: The Vascular Warning Sign A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Preventive Cardiology & Lipids) ED is often the earliest warning sign of cardiovascular risk. Learn how to treat the vascular root cause rather than the symptom alone. Primary anchor: Gandaglia G, et al. "A systematic review of the association between erectile dysfunction and cardiovascular disease." European Urology. 2014. | 4 primary references | 2024 |
| Emerging Science and Strategies A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) A guide to the frontier of longevity, metabolic optimization, and precision medicine. Evidence-based, no hype. Primary anchor: López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. "The Hallmarks of Aging." Cell, 2013;153(6):1194-1217. | 4 primary references | 2026 |
| Executive Physicals: Strategy vs. Checkboxes A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Why a 'one-day physical' is often a poor use of $3,000, and how a relationship-based model gives executives better long-term value. Primary anchor: Sniderman AD, et al. Apolipoprotein B Particles and Cardiovascular Disease: A Narrative Review. JAMA Cardiology. 2019. Evidence supporting ApoB as a sharper cardiovascular risk marker than LDL alone. | 4 primary references | 2026 |
| February in Philly: A Doctor's Guide to the Month A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) A Philadelphia doctor's guide to February: the heart numbers to check before anything hurts, how to take your blood pressure at home properly, and getting through the heaviest stretch of winter. Primary anchor: Sniderman, A. D., Thanassoulis, G., Glavinovic, T., et al. (2019). Apolipoprotein B particles and cardiovascular disease: a narrative review. JAMA Cardiology, 4(12), 1287-1295. | 4 primary references | 2026 |
| For the Magpie Community: Integrative Primary Care That Honors Your Choices A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Internal Medicine & Prevention) Dr. Ash partners with Magpie Midwifery families - hormone support, pre- conception care, postpartum recovery, and whole-person primary care. Primary anchor: ACOG Committee Opinion No. 762: Prepregnancy Counseling. Obstetrics and Gynecology. 2019. | 4 primary references | 2026 |
| Full-Body MRI Screening A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Diagnostic Imaging & Biomarker Triage) Detecting cancer, aneurysm, and structural issues before they cause symptoms. A clear, clinical focus on early detection strategy. Primary anchor: Hricak H, et al. "Medical imaging and nuclear medicine: a Lancet Oncology Commission." The Lancet Oncology. 2021. | 4 primary references | 2024 |
| Function Health: The Missing Half A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) A clinical guide for Philadelphians using Function Health. How to turn 100+ lab biomarkers into a medical plan with a local physician. Primary anchor: Sniderman AD, et al. Apolipoprotein B Particles and Cardiovascular Disease: A Narrative Review. JAMA Cardiology. 2019. Evidence supporting ApoB as a sharper cardiovascular risk marker than LDL alone. | 4 primary references | 2025 |
| GLP-1 Drugs and Surgery: Do You Have to Stop Before a Procedure? A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Metabolic Medicine & Bioenergetics) Most people can safely continue Ozempic, Wegovy, or Mounjaro before surgery. The 2024 multisociety guidance, why the old week-long hold is out of date, the aspiration risk, and how your care team decides. Primary anchor: American Society of Anesthesiologists, American Gastroenterological Association, American Society for Metabolic and Bariatric Surgery, International Society of Perioperative Care of Patients with Obesity, and Society of American Gastrointestinal and Endoscopic Surgeons. "Multisociety Clinical Practice Guidance for the Safe Use of Glucagon-like Peptide-1 Receptor Agonists in the Perioperative Period." Clinical Gastroenterology and Hepatology; Surgical Endoscopy; Surgery for Obesity and Related Diseases. 2024. | 4 primary references | 2026 |
| GLP-1 Medications vs Bariatric Surgery: How to Choose A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Metabolic Medicine & Bioenergetics) GLP-1 medications and bariatric surgery both drive major weight loss and can reverse diabetes, but they differ in size, durability, and trade-offs. How they compare, who fits which, and how Fishtown Medicine helps you decide. Primary anchor: Jastreboff AM, Aronne LJ, Ahmad NN, et al. "Tirzepatide Once Weekly for the Treatment of Obesity." New England Journal of Medicine. 2022;387(3):205-216. | 4 primary references | 2026 |
| Healthy Dining in Philadelphia A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) How to enjoy Philadelphia's restaurant scene without giving up your metabolic health. A guide to sourcing, menu choices, and specific local picks. Primary anchor: DiNicolantonio JJ, O'Keefe JH. Omega-6 vegetable oils as a driver of coronary heart disease: the oxidized linoleic acid hypothesis. Open Heart. 2018;5(2):e000898. | 4 primary references | 2026 |
| Hearing Loss and Dementia: The Risk Few People Treat A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Geroscience & Healthspan Medicine) Hearing loss is the largest single modifiable risk factor for dementia, yet it goes untreated for years. Why the link is strong, what hearing aids can and can't do, and how Fishtown Medicine builds it into brain-health prevention. Primary anchor: Livingston G, Huntley J, Sommerlad A, et al. "Dementia prevention, intervention, and care: 2020 report of the Lancet Commission." Lancet. 2020;396(10248):413-446. | 4 primary references | 2026 |
| Heart & Vascular Imaging: Beyond the ECG A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Diagnostic Imaging & Biomarker Triage) Is your heart healthy? Learn about Calcium Score CTs, Echocardiograms, and Coronary CTAs, and why Fishtown Medicine uses advanced imaging to rule out heart disease. Primary anchor: Gulati M, et al. "2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR Guideline for the Evaluation and Diagnosis of Chest Pain." Journal of the American College of Cardiology. 2021. | 4 primary references | 2026 |
| Heart Health & Risk A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Preventive Cardiology & Lipids) Proactive strategies to protect your heart and blood vessels. Primary anchor: Sniderman AD, et al. "Apolipoprotein B Particles and Cardiovascular Disease." JAMA Cardiology. 2019. | 4 primary references | 2026 |
| High Homocysteine: What It Means and How to Lower It A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Diagnostic Imaging & Biomarker Triage) Homocysteine is a blood marker tied to heart, stroke, and brain risk, and it is usually fixable. What a high level means, the MTHFR question, what the evidence really shows, and how Fishtown Medicine reads it in Philadelphia. Primary anchor: Homocysteine Studies Collaboration. "Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis." JAMA. 2002;288(16):2015-2022. | 4 primary references | 2026 |
| Hormonal Optimization A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Endocrinology & Reproductive Health) Balance your hormones for better mood, energy, and health. Primary anchor: Bhasin S, et al. "Testosterone Therapy in Men With Hypogonadism: An Endocrine Society Clinical Practice Guideline." Journal of Clinical Endocrinology and Metabolism. 2018. | 4 primary references | 2026 |
| Hormone Testing Before Birth Control: What Helps A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Endocrinology & Reproductive Health) Test-first birth control services promise to match you to the right pill with hormone and DNA testing. A Philadelphia physician on what testing can and cannot predict, and what finding your fit takes. Primary anchor: Nguyen AT, Curtis KM, Tepper NK, et al. U.S. Medical Eligibility Criteria for Contraceptive Use, 2024. MMWR Recommendations and Reports. 2024;73(RR-4):1-126. | 4 primary references | 2026 |
| How We Review Genetic Results A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Diagnostic Imaging & Biomarker Triage) Have your raw DNA data? Learn how Fishtown Medicine interprets your genetic reports to build a personalized prevention strategy for longevity. Primary anchor: Khera AV, et al. "Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations." Nature Genetics. 2018. | 4 primary references | 2026 |
| Hurt Your Knee? Here Is How We Evaluate It A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) Yes, Fishtown Medicine evaluates knee injuries, sprains, and pain that lingers after a fall or a twist, usually same or next day. How the exam works, when imaging helps, and when a knee needs the ER instead. Primary anchor: Stiell IG, Greenberg GH, Wells GA, et al. "Prospective Validation of a Decision Rule for the Use of Radiography in Acute Knee Injuries." JAMA. 1996;275(8):611-615. | 4 primary references | 2026 |
| Icosapent Ethyl (Vascepa): The Prescription Omega-3, and the Debate A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Preventive Cardiology & Lipids) Icosapent ethyl (Vascepa) is prescription EPA that lowered cardiovascular events by 25% in one big trial, but the benefit is debated. What REDUCE-IT showed, the STRENGTH and mineral-oil controversy, and why it is not fish oil. Primary anchor: Bhatt DL, Steg PG, Miller M, et al. "Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia." New England Journal of Medicine. 2019;380(1):11-23. | 4 primary references | 2026 |
| Inositol: The PCOS Workhorse A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Evidence-based guide to myo-inositol and D-chiro-inositol. Why the 40:1 ratio matters for PCOS, insulin resistance, ovulation, and metabolic health. Primary anchor: Unfer V, Facchinetti F, Orrù B, et al. Myo-inositol effects in women with PCOS: a meta-analysis of randomized controlled trials. Endocr Connect. 2017;6(8):647-658. | 4 primary references | 2026 |
| Insulin Resistance at a Normal Weight A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Metabolic Medicine & Bioenergetics) A study of 6,247 young adults without diabetes found 4 in 10 had insulin resistance, and close to half were not obese. What that means for your labs. Primary anchor: Parcha V, Heindl B, Kalra R, Li P, Gower B, Arora G, Arora P. "Insulin Resistance and Cardiometabolic Risk Profile Among Nondiabetic American Young Adults: Insights From NHANES." The Journal of Clinical Endocrinology and Metabolism. 2022;107(1):e25-e37. Journal | 4 primary references | 2026 |
| Iron, Heavy Periods, and Hair Loss A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) Heavy periods slowly drain iron, and low ferritin sheds hair long before anemia shows. Here's the connection, the targets, and the gentler iron forms. Primary anchor: Trost LB, Bergfeld WF, Calogeras E. The diagnosis and treatment of iron deficiency and its potential relationship to hair loss. J Am Acad Dermatol. 2006;54(5):824-844. | 4 primary references | 2026 |
| June in Philly: A Doctor's Guide to the Month A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) A Philadelphia doctor's guide to June: the hydration habit that carries the whole summer, travel without a medication scramble, and a plan for smoke season before it arrives. Primary anchor: Dockery, D. W., Pope, C. A., Xu, X., et al. (1993). An association between air pollution and mortality in six U.S. cities. New England Journal of Medicine, 329(24), 1753-1759. | 4 primary references | 2026 |
| Know Where to Go: The Emergency and Urgent Care Guide A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Health Systems & Clinical Communication) Learn how to navigate medical needs at Fishtown Medicine. Understand when to text your doctor, when to seek urgent care, and when to go to the ER. Primary anchor: Pines JM, et al. "The Effect of Emergency Department Crowding on Patient-Reported Outcomes." Annals of Emergency Medicine. 2009. | 4 primary references | 2026 |
| L-Glutamine: The 'Brick and Mortar' for Your Gut Lining A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Stop just 'soothing' your gut. Learn how L-Glutamine repairs the physical structure of your intestinal lining, boosts immunity, and speeds up recovery. Primary anchor: Kim, M. H., & Kim, H. (2017). The Roles of Glutamine in the Intestine and Its Implication in Intestinal Diseases. International Journal of Molecular Sciences, 18(5), 1051. | 4 primary references | 2026 |
| L-Tyrosine: Focus Under Pressure A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Evidence-based guide to L-Tyrosine. The 'Executive Fuel' for busy professionals running on empty. Case study: Transforming a VP's focus and trajectory. Primary anchor: Jongkees, B. J., et al. (2015). Effect of tyrosine supplementation on clinical and healthy populations under stress or cognitive demands: A review. Journal of Psychiatric Research, 70, 50-57. | 4 primary references | 2026 |
| Lab Testing Memberships: 100 Biomarkers, Then What? A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Internal Medicine & Prevention) Lab memberships and wearable blood panels hand you 50 to 160 biomarkers and a dashboard. A Philadelphia physician on what the results can and cannot tell you, and how to turn them into care. Primary anchor: Sniderman AD, Thanassoulis G, Glavinovic T, et al. Apolipoprotein B Particles and Cardiovascular Disease: A Narrative Review. JAMA Cardiology. 2019;4(12):1287-1295. | 4 primary references | 2026 |
| Lion's Mane: Neurogenesis & Mental Clarity A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Evidence-based guide to Lion's Mane. Learn about Nerve Growth Factor (NGF), why 'Fruiting Body' matters, and dosing for cognitive endurance. Primary anchor: Mori, K., et al. (2009). Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: A double-blind placebo-controlled clinical trial. Phytotherapy Research, 23(3), 367-372. | 4 primary references | 2026 |
| Longevity & Healthspan A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Geroscience & Healthspan Medicine) Strategies to extend your healthspan and optimize lifespan in Philadelphia. Primary anchor: Mandsager K, et al. (2018). Association of Cardiorespiratory Fitness With Long-term Mortality Among Adults Undergoing Exercise Treadmill Testing. JAMA Network Open. | 4 primary references | 2026 |
| Lowering Lp(a): The First Drugs That Can A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Preventive Cardiology & Lipids) For decades Lp(a) was an untreatable genetic heart risk. New drugs like pelacarsen and olpasiran now lower it by 80 to 95%. How they work, and the catch: whether that prevents heart attacks is still being tested. Primary anchor: Tsimikas S, Karwatowska-Prokopczuk E, Gouni-Berthold I, et al. "Lipoprotein(a) Reduction in Persons with Cardiovascular Disease." New England Journal of Medicine. 2020;382(3):244-255. | 4 primary references | 2026 |
| Lp(a): The Genetic Heart Risk A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Preventive Cardiology & Lipids) You can have perfect cholesterol and still be at risk. Learn the science of Lipoprotein(a), the genetic particle that standard blood tests miss. Primary anchor: Kronenberg F, et al. "Lipoprotein(a) in atherosclerotic cardiovascular disease and aortic stenosis: a European Atherosclerosis Society consensus statement." European Heart Journal. 2022. | 4 primary references | 2024 |
| Magnesium: The 300-Enzyme Essential A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Why generic magnesium fails for anxiety. Learn how Glycinate specifically targets the NMDA receptor to turn off 'fight or flight' without sedation. Primary anchor: Boyle, N. B., Lawton, C., & Dye, L. (2017). The Effects of Magnesium Supplementation on Subjective Anxiety and Stress: A Systematic Review. Nutrients, 9(5), 429. | 4 primary references | 2026 |
| Male Fertility: Its Not Just Her A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Endocrinology & Reproductive Health) TRT does not have to mean infertility. Dr. Ash uses HCG and Enclomiphene strategies to protect testicular function and sperm count while optimizing testosterone. Primary anchor: Hsieh TC, et al. "Concomitant intramuscular human chorionic gonadotropin preserves spermatogenesis in men undergoing testosterone replacement therapy." Journal of Urology. 2013;189(2):647-650. | 4 primary references | 2024 |
| Managing ADHD: Systems That Stick A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Ordinary productivity advice fails ADHD because it assumes an executive system that ADHD strains. The systems that hold, externalizing everything, reducing friction, body doubling, using dopamine on purpose, and the sleep, movement, and nutrition foundations underneath. From Fishtown Medicine in Philadelphia. Primary anchor: Safren SA, et al. Cognitive behavioral therapy vs relaxation with educational support for medication-treated adults with ADHD and persistent symptoms: a randomized controlled trial. JAMA. 2010;304(8):875-880. | 4 primary references | 2026 |
| Managing Labs and Imaging with Ease A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Diagnostic Imaging & Biomarker Triage) Confused about where to go for labs or scans? Learn how Fishtown Medicine helps you manage local Philadelphia diagnostics while maximizing your insurance coverage. Primary anchor: Office of the Assistant Secretary for Planning and Evaluation. "No Surprises Act Final Rule." 2022. | 4 primary references | 2026 |
| Melatonin: The Master Antioxidant A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Evidence-based guide to Melatonin. Learn why less is more (0.3mg), how to use it for jet lag, and its role in neuroprotection. Primary anchor: Ferracioli-Oda, E., Qawasmi, A., & Bloch, M. H. (2013). Meta-Analysis: Melatonin for the Treatment of Primary Sleep Disorders. PLoS ONE, 8(5), e63773. | 4 primary references | 2026 |
| Michelin Guide: A Metabolic Audit A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Michelin has arrived in Philadelphia. We look at the winners through a Medicine 3.0 lens: how to enjoy Philly's best food without breaking your biology. Primary anchor: Michelin Guide 2025/2026. Philadelphia Launch. Source for the inaugural awards and selection criteria. | 4 primary references | 2024 |
| Migraine in Women A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Migraine is about three times more common in women, and much of the reason is estrogen. How falling estrogen triggers menstrual migraine, why attacks often ease in pregnancy and flare in perimenopause, and how hormonal migraine is treated, from Fishtown Medicine in Philadelphia. Primary anchor: Headache Classification Committee of the International Headache Society (IHS). The International Classification of Headache Disorders, 3rd edition (ICHD-3). Cephalalgia. 2018;38(1):1-211. | 4 primary references | 2026 |
| Milk Thistle (Silymarin): The Liver Protector A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) A clinical guide to milk thistle, what the evidence shows for liver health, detoxification, and metabolic support. Primary anchor: Abenavoli, L., et al. (2010). Milk thistle in liver diseases: past, present, future. Phytotherapy Research, 24(10), 1423-1432. | 4 primary references | 2026 |
| MTHFR: The 'Anxiety' Gene? A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) 40% of people have this genetic variant. It affects how you process folate, detoxify, and make neurotransmitters. Stop guessing and test. Primary anchor: Rozen, R. (2001). Genetic predisposition to hyperhomocysteinemia: deficiency of methylenetetrahydrofolate reductase (MTHFR). Thrombosis and Haemostasis, 86(1), 60-66. | 4 primary references | 2026 |
| November in Philly: A Doctor's Guide to the Month A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) A Philadelphia doctor's guide to November: protecting sleep as the calendar fills, handling the early dark and low mood, and holding a kind rhythm through the holidays without an all-or-nothing plan. Primary anchor: Golden, R. N., Gaynes, B. N., Ekstrom, R. D., et al. (2005). The efficacy of light therapy in the treatment of mood disorders: a review and meta-analysis of the evidence. American Journal of Psychiatry, 162(4), 656-662. | 4 primary references | 2026 |
| Omega-3: The Essential Anti-Inflammatory A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Why standard fish oil is often under-dosed. The Medicine 3.0 approach: targeting an Omega-3 Index of 12 to 15% with precision EPA and DHA dosing. Primary anchor: Harris, W. S., et al. (2017). The Omega-3 Index and relative risk for coronary heart disease mortality: Estimation from 10 cohort studies. Atherosclerosis, 262, 51-54. | 4 primary references | 2026 |
| Online Mental Health Treatment: What the Apps Can't Do A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Internal Medicine & Prevention) Online psychiatry services made starting medication easier than ever. A Philadelphia physician on what the subscription model misses, and why your body belongs in your mental health care. Primary anchor: Rush AJ, Trivedi MH, Wisniewski SR, et al. Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STARD report. American Journal of Psychiatry*. 2006;163(11):1905-1917. | 4 primary references | 2026 |
| Online Weight Loss Programs: What the Subscription Skips A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Internal Medicine & Prevention) Online GLP-1 programs are good at starting the prescription. A Philadelphia physician on what the subscription model leaves out, and what complete weight care looks like. Primary anchor: Wilding JPH, Batterham RL, Calanna S, et al. Once-Weekly Semaglutide in Adults with Overweight or Obesity (STEP 1). New England Journal of Medicine. 2021;384:989-1002. | 4 primary references | 2026 |
| PCOS: Its Metabolic, Not Just Hormonal A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Endocrinology & Reproductive Health) PCOS is often missed or masked with birth control. Dr. Ash treats the metabolic root cause, insulin resistance, to restore cycles, clear acne, and optimize fertility. Primary anchor: Dunaif A. "Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis." Endocrine Reviews. 1997;18(6):774-800. | 4 primary references | 2024 |
| PCSK9 Inhibitors (Repatha, Praluent): The Strongest LDL Drugs A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Preventive Cardiology & Lipids) PCSK9 inhibitors (Repatha, Praluent) lower LDL by 50 to 60% on top of a statin, the most of any drug class. What FOURIER, ODYSSEY, and the 2025 VESALIUS-CV trial proved, safety at very low LDL, dosing, and cost. Primary anchor: Sabatine MS, Giugliano RP, Keech AC, et al. "Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease." New England Journal of Medicine. 2017;376(18):1713-1722. | 4 primary references | 2026 |
| Pennsylvania CDL Self-Certification and the 45-Day Downgrade Clock A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Internal Medicine & Prevention) The 4 self-certification driving types, form DL-11CD, what changed June 23 2025, and how 45 days turns an expired medical card into a downgraded license. Primary anchor: Pennsylvania Department of Transportation. (2025). Self-Certification and Medical Examiner's Certification Frequently Asked Questions. Commercial Driver Information Center. | 4 primary references | 2026 |
| Pennsylvania's Medical Marijuana Program, Explained A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Therapeutics & Pharmacology) The qualifying conditions, the 4 steps in order, what it costs, which forms are legal, and what the law does and does not protect you from at work. Primary anchor: Medical Marijuana Act, Act 16 of 2016, 35 P.S. § 10231.101 et seq., as amended by Act 43 of 2018, Act 44 of 2021, and Act 63 of 2023. | 4 primary references | 2026 |
| Peptides: FDA-Approved Options A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) The FDA-approved peptide medications (GLP-1 receptor agonists, Tesamorelin) we prescribe, where compounded sermorelin fits, and why we don't prescribe research-grade peptides. Primary anchor: Wilding JPH, et al. "Once-weekly semaglutide in adults with overweight or obesity." NEJM. 2021. | 4 primary references | 2026 |
| PHGG: The Gentle Prebiotic Fiber A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Evidence-based guide to Partially Hydrolyzed Guar Gum (PHGG) in Philadelphia. Learn how this low-FODMAP prebiotic fiber supports regularity without gas or bloating. Primary anchor: Giannini, E. G., et al. (2006). Role of partially hydrolyzed guar gum in the treatment of irritable bowel syndrome. Nutrition, 22(3), 334-342. | 4 primary references | 2026 |
| Philly Fitness Guide: Strategies for Longevity A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) How to choose a training environment in Philadelphia that supports long-term health. A guide to heavy lifting, contrast therapy, and community. Primary anchor: Garcia-Hermoso A, et al. Muscular Strength as a Predictor of All-Cause Mortality in an Apparently Healthy Population. Archives of Physical Medicine and Rehabilitation. 2018;99(10):2100-2113. Evidence linking strength to lifespan. | 4 primary references | 2026 |
| Philly Flood Survival Kit A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Is your basement ready for the next Schuylkill surge? A Medicine 3.0 guide to flood safety, mold prevention, and protecting your health when the water comes in. Primary anchor: Centers for Disease Control and Prevention (CDC). Flood Safety and Hygiene. https://www.cdc.gov/disasters/floods/ | 4 primary references | 2024 |
| Philly Glovebox Survival Kit A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Driving in Philadelphia is a contact sport. A Medicine 3.0 guide to the mobile medical unit in your car, from tourniquets and aspirin to glass breakers for I-76 gridlock. Primary anchor: Kotwal RS, Butler FK, Gross KR, et al. "Management of Junctional Hemorrhage in Tactical Combat Casualty Care." Journal of Special Operations Medicine, 2013. | 4 primary references | 2024 |
| Philly Winter Survival Kit A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Is your row home ready for a power outage? A Medicine 3.0 guide to surviving a Philadelphia freeze with steady blood sugar, safe heat, and a watch on your neighbors. Primary anchor: Castellani JW, Young AJ, Ducharme MB, et al. "American College of Sports Medicine position stand: prevention of cold injuries during exercise." Medicine and Science in Sports and Exercise, 2006;38(11):2012-2029. | 4 primary references | 2024 |
| Phosphatidylcholine: Liquid Cellular Repair A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Evidence-based guide to Phosphatidylcholine (PC). A foundational tool for cell membrane fluidity, hepatic clearance, and cognitive focus. Primary anchor: Gundermann, K. J., et al. (2011). Essential phospholipids in fatty liver: a scientific update. Clinical and Experimental Gastroenterology, 4, 105-117. | 4 primary references | 2026 |
| Phosphatidylserine: Blunting the Cortisol Spike A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Why you feel 'Tired but Wired.' How Phosphatidylserine blunts the cortisol response and keeps aging brain cells fluid. Primary anchor: Hellhammer, J., et al. (2004). Effects of soy lecithin phosphatidic acid and phosphatidylserine complex (PAS) on the endocrine and psychological responses to mental stress. Stress, 7(2), 119-126. | 4 primary references | 2026 |
| Polymyalgia Rheumatica: Sudden Shoulder and Hip Stiffness A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) New shoulder and hip stiffness after 50 with a high CRP can be polymyalgia rheumatica. How it is diagnosed, its link to giant cell arteritis, and how it is treated. Primary anchor: Buttgereit F, Dejaco C, Matteson EL, Dasgupta B. "Polymyalgia Rheumatica and Giant Cell Arteritis: A Systematic Review." JAMA. 2016;315(22):2442-2458. | 4 primary references | 2026 |
| Potassium: The Blood Pressure Regulator A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Why Dr. Ash tests RBC potassium instead of trusting a 'normal' serum level, how potassium drives insulin sensitivity, and why 'eat more bananas' is bad advice. Primary anchor: Chatterjee, R., et al. (2011). Potassium and risk of type 2 diabetes. Expert Review of Endocrinology & Metabolism, 6(5), 665-672. | 4 primary references | 2026 |
| Precision Care Mapping: How We Build Your Personalized Health Strategy A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Health Systems & Clinical Communication) Discover how Fishtown Medicine creates data-driven, strategic health plans that move beyond generic templates to optimize your long-term healthspan. Primary anchor: Sniderman AD, et al. "Apolipoprotein B Particles and Cardiovascular Disease: A Narrative Review." JAMA Cardiology. 2019. | 4 primary references | 2026 |
| Precision Hormone Health: Beyond "Normal" A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Hormone optimization for men (TRT, fertility) and women (BHRT, menopause). A Philadelphia primary care practice using a precision, longevity-focused approach. Primary anchor: Bhasin S, et al. Testosterone Therapy in Men with Hypogonadism: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2018;103(5):1715-1744. | 4 primary references | 2026 |
| Precision Insight: Specialized Diagnostic Testing A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Health Systems & Clinical Communication) Move beyond standard labs. Learn how Fishtown Medicine uses specialty diagnostics like stool microbiome, advanced hormones, and micronutrient panels to find root causes. Primary anchor: Newman JC, et al. "Microbiome and Inflammation: From Mucosal Sentinel to Systemic Modulator." Annual Review of Pathology. 2022. | 4 primary references | 2026 |
| Precision Prevention: The Role of Genetic Testing A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Health Systems & Clinical Communication) Understand your blueprint. Learn how Fishtown Medicine uses advanced genetic testing to identify personal health risks and optimize your longevity strategy. Primary anchor: Mahley RW, Rall SC. "Apolipoprotein E: Far More Than a Lipid Transport Protein." Annual Review of Genomics and Human Genetics. 2000. | 4 primary references | 2026 |
| Precision Weight Loss: The GLP-1 & Metabolic Strategy A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Health Systems & Clinical Communication) Weight loss is not about willpower. Learn how Fishtown Medicine uses GLP-1 medications and muscle-preservation strategies for sustainable health. Primary anchor: Wilding JPH, et al. "Once-Weekly Semaglutide in Adults with Overweight or Obesity." New England Journal of Medicine. 2021. | 4 primary references | 2026 |
| Probiotics: Restoring the Ecosystem A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Evidence-based guide to probiotics. Why "more CFUs" is not better, and which specific strains work for IBS, antibiotics, and immunity. Primary anchor: Hill, C., et al. (2014). Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nature Reviews Gastroenterology & Hepatology, 11(8), 506-514. | 4 primary references | 2026 |
| Protecting Your Future Family A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Endocrinology & Reproductive Health) Dont wait for "infertility" to start thinking about fertility. Dr. Ash optimizes metabolic health, thyroid, and nutrient status to prepare your body for pregnancy. Primary anchor: Alexander EK, et al. "2017 Guidelines of the American Thyroid Association for the Diagnosis and Management of Thyroid Disease During Pregnancy and the Postpartum." Thyroid. 2017;27(3):315-389. | 4 primary references | 2024 |
| PSA and Prostate Screening: The Nuanced Decision A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Diagnostic Imaging & Biomarker Triage) The PSA test can catch prostate cancer early but also leads to overdiagnosis. Who should be screened, how modern MRI-first workups reduce harm, and how Fishtown Medicine approaches the decision in Philadelphia. Primary anchor: US Preventive Services Task Force. "Screening for Prostate Cancer: US Preventive Services Task Force Recommendation Statement." JAMA. 2018;319(18):1901-1913. | 4 primary references | 2026 |
| Quercetin: The Systemic Allergy Shield A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Evidence-based guide to quercetin. Why "stabilization" beats "blocking" for allergies. Case study: how Dr. Ash reversed his own cat allergy. Primary anchor: Mlcek, J., et al. (2016). Quercetin and its anti-allergic immune response. Molecules, 21(5), 623. | 4 primary references | 2026 |
| Rapamycin for Longevity: What's Proven and What Isn't A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Geroscience & Healthspan Medicine) Rapamycin extends lifespan in mice and has a plausible mechanism, but no human trial has shown it extends human life. a look at the evidence, the risks, off-label dosing, and how Fishtown Medicine approaches it in Philadelphia. Primary anchor: Harrison DE, Strong R, Sharp ZD, et al. "Rapamycin fed late in life extends lifespan in genetically heterogeneous mice." Nature. 2009;460(7253):392-395. | 4 primary references | 2026 |
| Reishi: The Anchor for the Wired Mind A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) For the "wired but tired" Philadelphian. How reishi (Ganoderma) works as a "digital sunset" for your nervous system. Primary anchor: Tang, W., et al. (2005). Ganoderma lucidum polysaccharide peptide reduced the production of proinflammatory cytokines in activated rheumatoid synovial fibroblast. Molecular Immunology, 42(3), 285-294. | 4 primary references | 2026 |
| Rhodiola: Botanical Stress Resilience A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Evidence-based guide to Rhodiola Rosea. Learn how to use this adaptogen for burnout, the importance of "Rosavins," and critical safety for bipolar disorder. Primary anchor: Panossian, A., & Wikman, G. (2010). Effects of adaptogens on the central nervous system and the molecular mechanisms associated with their stress-protective activity. Pharmaceuticals, 3(1), 188-224. | 4 primary references | 2026 |
| Saw Palmetto: Targeted Prostate Support A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Evidence-based guide to saw palmetto. Understanding the mechanism (5-alpha reductase inhibition), dosing (320 mg extract), and screening for BPH mimics. Primary anchor: Kwon, Y. (2019). Use of saw palmetto (Serenoa repens) extract for benign prostatic hyperplasia. Food Science and Biotechnology, 28(6), 1599-1606. | 4 primary references | 2026 |
| Seeing a Doctor Without Insurance in Philadelphia A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Internal Medicine & Prevention) What care costs in Philadelphia without insurance, urgent care and ER numbers included, and how a flat-fee membership with cash-pay labs compares. Primary anchor: Peterson-KFF Health System Tracker. (2022). Emergency room visits exceed affordability threshold for many people with private insurance. | 4 primary references | 2026 |
| Sleep Apnea in Fit Men A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Endocrinology & Reproductive Health) Why lean, fit men are often diagnosed with sleep apnea and how it lowers testosterone. The Medicine 3.0 approach to airway health and hormone recovery. Primary anchor: Santamaria JD, et al. "The effect of CPAP treatment on testosterone levels in men with obstructive sleep apnea." Sleep. 2012. | 4 primary references | 2026 |
| Sulforaphane: Turning On Your Defense Genes A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Why sulforaphane is the most potent natural Nrf2 activator: Phase II detox enzymes, broccoli sprouts vs. supplements, and the myrosinase question. Primary anchor: Fahey, J. W., et al. (1997). Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens. Proceedings of the National Academy of Sciences, 94(19), 10367-10372. | 4 primary references | 2026 |
| Supplement Exit Strategies: Why You Shouldn't Be on a Pill Forever A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) In Medicine 3.0, supplements are temporary 'bridges,' not lifetime subscriptions. Learn why Dr. Ash designs every strategy with a defined exit plan based on your data. Primary anchor: Mursu, J., et al. (2011). Dietary supplements and mortality rate in older women: the Iowa Women's Health Study. Archives of Internal Medicine, 171(18), 1625-1633. | 4 primary references | 2026 |
| Swollen Lymph Nodes: When to Watch and When to Act A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) Found a lump? Learn when swollen lymph nodes are a normal sign of immune activity and when they need a clinical evaluation. Primary anchor: Bazemore AW, Smucker DR. Lymphadenopathy and malignancy. Am Fam Physician. 2002;66(11):2103-2110. | 4 primary references | 2026 |
| Testing for Celiac After Going Gluten-Free A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) Celiac blood tests turn falsely negative once you stop eating gluten. Here's why, what a gluten challenge involves, and when it's fine not to test. Primary anchor: Rubio-Tapia A, et al. American College of Gastroenterology Guidelines Update: Diagnosis and Management of Celiac Disease. Am J Gastroenterol. 2023;118(1):59-76. | 4 primary references | 2026 |
| The 'Oatmeal Test': Why You Need a CGM Even If You Aren't Diabetic A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Go beyond HbA1c. Continuous Glucose Monitors (CGM) reveal your unique metabolic response to food. Learn how we use data to fix metabolism. Primary anchor: Hall H, et al. Glucotypes reveal new patterns of glucose dysregulation. PLOS Biology. 2018;16(7):e2005143. Classifying individuals into "glucotypes" using CGM data, revealing that "normal" people often have diabetic-level spikes. | 4 primary references | 2026 |
| The 'Widowmaker' Genetic Risk Factor A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Preventive Cardiology & Lipids) You can have normal LDL and still be at high risk for a heart attack. Dr. Ash tests for Lipoprotein(a), the genetic 'heart attack' marker that standard panels miss. Primary anchor: Kronenberg F, et al. "Lipoprotein(a) in atherosclerotic cardiovascular disease and aortic stenosis: a European Atherosclerosis Society consensus statement." European Heart Journal. 2022. | 4 primary references | 2024 |
| The "Greens Powder" Dilemma: Why Whole-Food Mimics Often Fail Your Labs A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Is your daily scoop moving the needle? Dr. Ash breaks down the math behind proprietary blends and why single-ingredient precision wins. Primary anchor: Lutsey, P. L., et al. (2020). "Prevalence and Trends of Vitamin D Deficiency in the US Population." The American Journal of Clinical Nutrition. | 4 primary references | 2026 |
| The 2026 Insurance Cliff A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Health Systems & Clinical Communication) Why your health insurance premiums just doubled, why the bronze plan is a trap, and how to opt out of the system before January 15th. Primary anchor: Eskew PM, Klink K. "Direct Primary Care: Practice Distribution and Cost Across the Nation." Journal of the American Board of Family Medicine. 2015. | 4 primary references | 2025 |
| The Advanced Tests Your Doctor Probably Isn't Ordering A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Diagnostic Imaging & Biomarker Triage) The standard annual panel misses the markers that predict heart disease, diabetes, and decline years early. The advanced tests worth asking for, what each one shows, and how Fishtown Medicine uses them in Philadelphia. Primary anchor: Sniderman AD, Thanassoulis G, Glavinovic T, et al. "Apolipoprotein B Particles and Cardiovascular Disease: A Narrative Review." JAMA Cardiology. 2019;4(12):1287-1295. | 4 primary references | 2026 |
| The Aging Parents Playbook A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Care Coordination & Preventive Protocols) A strategic guide for Philadelphia families on managing aging parents. Move from 'Crisis Management' to 'System Design' with this medical and legal roadmap. Primary anchor: American Geriatrics Society Beers Criteria Update Expert Panel. (2023). American Geriatrics Society 2023 updated AGS Beers Criteria for potentially inappropriate medication use in older adults. Journal of the American Geriatrics Society, 71(7), 2052-2081. | 4 primary references | 2024 |
| The CGM Guide: High-Resolution Metabolism A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Health Systems & Clinical Communication) CGMs aren't just for diabetes. Learn how Continuous Glucose Monitors help non-diabetics optimize energy, sleep, and long-term metabolic health. Primary anchor: Battelino T, et al. "Clinical Targets for Continuous Glucose Monitoring Data Interpretation." Diabetes Care. 2019. | 4 primary references | 2026 |
| The Complex Multisystem Care Strategy A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Care Coordination & Preventive Protocols) When the standard system says 'you're fine' but you know you're not. A home for the medical mystery and complex chronic conditions. Primary anchor: Naviaux, R. K. (2014). Metabolic features of the cell danger response. Mitochondrion, 16, 7-17. | 4 primary references | 2024 |
| The Complexity of Genetic Sex A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Health Systems & Clinical Communication) Biological sex is more than XX or XY. How Fishtown Medicine approaches genetic sex, chromosomes, and hormones with clinical precision and respect. Primary anchor: Sax L. "How common is intersex? A response to Anne Fausto-Sterling." Journal of Sex Research. 2002. | 4 primary references | 2026 |
| The Future of Medicine 3.0 A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Health Systems & Clinical Communication) We are at an inflection point. Discover the shift from analog 'sick care' to digital, predictive, and participatory health stewardship for a 100-year life. Primary anchor: Topol EJ. "High-performance medicine: the convergence of human and artificial intelligence." Nature Medicine. 2019. | 4 primary references | 2024 |
| The Informed Patient: A Guide to At-Home Health Monitoring A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Health Systems & Clinical Communication) Equip your home with the right tools. Learn which clinical devices Dr. Ash recommends for at-home monitoring and how to share your data for better care. Primary anchor: Stergiou GS, et al. "Home blood pressure monitoring: methodology, clinical relevance and practical application: a 2021 position paper by the Working Group on Blood Pressure Monitoring and Cardiovascular Variability of the European Society of Hypertension." Journal of Hypertension. 2021. | 4 primary references | 2026 |
| The Metabolic Engine: Understanding Insulin Resistance A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Health Systems & Clinical Communication) Is your metabolism stalled? Learn what insulin resistance is, how it drives chronic disease, and how we fix it at Fishtown Medicine. Primary anchor: Reaven GM. "Banting Lecture 1988. Role of insulin resistance in human disease." Diabetes. 1988. | 4 primary references | 2026 |
| The Metabolic Thermostat: Thyroid Optimization Strategy A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Health Systems & Clinical Communication) Is your thyroid 'Normal' but you still feel tired? Learn how Fishtown Medicine uses the Chicago Consensus to optimize thyroid function beyond standard lab ranges. Primary anchor: Jonklaas J, et al. "Guidelines for the Treatment of Hypothyroidism." Thyroid. 2014. | 4 primary references | 2026 |
| The Missing Horseman: Why Road Safety is the Ultimate Longevity Strategy A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) The number one cause of death for people under 45 is not cancer or heart disease. It is accidental injury. How to prevent the unforced error in your longevity plan. Primary anchor: CDC WONDER. Leading Causes of Death Reports, 1981-2022. Centers for Disease Control and Prevention. Confirms unintentional injury as the leading cause of death for ages 1 to 44. | 4 primary references | 2026 |
| The Neck Lump That Comes and Goes A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Differential Diagnosis & Internal Medicine) A neck lump that swells after eating or stress and shrinks overnight usually isn't a tumor. Learn what it can be and when ultrasound gives the answer. Primary anchor: Gaddey HL, Riegel AM. Unexplained Lymphadenopathy: Evaluation and Differential Diagnosis. Am Fam Physician. 2016;94(11):896-903. | 4 primary references | 2026 |
| The Neighbor's Health Playbook A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Care Coordination & Preventive Protocols) For the clinical partner and the community neighbor. How to automate your health, fight sedentary risks, and optimize energy for work and family. Primary anchor: Hamilton, M. T., Hamilton, D. G., & Zderic, T. W. (2007). Role of low energy expenditure and sitting in obesity, metabolic syndrome, type 2 diabetes, and cardiovascular disease. Diabetes, 56(11), 2655-2667. | 4 primary references | 2026 |
| The Philadelphia Foodshed as a Clinical Asset: A Definitive Guide to Local Sourcing A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) A guide to sourcing nutrient-dense, local food in Philadelphia for better metabolic health: CSAs, ethical butchers, and sustainable seafood with the logistics. Primary anchor: Barrett DM. Maximizing the nutritional value of fruits and vegetables. Food Technology. 2007;61(4):40-44. Discussion of nutrient loss after harvest. | 4 primary references | 2026 |
| The Power of Proximity: Why Relationship-Based Medicine Matters A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Health Systems & Clinical Communication) Discover the value of a long-term, direct relationship with your physician. Learn how Fishtown Medicine returns to an 'old school' model of care. Primary anchor: Pereira Gray DJ, et al. "Continuity of care with doctors, a matter of life and death? A systematic review of continuity of care and mortality." BMJ Open. 2018. | 4 primary references | 2026 |
| The Problem with the 'Mix': Why Simplicity is Safer A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) The clinical reasoning behind why we avoid 'sleep blends,' 'greens powders,' and 'proprietary mixes.' Why single-ingredient precision yields better data and safer care. Primary anchor: Navarro, V. J., et al. (2017). Liver injury from herbal and dietary supplements. Hepatology, 65(1), 363-373. | 4 primary references | 2026 |
| The Roadmap: Your Initial Diagnostic Evaluation A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Health Systems & Clinical Communication) Start your journey with precision. Learn what to expect during your first 90 days at Fishtown Medicine, from deep-dive consults to advanced lab reviews. Primary anchor: Sniderman AD, et al. "Apolipoprotein B Particles and Cardiovascular Disease: A Narrative Review." JAMA Cardiology. 2019. | 4 primary references | 2026 |
| The Safety Seal Audit: NSF, cGMP, and How to Spot Professional-Grade Supplements A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) The supplement industry is unregulated. Dr. Ash explains how to read labels, verify NSF and cGMP testing, and pick safe, professional-grade supplements. Primary anchor: Cohen, P. A., et al. (2018). "Presence of Banned Drugs in Dietary Supplements Following FDA Recalls." JAMA Internal Medicine, 174(10), 1668-1669. | 4 primary references | 2026 |
| The Shingles Vaccine and Dementia: What the Evidence Shows A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Geroscience & Healthspan Medicine) Multiple strong studies link the shingles vaccine (Shingrix) to lower dementia risk. What the Welsh natural experiment and the Shingrix data show, the leading theories, and the limits of the evidence. Primary anchor: Eyting M, Xie M, Michalik F, et al. "A natural experiment on the effect of herpes zoster vaccination on dementia." Nature. 2025;641(8062):438-446. | 4 primary references | 2026 |
| The Snow Didn't Kill Them | Snow Shoveling and Heart Attack Risk A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Why shoveling is the ultimate cardiac stress test, and why the 'widowmaker' heart attack starts in your 20s. A guide. Primary anchor: Janardhanan R, et al. "Snow shoveling and the risk of acute coronary syndromes." Clinical Research in Cardiology, 2010. | 4 primary references | 2026 |
| The Two Best Predictors of Longevity: VO2 Max and Muscle Mass A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Cardiorespiratory fitness and muscle mass are two of the strongest predictors of how long and how well you live. A Medicine 3.0 approach in Philadelphia. Primary anchor: Mandsager K, et al. Association of cardiorespiratory fitness with long-term mortality among adults undergoing exercise treadmill testing. JAMA Netw Open. 2018;1(6):e183605. | 4 primary references | 2026 |
| Thyroid Optimization A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Endocrinology & Reproductive Health) Many patients are told their thyroid is normal when it is not. Learn the difference between lab normal and biological optimal, and the role of T3 in metabolism. Primary anchor: Jonklaas J, Bianco AC, et al. Evidence-Based Use of Levothyroxine/Liothyronine Combinations in Treating Hypothyroidism: A Consensus Document. Thyroid. 2021;31(2):156-182. | 4 primary references | 2026 |
| Tonsil Stones: The Root Cause Fix A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Evidence-based guide to resolving recurrent tonsil stones in adults using BLIS K12 probiotics, dairy elimination, and gentle mechanical hygiene. Primary anchor: Burton, J. P., et al. (2006). "A preliminary study of the effect of probiotic Streptococcus salivarius K12 on oral malodour parameters." Journal of Applied Microbiology. | 4 primary references | 2024 |
| Trauma-Informed & Judgment-Free Care A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Health Systems & Clinical Communication) Your history matters. Learn how Fishtown Medicine practices trauma-informed medicine to create a safe, respectful, and shaming-free environment for your health journey. Primary anchor: Substance Abuse and Mental Health Services Administration (SAMHSA). "Concept of Trauma and Guidance for a Trauma-Informed Approach." 2014. | 4 primary references | 2026 |
| TRT vs. Enclomiphene: Keeping Your Edge A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Endocrinology & Reproductive Health) Choosing between testosterone replacement (TRT) and enclomiphene citrate. Dr. Ash explains the fertility trade-offs, side effects, and clinical outcomes. Primary anchor: Wiehle RD, et al. (2014). "Enclomiphene citrate stimulates serum testosterone in men with secondary hypogonadism under restoration of sperm counts." Fertility and Sterility, 102(3), 720-727. | 4 primary references | 2026 |
| TRT: The Modern Safety Data A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Endocrinology & Reproductive Health) The heart attack myth has been put to rest. Learn the TRAVERSE trial safety data and the Medicine 3.0 approach to optimizing male hormones. Primary anchor: Lincoff AM, Bhasin S, et al. Cardiovascular Safety of Testosterone-Replacement Therapy. N Engl J Med. 2023;389:107-117. (The TRAVERSE Trial). | 4 primary references | 2026 |
| Ultra-Processed Food: What It Does to Your Health A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Metabolic Medicine & Bioenergetics) Ultra-processed foods make up most of the American diet and are tied to weight gain, diabetes, and heart disease. What counts as ultra-processed, why it overrides your appetite, and how Fishtown Medicine helps you cut it in Philadelphia. Primary anchor: Hall KD, Ayuketah A, Brychta R, et al. "Ultra-Processed Diets Cause Excess Calorie Intake and Weight Gain: An Inpatient Randomized Controlled Trial of Ad Libitum Food Intake." Cell Metabolism. 2019;30(1):67-77. | 4 primary references | 2026 |
| Understanding Brain & Head Imaging A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Diagnostic Imaging & Biomarker Triage) Headaches, dizziness, or neuro changes? Learn about CT scans, MRIs, and MRAs, and how Dr. Ash determines the right imaging strategy for your brain health. Primary anchor: Powers WJ, et al. "Guidelines for the Early Management of Patients with Acute Ischemic Stroke." Stroke. 2019. | 4 primary references | 2026 |
| Understanding Your Scores: PHQ-9, GAD-7, and ASRS A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) What those numbers mean. A transparent guide to how we track depression, anxiety, and ADHD signals over time. Primary anchor: Kroenke K, Spitzer RL, Williams JBW. The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med. 2001;16(9):606-613. | 4 primary references | 2026 |
| Valerian: A Calm-Down Aid for Racing Minds A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Evidence-based guide to Valerian Root. Learn how to use it for racing minds, why the smell is normal, and how to stay safe with sedatives. Primary anchor: Bent, S., et al. (2006). "Valerian for sleep: a systematic review and meta-analysis." American Journal of Medicine, 119(12), 1005-1012. | 4 primary references | 2026 |
| Vitamin D3 + K2: A Strategic Pair A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Why taking Vitamin D without K2 is incomplete, and how to keep calcium in your bones instead of your arteries. Primary anchor: Holick, M. F., et al. (2011). Evaluation, Treatment, and Prevention of Vitamin D Deficiency: an Endocrine Society Clinical Practice Guideline. Journal of Clinical Endocrinology & Metabolism, 96(7), 1911-1930. | 4 primary references | 2025 |
| Vitamin D3: The Stewardship of a Hormone A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Why the standard 50,000 IU green capsule (D2) fails, why you need K2, and how to survive a Philadelphia winter. Primary anchor: Holick, M. F., et al. (2011). Evaluation, Treatment, and Prevention of Vitamin D Deficiency: an Endocrine Society Clinical Practice Guideline. Journal of Clinical Endocrinology & Metabolism, 96(7), 1911-1930. | 4 primary references | 2026 |
| What Adult ADHD Care Costs A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) What an adult ADHD evaluation and treatment cost in Philadelphia, a comparison of the fast-online, psychiatrist-referral, and physician-led models, and why the cheapest option is often the most expensive in the end. From Fishtown Medicine. Primary anchor: Faraone SV, et al. The World Federation of ADHD International Consensus Statement: 208 evidence-based conclusions about the disorder. Neurosci Biobehav Rev. 2021;128:789-818. | 4 primary references | 2026 |
| What Your Blood Count Reveals A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Diagnostic Imaging & Biomarker Triage) A routine CBC carries quiet signals about inflammation and stress load that most reports skip past. How to read the neutrophil-to-lymphocyte ratio, the cortisol pattern, and what a basic panel leaves out. Primary anchor: Zahorec R. "Neutrophil-to-lymphocyte ratio, past, present and future perspectives." Bratislava Medical Journal. 2021;122(7):474-488. | 4 primary references | 2026 |
| When Your Labs Are 'Normal' but You Feel Sick A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Health Systems & Clinical Communication) A normal lab result is not the same as a normal person. Why you can feel awful with results inside the reference range, what "normal" measures, and how to get a deeper look, from Fishtown Medicine in Philadelphia. Primary anchor: Clinical and Laboratory Standards Institute. "Defining, Establishing, and Verifying Reference Intervals in the Clinical Laboratory; Approved Guideline." CLSI document EP28-A3c. 2010. (Reference intervals are defined as the central 95% of values in a healthy reference population.) | 4 primary references | 2026 |
| Why We Pause DIM Before Hormone Labs A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Endocrinology & Reproductive Health) DIM and sulforaphane change how your body handles estrogen, which can blur a hormone panel. Here's why we pause them before testing and for how long. Primary anchor: Thomson CA, et al. Chemopreventive properties of 3,3'-diindolylmethane in breast cancer: evidence from experimental and human studies. Nutr Rev. 2016;74(7):432-443. | 4 primary references | 2026 |
| Women's Preventive Imaging Guide A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Diagnostic Imaging & Biomarker Triage) Mammograms, Breast MRIs, and Bone Density scans. Learn about the essential preventive imaging for women and how Fishtown Medicine personalizes your screening timeline. Primary anchor: Monticciolo DL, et al. "Breast Cancer Screening for Women at Higher-Than-Average Risk." Journal of the American College of Radiology. 2018. | 4 primary references | 2026 |
| Your IgM Came Back Low: What It Means A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) A low IgM can mean selective IgM deficiency, a subtle immune finding. What IgM does, what a low level means, its causes, and the workup it deserves. Primary anchor: Gupta S, Gupta A. "Selective IgM Deficiency-An Underestimated Primary Immunodeficiency." Frontiers in Immunology. 2017;8:1056. | 4 primary references | 2026 |
| Zinc Needs Copper: Supplement Stewardship A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Health Systems & Clinical Communication) Long-term zinc without copper can cause deficiency, and daily high-dose vitamin C isn't free of trade-offs. How to supplement deliberately, not forever. Primary anchor: Duncan A, et al. The risk of copper deficiency in patients prescribed zinc supplements. J Clin Pathol. 2015;68(9):723-725. | 4 primary references | 2026 |
| 2026 Sports Health Guide A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Internal Medicine & Prevention) Your healthcare guide for the FIFA World Cup, MLB All-Star Game, NCAA March Madness, and PGA Championship in Philadelphia. Skip the ER and enjoy the games. Primary anchor: CDC. (2024). Heat-Related Illness Resources for the Public. | 3 primary references | 2026 |
| Alcohol and Longevity: What the Evidence Now Says A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Geroscience & Healthspan Medicine) The "moderate drinking is healthy" story has fallen apart. What the current evidence shows about alcohol, cancer, heart, and metabolism, and how Fishtown Medicine helps you think about your own risk without judgment in Philadelphia. Primary anchor: GBD 2016 Alcohol Collaborators. "Alcohol use and burden for 195 countries and territories, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016." Lancet. 2018;392(10152):1015-1035. | 3 primary references | 2026 |
| Algae Oil: The Plant-Based Omega-3 A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Evidence-based guide to Algae Oil supplementation in Philadelphia. Learn why Algae Oil is a sustainable, fish-free source of bio-identical EPA and DHA. Primary anchor: Lane K, et al. "Bioavailability and potential uses of vegetarian sources of omega-3 fatty acids: a review of the literature." Critical Reviews in Food Science and Nutrition. 2014;54(5):572-579. | 3 primary references | 2026 |
| An Alternative to Done ADHD A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Looking for an alternative to Done ADHD? If your online ADHD service closed or you want care that is more than an auto-refill, here is what a responsible adult ADHD evaluation and treatment plan looks like, and how to move your care safely. Primary anchor: American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 5th ed, Text Revision (DSM-5-TR). 2022. | 3 primary references | 2026 |
| Ashwagandha: Managing the Stress Signal A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Evidence-based guide to Ashwagandha (KSM-66 & Sensoril). Learn safe dosing for anxiety, sleep quality, and cortisol regulation from a Philadelphia physician. Primary anchor: Chandrasekhar K, et al. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian J Psychol Med. 2012. | 3 primary references | 2024 |
| B-Complex: The Metabolic Spark Plug A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Evidence-based guide to Methylated B-Complex. Learn why 'tissue-ready' forms (5-MTHF, P-5-P) are critical for MTHFR, cellular energy, and crushing fatigue. Primary anchor: Kennedy DO. B Vitamins and the Brain: Mechanisms, Dose and Efficacy, A Review. Nutrients. 2016. | 3 primary references | 2024 |
| Bempedoic Acid (Nexletol): When Statins Are Not an Option A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Preventive Cardiology & Lipids) Bempedoic acid (Nexletol) lowers LDL cholesterol for people who cannot tolerate statins, and rarely causes muscle aches. What the CLEAR Outcomes trial showed, how much it lowers cholesterol, and its gout and tendon cautions. Primary anchor: Nissen SE, Lincoff AM, Brennan D, et al. "Bempedoic Acid and Cardiovascular Outcomes in Statin-Intolerant Patients." New England Journal of Medicine. 2023;388(15):1353-1364. | 3 primary references | 2026 |
| Berberine: A Potent Metabolic Regulator A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Evidence-based guide to Berberine (HCl & Phytosome). Learn why it is a critical tool for blood sugar, cholesterol, and PCOS management. Primary anchor: Zhang Y, et al. Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. J Clin Endocrinol Metab. 2008. | 3 primary references | 2024 |
| Body Composition Testing: DEXA vs InBody vs BodPod A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Diagnostic Imaging & Biomarker Triage) Weight and BMI miss what matters: fat, muscle, and where the fat is stored. How the main body composition tests compare, which one to get for which goal, and how Fishtown Medicine uses them in Philadelphia. Primary anchor: Neeland IJ, Ross R, Després JP, et al. "Visceral and ectopic fat, atherosclerosis, and cardiometabolic disease: a position statement." The Lancet Diabetes & Endocrinology. 2019;7(9):715-725. | 3 primary references | 2026 |
| Boswellia: The Non-NSAID Joint Tool A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Evidence-based guide to Boswellia serrata (frankincense). How AKBA and 5-LOX inhibition ease osteoarthritis pain without the gut risk of NSAIDs. Primary anchor: Kimmatkar N, Thawani V, Hingorani L, Khiyani R. Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee: a randomized double blind placebo controlled trial. Phytomedicine. 2003;10(1):3-7. | 3 primary references | 2026 |
| Brain Fog: It's Not Aging. It's a Signal. A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Brain fog is almost never early dementia. It's usually 4 fixable drivers: glucose swings, sleep debt, hormones, and inflammation. Primary anchor: Xie L, et al. Sleep drives metabolite clearance from the adult brain. Science. 2013;342(6156):373-377. | 3 primary references | 2026 |
| Care Playbooks A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Care Coordination & Preventive Protocols) custom healthcare pathways for your specific needs. Primary anchor: American Academy of Family Physicians. (2023). Direct Primary Care: An Alternative Practice Model. | 3 primary references | 2026 |
| Chamomile: More Than Just Tea A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Evidence-based guide to Chamomile and its active compound Apigenin. Learn why it rivals prescription anxiolytics for increasing GABA and calming the nervous system. Primary anchor: Amsterdam, J. D., et al. (2009). "A randomized, double-blind, placebo-controlled trial of oral Matricaria recutita (chamomile) extract therapy for generalized anxiety disorder." Journal of Clinical Psychopharmacology, 29(4), 378-382. | 3 primary references | 2024 |
| Citicoline: Fuel for Brain Membranes A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Evidence-based guide to citicoline (CDP-choline). How it supports attention, memory, and vascular cognitive health, and where the evidence is thin. Primary anchor: Fioravanti M, Yanagi M. Cytidinediphosphocholine (CDP-choline) for cognitive and behavioural disturbances associated with chronic cerebral disorders in the elderly. Cochrane Database Syst Rev. 2005;(2):CD000269. | 3 primary references | 2026 |
| Clinical Independence & Transparency A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Health Systems & Clinical Communication) How Dr. Ash ensures your care remains independent and free from commercial conflicts. Primary anchor: Wazana A. "Physicians and the pharmaceutical industry: is a gift ever just a gift?" JAMA. 2000. | 3 primary references | 2026 |
| Clinical Supplement Guides A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Cutting through the noise of the supplement industry with clinical precision and personalized data. Primary anchor: Manson, J. E., et al. (2019). "Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease." New England Journal of Medicine, 380(1), 33-44. | 3 primary references | 2026 |
| Concierge vs. DPC: Which Fits You? A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Internal Medicine & Prevention) Concierge medicine bills insurance plus a $2,000+ yearly fee. Direct primary care replaces it with one flat rate. Dr. Ash compares cost, access, and results in Philadelphia. Primary anchor: Eskew PM, Klink K. Direct Primary Care: Practice Distribution and Cost Across the Nation. J Am Board Fam Med. 2015. | 3 primary references | 2026 |
| COVID-19 (2025): The "Razor Blade" Throat A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Internal Medicine & Prevention) The XEC and Nimbus variants are different. Why your rapid test is negative, why your throat feels like glass, and the new rules for Paxlovid. Primary anchor: Hammond J, et al. Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with Covid-19. N Engl J Med. 2022. | 3 primary references | 2024 |
| Direct Primary Care in Philadelphia A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Internal Medicine & Prevention) Direct primary care in Philadelphia: what DPC membership costs, how same-day access works, how insurance and HSA/FSA fit, and who the model is built for. Primary anchor: Eskew PM, Klink K. Direct Primary Care: Practice Distribution and Cost Across the Nation. J Am Board Fam Med. 2015. | 3 primary references | 2026 |
| Ezetimibe (Zetia): The Simple LDL-Lowering Add-On A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Preventive Cardiology & Lipids) Ezetimibe (Zetia) blocks cholesterol absorption in the gut to lower LDL and apoB. What the IMPROVE-IT trial proved, how it pairs with statins and bempedoic acid, its near-placebo safety, and the limits of its modest benefit. Primary anchor: Cannon CP, Blazing MA, Giugliano RP, et al. "Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes." New England Journal of Medicine. 2015;372(25):2387-2397. | 3 primary references | 2026 |
| Flu Season 2025: The "High Severity" Strain A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Internal Medicine & Prevention) This is the worst flu season since 2017. Learn why H3N2 is hitting harder, how to use the single-dose Xofluza, and why the 48-hour window matters. Primary anchor: Hayden FG, et al. Baloxavir Marboxil for Uncomplicated Influenza in Adults and Adolescents. N Engl J Med. 2018. | 3 primary references | 2024 |
| Functional Medicine: Finding the Root Cause A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Internal Medicine & Prevention) Looking for a functional medicine doctor in Philadelphia? Don't settle for 'magic supplements.' Discover the Medicine 3.0 approach that combines systems biol... Primary anchor: Sniderman AD, et al. Apolipoprotein B Particles and Cardiovascular Disease. JAMA Cardiol. 2019. | 3 primary references | 2024 |
| Getting Started: Your Onboarding Roadmap A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Health Systems & Clinical Communication) The onboarding roadmap at Fishtown Medicine: the task list you and Dr. Ash work through together, from consent and records to labs and the first 90 days. Primary anchor: Bodenheimer T, Pham HH. Primary Care: Current Problems and Proposed Solutions. Health Aff (Millwood). 2010;29(5):799-805. | 3 primary references | 2026 |
| GLP-1 Microdosing: What It Is and Whether It's Worth It A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Metabolic Medicine & Bioenergetics) GLP-1 microdosing uses lower-than-standard doses for metabolic and longevity goals rather than maximum weight loss. What the evidence does and doesn't show, who it might fit, and how Fishtown Medicine approaches it in Philadelphia. Primary anchor: Lincoff AM, Brown-Frandsen K, Colhoun HM, et al. "Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes." New England Journal of Medicine. 2023;389(24):2221-2232. | 3 primary references | 2026 |
| Graduate Hospital Adjacent. Proactive Health. A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Internal Medicine & Prevention) Connecting Graduate Hospital to the River. SW Center City gets modern, accessible primary care. Primary anchor: Sniderman, A. D., et al. (2019). Apolipoprotein B Particles and Cardiovascular Disease: A Narrative Review. JAMA Cardiology, 4(12), 1287-1295. | 3 primary references | 2026 |
| Healthspan Doctor in Philadelphia A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Internal Medicine & Prevention) What a healthspan doctor in Philadelphia does, the labs that matter, how it differs from longevity clinics, and how to tell substance from theater. Primary anchor: Sniderman, A. D., et al. (2019). Apolipoprotein B Particles and Cardiovascular Disease: A Narrative Review. JAMA Cardiology, 4(12), 1287-1295. | 3 primary references | 2026 |
| Healthspan Optimization: Living Better, Longer A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Internal Medicine & Prevention) Evidence-based healthspan optimization in Philadelphia (Fishtown and Center City): advanced diagnostics like ApoB, CAC, and VO2 max to extend the years you live in good health. Primary anchor: Sniderman AD, et al. Apolipoprotein B Particles and Cardiovascular Disease. JAMA Cardiol. 2019. | 3 primary references | 2026 |
| High Uric Acid: More Than Just Gout A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Metabolic Medicine & Bioenergetics) High uric acid causes gout, but it is also a marker of metabolic trouble tied to insulin resistance, high blood pressure, and fatty liver. What drives it, what the number means, and how Fishtown Medicine reads it in Philadelphia. Primary anchor: Johnson RJ, Nakagawa T, Sanchez-Lozada LG, et al. "Sugar, uric acid, and the etiology of diabetes and obesity." Diabetes. 2013;62(10):3307-3315. | 3 primary references | 2026 |
| Historic Elegance Meets Modern Medicine A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Internal Medicine & Prevention) Society Hill: colonial cobblestones and meticulous preservation. Your health deserves the same attention to detail. Primary anchor: Sniderman, A. D., et al. (2019). Apolipoprotein B Particles and Cardiovascular Disease: A Narrative Review. JAMA Cardiology, 4(12), 1287-1295. | 3 primary references | 2026 |
| Hospitalization Support: What Happens If I Go to the ER? A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Health Systems & Clinical Communication) We are your digital quarterback. How Fishtown Medicine coordinates your care when you are admitted to the hospital. Primary anchor: Jencks SF, et al. Rehospitalizations among Patients in the Medicare Fee-for-Service Program. N Engl J Med. 2009;360(14):1418-1428. | 3 primary references | 2026 |
| HRV and Resting Heart Rate: What They Really Mean A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Exercise Physiology & Cardiorespiratory Fitness) Heart rate variability and resting heart rate are two of the most useful numbers on your Oura or Whoop. What they mean, why trends beat single readings, and how Fishtown Medicine uses them in a longevity plan in Philadelphia. Primary anchor: Dekker JM, Crow RS, Folsom AR, et al. "Low Heart Rate Variability in a 2-Minute Rhythm Strip Predicts Risk of Coronary Heart Disease and Mortality From Several Causes: The ARIC Study." Circulation. 2000;102(11):1239-1244. | 3 primary references | 2026 |
| HSA Guide: Paying for DPC A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Health Systems & Clinical Communication) How to use your pre-tax Health Savings Account dollars to pay for your Fishtown Medicine membership and advanced diagnostics. Primary anchor: Internal Revenue Service. Publication 502: Medical and Dental Expenses. (Updated annually.) | 3 primary references | 2026 |
| Insurance & Benefits Guide: The Hybrid Model Explained A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Health Systems & Clinical Communication) Confused about Out-of-Network vs. DPC? Learn how Fishtown Medicine uses a 'Hybrid Model' to maximize your benefits for labs and imaging while keeping care personal. Primary anchor: Cole ES, et al. Direct Primary Care: Applying Theory to Potential Changes in Delivery and Outcomes. J Am Board Fam Med. 2018;31(4):605-611. | 3 primary references | 2026 |
| Is Concierge Medicine Worth It? A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Internal Medicine & Prevention) Concierge medicine in Philadelphia runs $1,800 to $28,000 a year in 2026. What each tier includes, and when paying for a membership doctor is worth it. Primary anchor: Klemes A, et al. Personalized preventive care reduces hospitalization rates. Am J Manag Care. 2012. | 3 primary references | 2026 |
| Is TRT Safe? The Cardiovascular Truth A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Endocrinology & Reproductive Health) Worried about heart attack or stroke on TRT? Dr. Ash explains the science of TRT safety, the difference between optimization and abuse, and how we monitor your heart. Primary anchor: TRAVERSE Trial: Lincoff AM, et al. (2023). "Cardiovascular Safety of Testosterone-Replacement Therapy." The New England Journal of Medicine, 389(2), 107-119. | 3 primary references | 2026 |
| L-Theanine: Calm Without Sedation A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) L-theanine dosing (100-400 mg), pairing it with caffeine, what it does for sleep and stress, and who should skip it. A physician's working guide. Primary anchor: Hidese S, Ogawa S, Ota M, et al. Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial. Nutrients. 2019;11(10):2362. | 3 primary references | 2026 |
| Making Labs and Imaging Affordable A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Health Systems & Clinical Communication) Cash-pay lab pricing is often a fraction of the billed rate, and the receipt can count toward your deductible. Here's how it works at Fishtown Medicine. Primary anchor: Robinson JC, Whaley C, Brown TT. Association of Reference Pricing with Prices, Use, and Spending for Laboratory Tests. N Engl J Med. 2016;374(11):1027-1035. | 3 primary references | 2026 |
| Medicine at Your Doorstep A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Health Systems & Clinical Communication) Experience physician-led care in your own environment. Home visits are included with your Fishtown Medicine membership across the Greater Philadelphia area. Primary anchor: Stall N, et al. Systematic review of outcomes from home-based primary care programs for homebound older adults. J Am Geriatr Soc. 2014;62(12):2243-2251. | 3 primary references | 2026 |
| Meet Dr. Ash A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Health Systems & Clinical Communication) Meet Ashvin Vijayakumar MD (Dr. Ash), the board-certified internist behind Philadelphia's best primary care - 4.96★ across 124+ verified reviews. Primary anchor: Attia P. Outlive: The Science and Art of Longevity. Harmony Books; 2023. | 3 primary references | 2026 |
| Menopause Care for the Modern Woman A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Endocrinology & Reproductive Health) From fertility prep to the menopause transition. Dr. Ash provides nuanced hormone care, PCOS management, and fertility-supportive primary care. Primary anchor: The NAMS 2022 Hormone Therapy Position Statement Advisory Panel. (2022). The 2022 hormone therapy position statement of The North American Menopause Society. Menopause, 29(7), 767-794. | 3 primary references | 2026 |
| Migraine vs. Tension vs. Cluster Headache A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Migraine, tension-type, and cluster headaches feel different and need different treatment. How to tell them apart by location, quality, duration, and the symptoms around them, the red flags that mean see someone now, and how we sort it out, from Fishtown Medicine in Philadelphia. Primary anchor: Headache Classification Committee of the International Headache Society (IHS). The International Classification of Headache Disorders, 3rd edition (ICHD-3). Cephalalgia. 2018;38(1):1-211. | 3 primary references | 2026 |
| MLB All-Star Health Guide A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Internal Medicine & Prevention) Heading to the Midsummer Classic at Citizens Bank Park? Beat the heat. Text Dr. Ash for urgent care house calls at your hotel. Skip the ER. Primary anchor: CDC. (2023). Heat-Related Illness: Information for Healthcare Professionals. | 3 primary references | 2026 |
| NAD+, NMN, and NR: Do the Supplements Work? A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Geroscience & Healthspan Medicine) NMN and NR supplements reliably raise NAD+ in humans, but whether that makes you healthier or longer-lived is unproven. What the evidence shows, the safety picture, and how Fishtown Medicine weighs NAD boosters in Philadelphia. Primary anchor: Martens CR, Denman BA, Mazzo MR, et al. "Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults." Nature Communications. 2018;9(1):1286. | 3 primary references | 2026 |
| NCAA Tournament Health Guide A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Internal Medicine & Prevention) Heading to the Xfinity Center for March Madness? Text Dr. Ash for urgent care house calls. Skip the ER and get back to the games. Primary anchor: CDC. (2024). Influenza (Flu) Prevention and Treatment. Centers for Disease Control and Prevention. | 3 primary references | 2026 |
| Ninth Street Internal Medicine has Closed A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Ninth Street Internal Medicine closed March 3, 2026. Where the providers went, what to do with your records, and how to find stable primary care in Philadelphia. Primary anchor: Bodenheimer T, Sinsky C. From Triple to Quadruple Aim: Care of the Patient Requires Care of the Provider. Annals of Family Medicine. 2014. On the systemic pressures that drive primary care burnout and turnover. | 3 primary references | 2026 |
| Norovirus Alert: Staying Well A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Internal Medicine & Prevention) It feels like dying. Here is how to survive the 24-hour storm, when to go to the ER, and why you need Zofran immediately. Primary anchor: Hall AJ, et al. Norovirus Disease in the United States. Emerg Infect Dis. 2013. | 3 primary references | 2024 |
| October in Philly: A Doctor's Guide to the Month A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) A Philadelphia doctor's guide to October: using HSA and FSA dollars before they vanish, the basics that carry you through cold season, and sorting the nagging thing before the holidays crowd it out. Primary anchor: Prather, A. A., Janicki-Deverts, D., Hall, M. H., & Cohen, S. (2015). Behaviorally assessed sleep and susceptibility to the common cold. Sleep, 38(9), 1353-1359. | 3 primary references | 2026 |
| Orforglipron (Foundayo): The GLP-1 Weight-Loss Pill A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Metabolic Medicine & Bioenergetics) Orforglipron (Foundayo) is the first oral small-molecule GLP-1 pill, approved for weight loss in 2026. How it differs from Rybelsus and the injectables, what the ATTAIN and ACHIEVE trials showed, and the convenience-versus-potency trade-off. Primary anchor: Wharton S, et al. "Daily Oral GLP-1 Receptor Agonist Orforglipron for Adults with Obesity." New England Journal of Medicine. 2023. | 3 primary references | 2026 |
| PGA Championship Health Guide A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Internal Medicine & Prevention) Attending the PGA Championship at Aronimink? Text Dr. Ash for discreet, top-tier medical care. Concierge service for executives and golf fans. Primary anchor: American Academy of Allergy, Asthma & Immunology. (2024). Pollen Counts and Allergy Forecast Guidelines. | 3 primary references | 2026 |
| Primary Care Physician in Philadelphia A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Internal Medicine & Prevention) Primary care physician in Philadelphia accepting new patients. Same-day access, 60-90 minute visits, a doctor you text directly. Rated 4.96 stars. Primary anchor: Pereira Gray, D. J., Sidaway-Lee, K., White, E., Thorne, A., & Evans, P. H. (2018). Continuity of care with doctors - a matter of life and death? A systematic review of continuity of care and mortality. BMJ Open, 8(6), e021161. | 3 primary references | 2026 |
| Retatrutide: The Triple-Agonist Weight-Loss Drug A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Metabolic Medicine & Bioenergetics) Retatrutide is Eli Lilly's investigational triple agonist (GIP, GLP-1, glucagon). What the phase 2 and phase 3 trials show for weight, diabetes, and liver fat, the glucagon heart-rate trade-off, and its investigational status. Primary anchor: Jastreboff AM, et al. "Triple-Hormone-Receptor Agonist Retatrutide for Obesity - A Phase 2 Trial." New England Journal of Medicine. 2023;389(6):514-526. | 3 primary references | 2026 |
| Ridge Living. City Access. Modern Medicine. A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Internal Medicine & Prevention) The ridge between the rivers. Roxborough residents get the best of both worlds: suburban space with city access, and now, modern virtual primary care. Primary anchor: Sniderman, A. D., et al. (2019). Apolipoprotein B Particles and Cardiovascular Disease: A Narrative Review. JAMA Cardiology, 4(12), 1287-1295. | 3 primary references | 2026 |
| South Philly Grit. Evidence-Based Care. A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Internal Medicine & Prevention) Southwark doesn't do nonsense, and neither do we: straight talk, sound medicine, and a doctor who respects your time. Primary anchor: Whelton, P. K., et al. (2018). 2017 ACC/AHA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults. Hypertension, 71(6), e13-e115. | 3 primary references | 2026 |
| Survodutide: The GLP-1/Glucagon Drug Built for the Liver A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Metabolic Medicine & Bioenergetics) Survodutide is Boehringer Ingelheim's investigational GLP-1/glucagon dual agonist. What the phase 3 SYNCHRONIZE-1 weight result and the phase 2 MASH data show, the glucagon liver angle, the trade-offs, and its investigational status. Primary anchor: le Roux CW, et al. "Survodutide Once Weekly for the Treatment of Adults with Obesity." New England Journal of Medicine. 2026. DOI: 10.1056/NEJMoa2600751. Presented at the American Diabetes Association Scientific Sessions, June 2026. | 3 primary references | 2026 |
| Testosterone for Women A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Endocrinology & Reproductive Health) An evidence-graded guide to testosterone in women from Dr. Ash in Philadelphia. The one use that trials support, and everything that is still unproven. Primary anchor: Davis SR, Baber R, Panay N, et al. (2019). "Global Consensus Position Statement on the Use of Testosterone Therapy for Women." Journal of Clinical Endocrinology and Metabolism, 104(10), 4660-4666. | 3 primary references | 2026 |
| The 2-1-5 Rule: A Physician's Guide to Philadelphia Recycling A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Internal Medicine & Prevention) Stop wish-cycling. Learn the 2-1-5 rule, see where your trash goes (Chester), and protect Philly's air quality. Primary anchor: Pope CA III, Dockery DW. (2006). Health effects of fine particulate air pollution. Journal of the Air & Waste Management Association. | 3 primary references | 2026 |
| The 4 Stages of a Migraine Attack A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) A migraine attack unfolds in four stages: prodrome, aura, headache, and postdrome. Learning the early warning phase is the single most useful skill for treating attacks sooner and cutting them short, from Fishtown Medicine in Philadelphia. Primary anchor: Headache Classification Committee of the International Headache Society (IHS). The International Classification of Headache Disorders, 3rd edition (ICHD-3). Cephalalgia. 2018;38(1):1-211. | 3 primary references | 2026 |
| The Deep Dive A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Internal Medicine & Prevention) Why the 15-minute annual physical fails busy professionals. Fishtown Medicine's 'Deep Dive' moves beyond 'normal' to audit your biology with VO2 Max, ApoB, and... Primary anchor: Mandsager K, et al. Association of Cardiorespiratory Fitness With Long-term Mortality. JAMA Netw Open. 2018. (The definitive VO2 Max study). | 3 primary references | 2026 |
| The Discovery Call: What to Expect A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Health Systems & Clinical Communication) New to Direct Primary Care? Learn what happens during your complimentary discovery call with Dr. Ash and how we determine if we're the right fit for your health goals. Primary anchor: Eskew PM, Klink K. "Direct Primary Care: Practice Distribution and Cost Across the Nation." Journal of the American Board of Family Medicine. 2015. | 3 primary references | 2026 |
| The Membership A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Health Systems & Clinical Communication) All-inclusive, relationship-first primary care for Philadelphia. Primary anchor: Eskew PM, Klink K. Direct Primary Care: Practice Distribution and Cost Across the Nation. J Am Board Fam Med. 2015;28(6):793-801. | 3 primary references | 2026 |
| The Membership FAQ: Clear Answers on Care A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Health Systems & Clinical Communication) Have questions about how Direct Primary Care works? Find answers on insurance, pricing, specialist coordination, and how we differ from concierge medicine. Primary anchor: Eskew PM, Klink K. Direct Primary Care: Practice Distribution and Cost Across the Nation. J Am Board Fam Med. 2015;28(6):793-801. | 3 primary references | 2026 |
| The No-Office Advantage A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Health Systems & Clinical Communication) Why Fishtown Medicine skips the traditional office: a mobile-first, home- visit model that is more responsive and personal than a waiting room. Primary anchor: Stall N, et al. Systematic review of outcomes from home-based primary care programs for homebound older adults. J Am Geriatr Soc. 2014;62(12):2243-2251. | 3 primary references | 2026 |
| The Omega-3 Index: What Your Score Means and How to Raise It A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Diagnostic Imaging & Biomarker Triage) The omega-3 index measures the EPA and DHA in your cells and predicts heart and brain risk better than asking whether you take fish oil. What a good score is, how to reach it, and how Fishtown Medicine uses it in Philadelphia. Primary anchor: Harris WS, Von Schacky C. "The Omega-3 Index: a new risk factor for death from coronary heart disease?" Preventive Medicine. 2004;39(1):212-220. | 3 primary references | 2026 |
| The Philly Throat: Why Your Allergies Are Worse Here A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Internal Medicine & Prevention) Why do new residents get hit so hard? We explain the pollen tsunami, the synergy with air pollution, and how to protect your airways. Primary anchor: D'Amato G, et al. (2015). Climate change, allergies and asthma. Allergy, 70(7), 753-769. | 3 primary references | 2026 |
| The Practice A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Health Systems & Clinical Communication) Meet Dr. Ash, understand our philosophy, and review our practice policies. Primary anchor: Eskew PM, Klink K. "Direct Primary Care: Practice Distribution and Cost Across the Nation." Journal of the American Board of Family Medicine. 2015. | 3 primary references | 2026 |
| The Prenatal Supplement Trap: Why 'Popular' Vitamins Often Fail A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Taking a 'reputable' prenatal vitamin and still deficient? Why all-in-one supplements often fall short, and how Dr. Ash uses a targeted approach. Primary anchor: Hovdenak, N., & Haram, K. (2012). Influence of mineral and vitamin supplements on pregnancy outcome. European Journal of Obstetrics & Gynecology and Reproductive Biology, 164(2), 127-132. | 3 primary references | 2026 |
| Viral Tracker: What's Circulating in Philly A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Internal Medicine & Prevention) What is circulating in Fishtown and Philadelphia right now, including a 3-week URI bug, a GI bug, a summer walking pneumonia wave, plus flu, COVID-19, and norovirus. Updated regularly. Primary anchor: CDC. Weekly Influenza Surveillance Report (FluView). 2025/2026 season data, Region 3. | 3 primary references | 2026 |
| Vitamin C: Immunity and Collagen Support A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Vitamin C is not just for colds. It fuels your adrenal glands and builds collagen. Learn why liposomal Vitamin C is a major upgrade. Primary anchor: Padayatty SJ, et al. Vitamin C as an antioxidant: evaluation of its role in disease prevention. J Am Coll Nutr. 2003. | 3 primary references | 2024 |
| Vitamin K2: Where Calcium Goes Matters A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) How Vitamin K2 protects your arteries while strengthening your bones, and why it is not the same as K1. Primary anchor: Geleijnse JM, et al. Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study. J Nutr. 2004. | 3 primary references | 2025 |
| VO2 Max: The Ultimate Mortality Metric A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Exercise Physiology & Cardiorespiratory Fitness) VO2 Max is the single most powerful predictor of all-cause mortality. Learn how to measure and increase your physiological engine size. Primary anchor: Mandsager K, et al. Association of Cardiorespiratory Fitness With Long-term Mortality Among Adults Undergoing Exercise Treadmill Testing. JAMA Netw Open. 2018;1(6):e183605. The definitive study on fitness and mortality. | 3 primary references | 2026 |
| What Is Craniosacral Therapy? A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) An evidence-graded look at craniosacral therapy: where it comes from, what the research does and does not support, and where gentle body-based work and embodiment fit alongside good medical care. Primary anchor: Guillaud A, Darbois N, Monvoisin R, Pinsault N. "Reliability of Diagnosis and Clinical Efficacy of Cranial Osteopathy: A Systematic Review." PLoS One. 2016;11(12):e0167823. | 3 primary references | 2026 |
| Whey Protein: Muscle Insurance A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Evidence-based guide to whey protein. Why it matters for muscle protein synthesis, healthy aging, and preserving lean mass on GLP-1 medications. Primary anchor: Morton RW, Murphy KT, McKellar SR, et al. A systematic review, meta-analysis and meta-regression of the effect of protein supplementation on resistance training-induced gains in muscle mass and strength in healthy adults. Br J Sports Med. 2018;52(6):376-384. | 3 primary references | 2026 |
| World Cup 2026 Health Guide A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Internal Medicine & Prevention) Visiting Philadelphia for the World Cup? International fans can text Dr. Ash directly for urgent care house calls. Skip the ER, get insurance paperwork that works abroad. Primary anchor: CDC Yellow Book 2024: Health Information for International Travel. Centers for Disease Control and Prevention. | 3 primary references | 2026 |
| You Deliver the Ultimate Member Experience. Who is Caring for Your Team? A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Internal Medicine & Prevention) Data-driven, text-first primary care for Membership Directors, Elite Teaching Pros, and Club Staff in Philadelphia. Primary anchor: Watson AM. Sleep and Athletic Performance. Curr Sports Med Rep. 2017. | 3 primary references | 2024 |
| Zinc: A Gatekeeper for Your Immune System A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) Zinc is not just for colds. Learn how it supports testosterone, thyroid conversion, insulin sensitivity, and gut repair. Primary anchor: Hemila H. Zinc lozenges and the common cold: a meta-analysis comparing zinc acetate and zinc gluconate, and the role of zinc dosage. JRSM Open. 2017. | 3 primary references | 2024 |
| Zone 2 Training: Mitochondrial Base A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Exercise Physiology & Cardiorespiratory Fitness) Why steady-state Zone 2 training is the most potent metabolic drug for longevity. Learn the science of mitochondrial efficiency and fat oxidation. Primary anchor: San Millán I, Brooks GA. Assessment of Metabolic Flexibility by Gas Exchange Measurements. Sports Med. 2018. | 3 primary references | 2024 |
| Amycretin: The Amylin/GLP-1 Drug That Comes as a Pill A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Metabolic Medicine & Bioenergetics) Amycretin (zenagamtide) is Novo Nordisk's investigational amylin/GLP-1 co-agonist, in both an injection and an oral tablet. What the early-phase trials showed, why the pill matters, how it differs from CagriSema, and the early-stage caveats. Primary anchor: Dahl K, Toubro S, Dey S, et al. "Amycretin, a Novel, Unimolecular GLP-1 and Amylin Receptor Agonist Administered Subcutaneously: Results from a Phase 1b/2a Randomised Controlled Study." The Lancet. 2025. DOI: 10.1016/S0140-6736(25)01185-7. | 2 primary references | 2026 |
| Confused by Your Lab Results? A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Clinical Evidence Monographs) You left the appointment unsure what was even tested, what your numbers mean, or what happens next. Here is why that keeps happening, and what care that explains itself looks like in Philadelphia. Primary anchor: Kessels RPC. "Patients' Memory for Medical Information." Journal of the Royal Society of Medicine. 2003;96(5):219-222. | 2 primary references | 2026 |
| Mazdutide: The Oxyntomodulin Drug Approved in China A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Metabolic Medicine & Bioenergetics) Mazdutide is a GLP-1/glucagon dual agonist approved in China for weight and diabetes but not the US. What the GLORY-1 trial showed, its effects on uric acid and lipids, how it compares with survodutide and retatrutide, and its status. Primary anchor: Ji L, Jiang H, Bi Y, et al. "Once-Weekly Mazdutide in Chinese Adults with Obesity or Overweight." New England Journal of Medicine. 2025;392(22):2215-2225. | 2 primary references | 2026 |
| Same-Day Primary Care in Philadelphia A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Internal Medicine & Prevention) How to get same-day primary care in Philadelphia, what counts as 'same-day' across different practice models, and when to use urgent care instead. Primary anchor: Mehrotra, A., Liu, H., Adams, J. L., et al. (2009). Comparing costs and quality of care at retail clinics with that of other medical settings for 3 common illnesses. Annals of Internal Medicine, 151(5), 321-328. | 2 primary references | 2026 |
| Semaglutide (Wegovy) for MASH: What the ESSENCE Trial Showed A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Metabolic Medicine & Bioenergetics) Semaglutide (Wegovy) is FDA-approved for MASH since 2025. What the ESSENCE trial showed for inflammation and fibrosis, how it compares with resmetirom, the weight and heart bonus, and the limits of the evidence. Primary anchor: Sanyal AJ, Newsome PN, et al. "Phase 3 Trial of Semaglutide in Metabolic Dysfunction-Associated Steatohepatitis." New England Journal of Medicine. 2025;392(17):1608-1618. | 2 primary references | 2026 |
| The New Alzheimer's Drugs: What Lecanemab and Donanemab Do A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Geroscience & Healthspan Medicine) Lecanemab (Leqembi) and donanemab (Kisunla) are the first disease-modifying Alzheimer's drugs. How well they work, the ARIA brain-swelling risk, who can take them, the cost, and a balanced look at the modest benefit. Primary anchor: van Dyck CH, Swanson CJ, Aisen P, et al. "Lecanemab in Early Alzheimer's Disease." New England Journal of Medicine. 2023;388(1):9-21. | 2 primary references | 2026 |
| What a Concierge Doctor in Philadelphia Gets You A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Internal Medicine & Prevention) What 'concierge doctor' means in Philadelphia, what it costs, how it differs from direct primary care, and how to tell substance from a rebrand. Primary anchor: Doherty, R. (2015). Assessing the Patient Care Implications of "Concierge" and Other Direct Patient Contracting Practices: A Policy Position Paper From the American College of Physicians. Annals of Internal Medicine, 163(12), 949. | 2 primary references | 2026 |
| CagriSema: The Amylin + GLP-1 Weight-Loss Combo A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Metabolic Medicine & Bioenergetics) CagriSema (cagrilintide + semaglutide) is Novo's investigational amylin-plus- GLP-1 weight-loss combo. What the REDEFINE trials showed, how it compares with tirzepatide, and its regulatory status. Primary anchor: Garvey WT, et al. "Coadministered Cagrilintide and Semaglutide in Adults with Overweight or Obesity." New England Journal of Medicine. 2025;393(7):635-647. | 1 primary reference | 2026 |
| For Employers: A Smarter Health Benefit A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Health Systems & Clinical Communication) A direct primary care benefit for Philadelphia employers. Published actuarial research puts DPC claims costs 12.64% lower and ER visits about 40% lower. What that looks like for a Philly team of 10 or 500. Primary anchor: Busch F, Grzeskowiak D, Huth E. "Direct Primary Care: Evaluating a New Model of Delivery and Financing." Society of Actuaries, commissioned research conducted by Milliman. May 2020. Source of the 12.64% risk-adjusted claims reduction, the approximately 40% reduction in emergency room visits, the 53.6% reduction in emergency room claims cost, and the 25.54% reduction in hospital admissions. | 1 primary reference | 2026 |
| Resmetirom (Rezdiffra): The First MASH Drug A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Metabolic Medicine & Bioenergetics) Resmetirom (Rezdiffra) is the first FDA-approved drug for MASH (fatty liver with fibrosis). How the THR-beta agonist works, what the MAESTRO-NASH trial showed, who it is for, the lipid bonus, and the accelerated-approval caveat. Primary anchor: Harrison SA, Bedossa P, Guy CD, et al. "A Phase 3, Randomized, Controlled Trial of Resmetirom in NASH with Liver Fibrosis." New England Journal of Medicine. 2024;390(6):497-509. | 1 primary reference | 2026 |
| Semaglutide (Ozempic) for Kidney Disease: What FLOW Showed A. Vijayakumar, MD, MS · Fishtown Medicine Clinical Monographs (Metabolic Medicine & Bioenergetics) The FLOW trial showed semaglutide (Ozempic) cuts kidney-failure and related risk by 24% in diabetic kidney disease, earning an FDA kidney indication in 2025. How it works, how it fits with SGLT2 inhibitors and finerenone, and the limits. Primary anchor: Perkovic V, Tuttle KR, Rossing P, et al. "Effects of Semaglutide on Chronic Kidney Disease in Patients with Type 2 Diabetes." New England Journal of Medicine. 2024;391(2):109-121. | 1 primary reference | 2026 |
Bibliographic & Highwire Press Metadata Standard
Every clinical monograph in the Fishtown Medicine library is published open-access without paywalls or registration gates. Pages emit Highwire Press academic meta tags (citation_title, citation_author, citation_publication_date, and citation_fulltext_html_url) alongside Schema.org MedicalWebPage and ScholarlyArticle structured data for Google Scholar and institutional citation crawlers.
Academic, Clinical & Peer Collaboration Contact
For research collaboration, point-of-care clinical decision support evaluation, or medical literature review inquiries, contact Dr. Ashvin Vijayakumar directly.